An autoantibody signature predictive for multiple sclerosis

Reynolds, R. et al. The neuropathological basis of clinical progression in multiple sclerosis. Acta Neuropathol. 122, 155–170 (2011).

Article  PubMed  Google Scholar 

Freedman, M. S. Multiple Sclerosis and Demyelinating Diseases (Lippincott Williams & Wilkins, 2006).

Sospedra, M. & Martin, R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23, 683–747 (2005).

Article  CAS  PubMed  Google Scholar 

Lassmann, H., Brück, W. & Lucchinetti, C. F. The immunopathology of multiple sclerosis: an overview. Brain Pathol. 17, 210–218 (2007).

Article  PubMed  PubMed Central  Google Scholar 

Li, R., Patterson, K. R. & Bar-Or, A. Reassessing B cell contributions in multiple sclerosis. Nat. Immunol. 19, 696–707 (2018).

Article  CAS  PubMed  Google Scholar 

Sabatino, J. J., Pröbstel, A.-K. & Zamvil, S. S. B cells in autoimmune and neurodegenerative central nervous system diseases. Nat. Rev. Neurosci. 20, 728–745 (2019).

Article  CAS  PubMed  Google Scholar 

Walton, C. et al. Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition. Mult. Scler. 26, 1816–1821 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Wallin, M. T. et al. The prevalence of MS in the United States: a population-based estimate using health claims data. Neurology 92, e1029–e1040 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Rovira, A. et al. A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis. Arch. Neurol. 66, 587–592 (2009).

Article  PubMed  Google Scholar 

Lebrun-Frénay, C. et al. Risk factors and time to clinical symptoms of multiple sclerosis among patients with radiologically isolated syndrome. JAMA Netw. Open 4, e2128271 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Högg, T. et al. Mining healthcare data for markers of the multiple sclerosis prodrome. Mult. Scler. Relat. Disord. 25, 232–240 (2018).

Article  PubMed  Google Scholar 

Disanto, G. et al. Prodromal symptoms of multiple sclerosis in primary care. Ann. Neurol. 83, 1162–1173 (2018).

Article  PubMed  Google Scholar 

Hauser, S. L. & Oksenberg, J. R. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 52, 61–76 (2006).

Article  CAS  PubMed  Google Scholar 

Bjornevik, K. et al. Serum neurofilament light chain levels in patients with presymptomatic multiple sclerosis. JAMA Neurol. 77, 58–64 (2020).

Article  PubMed  Google Scholar 

Bjornevik, K. et al. Longitudinal analysis reveals high prevalence of Epstein–Barr virus associated with multiple sclerosis. Science 375, 296–301 (2022).

Article  CAS  PubMed  Google Scholar 

Ning, L. & Wang, B. Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: a systematic review and meta-analysis. PLoS ONE 17, e0274565 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arbuckle, M. R. et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349, 1526–1533 (2003).

Article  CAS  PubMed  Google Scholar 

Primavera, M., Giannini, C. & Chiarelli, F. Prediction and prevention of type 1 diabetes. Front. Endocrinol. (Lausanne) 11, 248 (2020).

Article  PubMed  Google Scholar 

Alpizar-Rodriguez, D. & Finckh, A. Is the prevention of rheumatoid arthritis possible? Clin. Rheumatol. 39, 1383–1389 (2020).

Article  PubMed  Google Scholar 

Hundt, J. E., Hoffmann, M. H., Amber, K. T. & Ludwig, R. J. Editorial: Autoimmune pre-disease. Front. Immunol. 14, 1159396 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Höftberger, R., Lassmann, H., Berger, T. & Reindl, M. Pathogenic autoantibodies in multiple sclerosis—from a simple idea to a complex concept. Nat. Rev. Neurol. 18, 681–688 (2022).

Article  PubMed  Google Scholar 

Kuerten, S. et al. Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients. Proc. Natl Acad. Sci. USA 117, 21512–21518 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McLaughlin, K. A. & Wucherpfennig, K. W. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv. Immunol. 98, 121–149 (2008).

Ramesh, A. et al. A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis. Proc. Natl Acad. Sci. USA 117, 22932–22943 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willis, S. N. et al. Investigating the antigen specificity of multiple sclerosis central nervous system-derived immunoglobulins. Front. Immunol. 6, 600 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Elliott, C. et al. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135, 1819–1833 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Greenfield, A. L. et al. Longitudinally persistent cerebrospinal fluid B-cells can resist treatment in multiple sclerosis. JCI Insight 4, e126599 (2019).

PubMed  PubMed Central  Google Scholar 

Petzold, A. Intrathecal oligoclonal IgG synthesis in multiple sclerosis. J. Neuroimmunol. 262, 1–10 (2013).

Article  CAS  PubMed  Google Scholar 

Wijnands, J. M. A. et al. Prodrome in relapsing-remitting and primary progressive multiple sclerosis. Eur. J. Neurol. 26, 1032–1036 (2019).

Article  CAS  PubMed  Google Scholar 

Tremlett, H. & Marrie, R. A. The multiple sclerosis prodrome: emerging evidence, challenges, and opportunities. Mult. Scler. 27, 6–12 (2021).

Article  PubMed  Google Scholar 

Pavlin, J. A. & Welch, R. A. Ethics, human use, and the Department of Defense Serum Repository. Mil. Med. 180, 49–56 (2015).

Article  PubMed  Google Scholar 

Larman, H. B. et al. Autoantigen discovery with a synthetic human peptidome. Nat. Biotechnol. 29, 535–541 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandel-Brehm, C. et al. Kelch-like protein 11 antibodies in seminoma-associated paraneoplastic encephalitis. N. Engl. J. Med. 381, 47–54 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vazquez, S. E. et al. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. eLife 9, e55053 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandel-Brehm, C. et al. Autoantibodies to perilipin-1 define a subset of acquired generalized lipodystrophy. Diabetes 72, 59–70 (2022). db211172.

Article  PubMed Central  Google Scholar 

Mandel-Brehm, C. et al. ZSCAN1 autoantibodies are associated with pediatric paraneoplastic ROHHAD. Ann. Neurol. 92, 279–291 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larman, H. B. et al. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J. Autoimmun. 43, 1–9 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rasquinha, M. T. et al. PhIP-Seq reveals autoantibodies for ubiquitously expressed antigens in viral myocarditis. Biology 11, 1055 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rasquinha, M. T., Lasrado, N., Larman, B. H. & Reddy, J. PhIP-Seq analysis reveals autoantibodies for novel antigens in the mouse model of Coxsackievirus B3 infection. J. Immunol. 206, 21.19 (2021).

Article  Google Scholar 

Lanz, T. V. et al. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature 603, 321–327 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayoglu, B. et al. Anoctamin 2 identified as an autoimmune target in multiple sclerosis. Proc. Natl Acad. Sci. USA 113, 2188–2193 (2016).

Comments (0)

No login
gif