Saloni D, et al. Data page: life expectancy at birth. In: Life expectancy. 2023. https://ourworldindata.org/grapher/life-expectancy. Accessed 11 Oct 2024.

Rozhok AI, DeGregori J. The evolution of lifespan and age-dependent cancer risk. Trends Cancer. 2016;2:552–60.

Article  PubMed  PubMed Central  Google Scholar 

Gu X, Zheng R, Xia C, Zeng H, Zhang S, Zou X, et al. Interactions between life expectancy and the incidence and mortality rates of cancer in China: a population-based cluster analysis. Cancer Commun (Lond). 2018;38:44.

PubMed  Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Article  PubMed  Google Scholar 

Ellsworth S, Ye X, Grossman SA. Clinical, radiographic, and pathologic findings in patients undergoing reoperation following radiation therapy and temozolomide for newly diagnosed glioblastoma. Am J Clin Oncol. 2017;40:219–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohammed S, Dinesan M, Ajayakumar T. Survival and quality of life analysis in glioblastoma multiforme with adjuvant chemoradiotherapy: a retrospective study. Rep Pract Oncol Radiother. 2022;27:1026–36.

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Zhu H, Oprea TI, Golbraikh A, Tropsha A. QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm Res. 2008;25:1902–14.

Article  CAS  PubMed  Google Scholar 

Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective-a review. Drug Deliv Transl Res. 2013;3:42–62.

Article  CAS  PubMed  Google Scholar 

Pardridge WM. Drug transport across the blood-brain barrier. J Cereb Blood Flow Metab. 2012;32:1959–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hersh AM, Alomari S, Tyler BM. Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology. Int J Mol Sci. 2022;23:4153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathew EN, Berry BC, Yang HW, Carroll RS, Johnson MD. Delivering therapeutics to glioblastoma: overcoming biological constraints. Int J Mol Sci. 2022;23:1711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bregy A, et al. The role of Gliadel wafers in the treatment of high-grade gliomas. Expert Rev Anticancer Ther. 2013;13(12):1453–61.

Article  CAS  PubMed  Google Scholar 

Ashby LS, Smith KA, Stea B. Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review. World J Surg Onc. 2016;14:225. https://doi.org/10.1186/s12957-016-0975-5.

Article  Google Scholar 

Perry J, et al. Gliadel wafers in the treatment of malignant glioma: a systematic review. Curr Oncol. 2007;14(5):189–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barua NU, Gill SS, Love S. Convection-enhanced drug delivery to the brain: therapeutic potential and neuropathological considerations. Brain Pathol. 2014;24(2):117–27.

Article  CAS  PubMed  Google Scholar 

Selvaraj K, Gowthamarajan K, Karri V. Nose to brain transport pathways an overview: potential of nanostructured lipid carriers in nose to brain targeting. Artif Cells Nanomed Biotechnol. 2018;46:2088–95.

CAS  PubMed  Google Scholar 

Pardeshi CV, Belgamwar VS. Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting. Expert Opin Drug Deliv. 2013;10:957–72.

Article  CAS  PubMed  Google Scholar 

Costa CP, Moreira JN, Sousa Lobo JM, Silva AC. Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: a current overview of in vivo studies. Acta Pharm Sin B. 2021;11:925–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kou D, Gao Y, Li C, Zhou D, Lu K, Wang N, et al. Intranasal pathway for nanoparticles to enter the central nervous system. Nano Lett. 2023;23:5381–90.

Article  CAS  PubMed  Google Scholar 

Jin J, Sklar GE, Min Sen OhV, Chuen LS. Factors affecting therapeutic compliance: a review from the patient’s perspective. Ther Clin Risk Manag. 2008;4(1):269–86. https://doi.org/10.2147/tcrm.s1458.

Article  PubMed  PubMed Central  Google Scholar 

Wahajuddin Arora S. Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine. 2012;7:3445–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang SH, Hong YK, Jeun SS, Kim IS, Hong JT, Sung JH, Son BC, Lee SW, Kim MC, Lee KS. Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse. J Neurooncol. 2009;95(1):23–8. https://doi.org/10.1007/s11060-009-9895-3.

Article  CAS  PubMed  Google Scholar 

Choi JH, Lee JE, Kim SH, Kim HL, Jeun SS, Yang SH. Functional survival of rat pituitary gland in hypothermic storage for pituitary transplantation. Pituitary. 2019;22(4):353–61. https://doi.org/10.1007/s11102-019-00959-7.

Article  CAS  PubMed  Google Scholar 

Barreto JA, O’Malley W, Kubeil M, Graham B, Stephan H, Spiccia L. Nanomaterials: applications in cancer imaging and therapy. Adv Mater. 2011;23:H18-40.

CAS  PubMed  Google Scholar 

Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3:16–20.

Article  CAS  PubMed  Google Scholar 

Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov. 2010;9:615–27.

Article  CAS  PubMed  Google Scholar 

Shan X, Gong X, Li J, Wen J, Li Y, Zhang Z. Current approaches of nanomedicines in the market and various stage of clinical translation. Acta Pharm Sin B. 2022;12:3028–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6:688–701.

Article  CAS  PubMed  Google Scholar 

Jena L, McErlean E, McCarthy H. Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme. Drug Deliv Transl Res. 2020;10:304–18.

Article  PubMed  Google Scholar 

Chenthamara D, Subramaniam S, Ramakrishnan SG, Krishnaswamy S, Essa MM, Lin FH, et al. Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res. 2019;23:20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Z, Li M, Dey R, Chen Y. Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol. 2021;14:85.

Article  PubMed  PubMed Central  Google Scholar 

Guo X, Shi C, Wang J, Di S, Zhou S. pH-triggered intracellular release from actively targeting polymer micelles. Biomaterials. 2013;34:4544–54.

Article