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Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice
The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, wh...
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Combined aerobic and strength exercise training on biological ageing in Singaporean breast cancer patients: protocol for the Breast Cancer Exercise Intervention (BREXINT) Pilot Study
Breast cancer (BC) is the most prominent cancer amongst women, but fortunately, early diagnosis and advances in multimodal...
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease
Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the ...
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Studies of longevity rely on baseline life expectancy of reference genotypes measured in standardized conditions. Variatio...
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
Neuroinflammation, triggered by aberrantly activated microglia, is widely recognized as a key contributor to the initiatio...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy
Cerebrovascular dysregulation and postoperative cognitive alterations after carotid endarterectomy
There are controversial data about the effect of carotid endarterectomy regarding postoperative cognitive function. Our ai...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health, epigenetic ageing, and long-term mortality in older Australians
Self-rated health (SRH) is a subjective indicator of overall health based on a single questionnaire item. Previous evidenc...
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma
Chronic subdural hematoma (cSDH) is one of the most prevalent neurosurgical diseases, especially in the elderly. Yet, its ...
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
A loss of primary cilia by a reduction in mTOR signaling correlates with age-related deteriorations in condylar cartilage
Age-related deterioration of condylar cartilage is an etiological factor in temporomandibular joint-osteoarthritis (TMJ-OA...
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia
Traumatic brain injury (TBI) is one of the foremost causes of disability and mortality globally. While the scientific and ...
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words
The extent to which the neural systems underlying semantic processes degrade with advanced age remains unresolved, which m...
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradi...
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
The incidence of aortic valve stenosis (AoS) increases with age, and once diagnosed, symptomatic severe AoS has a yearly m...
Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study
Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study
Cardiovascular endurance and muscular fitness seem to impact specific cognitive components in older females. However, it r...
The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction
The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction
Dietary restriction (DR), the process of decreasing overall food consumption over an extended period of time, has been sho...
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks ...
Correction to: Using non‑invasive behavioral and physiological data to measure biological age in wild baboons
Correction to: Using non‑invasive behavioral and physiological data to measure biological age in wild baboons
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USAChelsea J. Weibel, Mauna R. Dasari, David ...
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain
Age-related cerebromicrovascular changes, including blood-brain barrier (BBB) disruption and microvascular rarefaction, pl...
Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation
Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation
Phylloquinon (PK) and menaquinones (MK) are both naturally occurring compounds belonging to vitamin K group. Present study...
Correction to: Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects
Correction to: Role of Toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects
Correction to: GeroScience (2014) 36:9734The legend for Figure 2 has been corrected a...
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis Universit...
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator as...
Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax
Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax
Emerging evidence from both clinical and preclinical studies underscores the role of aging in potentiating the detrimental...
Correction to: Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults
Correction to: Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults
Cite this articleLópez‑López, S., Abuín‑Porras, V., Berlanga, L.A. et al. Correction to: Functional mobility and physical ...
The association of leukocyte telomere length with exceptional longevity among older women
The association of leukocyte telomere length with exceptional longevity among older women
The association of leukocyte telomere length (LTL) with survival to late life with intact mobility has not been adequately...
Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques
Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques
Increasing age is associated with dysregulated immune function and increased inflammation—patterns that are also obs...
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