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Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells
Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells
Aging is linked to various dysfunctions of the immune system, including the decline of its primary developmental source: t...
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increas...
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (S...
Ageing and dysregulated lung immune responses in fatal COVID-19
Ageing and dysregulated lung immune responses in fatal COVID-19
Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19...
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plastic...
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation
MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged...
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Immunotherapy with checkpoint inhibition (ICI) is increasingly prescribed to older patients with cancer. High age, especia...
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling
Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered ...
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults
Memory responses to the antigens that an individual encounters throughout life may vary with the intensity and duration of...
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway
Natural killer (NK) cells are crucial innate immune cells that provide defense against viruses and tumors. However, aging ...
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses
Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of infl...
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes
Most insects are poikilotherms and ectotherms, so their body temperature is predicated by environmental temperature. With ...
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells
Ageing is associated with an increased risk of lung infection and chronic inflammatory lung disease. Innate immune respons...
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults
Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked increase of SARS-CoV-2 spike-specifi...
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice
Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including anti...
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. ...
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Correction: The interplay between obesity, immunosenescence, and insulin resistance
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). Howe...
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, ...
Impact of NAD+ metabolism on ovarian aging
Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-r...
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remai...
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T...
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adver...
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to...
Toll-like receptor 4 (TLR4): new insight immune and aging
Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous l...
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to th...
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. W...
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease...
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months ...
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