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Using metformin to stall clonal hematopoiesis
Using metformin to stall clonal hematopoiesis
Three translational studies reveal elevated mitochondrial metabolism as a driver of age-related clonal hematopoiesis and s...
A health boost from the arts
A health boost from the arts
As momentum grows to enlist the arts for better health, critics ask whether the practice is getting ahead of the evidence.
Author Correction: Prediction of mental health risk in adolescents
These authors jointly supervised this work: Matthew Engelhard, Jonathan Posner.Department of Biostatistics and Bioinformat...
Addendum: Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase
Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), 1275 York Avenue, New York, 10021, New York, USAE...
Nutrition research must go local
Understanding the health impacts of local, culturally relevant diets will be critical to advancing precision nutrition acr...
Cancer treatment paradigms in the precision medicine era
To fully harness precision medicine and transform cancer care for the better will require a strategic shift to highly pers...
Surgery avoidable with immunotherapy in mismatch repair-deficient tumors
Surgery avoidable with immunotherapy in mismatch repair-deficient tumors
In a phase 2 trial, complete responses to neoadjuvant dostarlimab allowed most patients with early-stage solid tumors to a...
How US politics is undermining global science
In June 2025, the International Society on Thrombosis and Haemostasis (ISTH) will convene its annual congress in Washingto...
Author Correction: Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial
These authors contributed equally: Jahan Rahman, Ran Xu.Lymphoma Service, Department of Medicine, Memorial Sloan Kettering...
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial
Patients with obesity-related heart failure with preserved ejection fraction (HFpEF) display circulatory volume expansion ...
Editorial Expression of Concern: Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
The editors would like to alert the readers that concerns have been raised regarding some of the data presented in the fig...
High-resolution spatial multiomic census of the human placenta
High-resolution spatial multiomic census of the human placenta
The placenta has an essential role in maintaining a successful pregnancy, yet its molecular composition and functions rema...
An organotypic atlas of human vascular cells
The human vascular system, comprising endothelial (EC) and mural cells, covers a vast surface area in the body, providing ...
Limiting babies’ sugar intake protects them against chronic diseases
Limiting babies’ sugar intake protects them against chronic diseases
Post-war rationing in the UK in 1953 facilitated a natural experiment that now reveals that restricting sugar intake in ea...
Spatial multiomic landscape of the human placenta at molecular resolution
Spatial multiomic landscape of the human placenta at molecular resolution
Successful pregnancy relies directly on the placenta’s complex, dynamic, gene-regulatory networks. Disruption of thi...
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTDs), including coron...
Detailed mapping of chromatin accessibility and transcriptome of the healthy breast
Detailed mapping of chromatin accessibility and transcriptome of the healthy breast
We performed single-nucleus chromatin accessibility mapping and RNA sequencing of breast biopsy samples obtained from heal...
Heat-related mortality in Europe during 2023 and the role of adaptation in protecting health
Heat-related mortality in Europe during 2023 and the role of adaptation in protecting health
The year of 2023 was the warmest on record globally and the second warmest in Europe. Here we applied epidemiological mode...
Spillover effects of targeted malaria interventions benefit neighboring areas
Spillover effects of targeted malaria interventions benefit neighboring areas
In a setting of low malaria transmission, preventive interventions that target human and mosquito parasite reservoirs loca...
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Brain aging process is influenced by various lifestyle, environmental and genetic factors, as well as by age-related and o...
DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism
DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism
Cancer-associated venous thromboembolism (VTE) is a major source of oncologic cost, morbidity and mortality. Identifying h...
Every baby deserves access to genetic screening
Genomics-based newborn screening has the potential to revolutionize healthcare, but new solutions are needed to ensure tha...
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson’s disease: a blinded randomized feasibility trial
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson’s disease: a blinded randomized feasibility trial
Deep brain stimulation (DBS) is a widely used therapy for Parkinson’s disease (PD) but lacks dynamic responsiveness ...
Using unlabeled data to enhance fairness of medical AI
Using unlabeled data to enhance fairness of medical AI
AI models for tasks such as pathology and dermatology struggle to generalize to new patient groups or hospitals that they ...
Climate change and health: understanding mechanisms will inform mitigation and prevention strategies
Climate change and health: understanding mechanisms will inform mitigation and prevention strategies
The cellular and molecular mechanisms underlying the health impacts of climate change must be better understood in order t...
Post-election responsibilities for public health in the Democratic Republic of the Congo
Since gaining independence in 1960, the Democratic Republic of the Congo (DRC) has faced a complicated series of challenge...
Microplastics are everywhere — we need to understand how they affect human health
As evidence emerges describing the accumulation of small plastic particles in various organs and tissues of the body, a mu...
Demographic bias in misdiagnosis by computational pathology models
Demographic bias in misdiagnosis by computational pathology models
Despite increasing numbers of regulatory approvals, deep learning-based computational pathology systems often overlook the...
An autoantibody signature predictive for multiple sclerosis
An autoantibody signature predictive for multiple sclerosis
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remain...
Risk-based lung cancer screening performance in a universal healthcare setting
Risk-based lung cancer screening performance in a universal healthcare setting
Globally, lung cancer is the leading cause of cancer death. Previous trials demonstrated that low-dose computed tomography...
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