Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence. Trends Cell Biol. 2018;28(6):436–53.
Zhou D, Borsa M, Simon AK. Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells. Aging Cell. 2021;20(2):e13316.
CAS PubMed PubMed Central Google Scholar
Weyand CM, Yang Z, Goronzy J. J. T-cell aging in rheumatoid arthritis. Curr Opin Rheumatol. 2014;26(1):93–100.
CAS PubMed PubMed Central Google Scholar
González-Osuna L, Sierra-Cristancho A, Rojas C, Cafferata EA, Melgar-Rodríguez S, Cárdenas AM, Vernal R. Premature senescence of T-cells favors bone loss during osteolytic diseases. A new concern in the osteoimmunology arena. Aging Dis. 2021;12(5):1150–61.
PubMed PubMed Central Google Scholar
Vallejo AN, Weyand CM, Goronzy JJ. T-cell senescence: A culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med. 2024;10(3):119–24.
Birch J, Gil J. Senescence and the SASP: many therapeutic avenues. Genes Dev. 2020;34(23–24):1565–76.
CAS PubMed PubMed Central Google Scholar
Xu Y, Li N, Xiang R, Sun P. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci. 2014;39(6):268–76.
CAS PubMed PubMed Central Google Scholar
Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X. Transcriptional factor HBP1 targets P16INK4A, upregulating its expression and consequently is involved in Ras-induced premature senescence. Oncogene. 2010;29(36):5083–94.
Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong M-Q, Frangou CG, Yates III, Wright JR, P. E., Han. J. PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007;128(2):295–308.
Webber JL, Tooze SA. Coordinated regulation of autophagy by p38a MAPK through mAtg9 and p38IP. EMBO J. 2010;29(1):27–40.
Borodkina A, Shatrova A, Abushik P, Nikolsky N, Burova E. Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging. 2014;6(6):481–95.
PubMed PubMed Central Google Scholar
Freund A, Patil CK, Campisi J. p38 MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 2011;30(8):1536–48.
CAS PubMed PubMed Central Google Scholar
Callender LA, Carroll EC, Beal RWJ, Chambers ES, Nourshargh S, Akbar AN, Henson SM. Human CD8 + EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. Aging Cell. 2018;17(1):e12675.
Henson SM, Lanna A, Riddel NE, Franzese O, Macaulay R, Griffiths SJ, Puleston DJ, Watson AS, Simon AK, Tooze SA, Akbar. A. N. p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells. J Clin Invest. 2014;124(9):4004–16.
CAS PubMed PubMed Central Google Scholar
Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Nikolajczyk BS. Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation. Cell Metab. 2020;32(1):44–e556.
CAS PubMed PubMed Central Google Scholar
Chen J-H, Ozanne SE, Hales CN. Methods of cellular senescence induction using oxidative stress. Methods Mol Biol. 2007;371:179–89.
Tai H, Wang Z, Gong H, Han X, Zhou J, Wang X, Wei X, Ding Y, Huang N, Qin J, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZM, Xiang R, Xiao H. Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence. Autophagy. 2017;13(1):99–113.
Wang Y, Li Y, Li Y, Cui Y, Zhang Y, Shi W, Wang J, Wu X, Liang R, Wang X, Zheng A, Yu Y, Xiong Y. The LncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. Expert Opin Ther Targets. 2023;27(4–5):393–407.
Tsang M, Gantchev J, Ghazawi FM, Litvinov IV. Protocol for adhesion and immunostaining of lymphocytes and other non-adherent cells in culture. Biotechniques. 2017;63(5):230–3.
Hernández-Cáceres MP, Cereceda K, Hernández S, Li Y, Narro C, Rivera P, Silva P, Ávalos Y, Jara C, Burgos P, Toledo-Valenzuela L, Lagos P, Cifuentes Araneda F, Perez-Leighton C, Bertocchi C, Clegg DJ, Criollo A, Tapia-Rojas C, Burgos PV, Morselli E. Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics. Mol Cell Oncol. 2020;7(5):1789418.
PubMed PubMed Central Google Scholar
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021;17:1-382.
Murakawa T, Ito J, Rusu MC, Taneike M, Omiya S, Moncayo-Arlandi J, Nakanishi C, Sugihara R, Nishida H, Mine K, Fleck R, Zhang M, Nishida K, Shah AM, Yamaguchi O, Sakata Y, Otsu K. AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection. Cell Rep. 2024;43(12):115001.
CAS PubMed PubMed Central Google Scholar
Ravanan P, Srikumar IF, Talwar P. Autophagy: the spotlight for cellular stress responses. Life Sci. 2017;188:53–67.
Korolchuk VI, Miwa S, Carroll B. Zglinicki, T. Mitochondria in cell senescence: is mitophagy the weakest link? EBioMedicine. 2017;21:7–13. von.
PubMed PubMed Central Google Scholar
Park JT, Lee YS, Cho KA, Park SC. Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence. Ageing Res Rev. 2018;47:176–82.
Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, Hwang ES. Senescence-associated β-galactosidase is lysosomal β-galactosidase. Aging Cell. 2006;5(2):187–95.
Pargellis C, Tong L, Churchill L, Cirillo PF, Gilmore T, Graham AG, Grob PM, Hickey ER, Moss N, Pav S, Regan J. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat Struct Biol. 2002;9(4):268–72.
Singh B, Bhaskar S. Methods for detection of autophagy in mammalian cells. Methods Mol Biol. 2019;2045:245–58.
Zhen A, Mu W, Rezek V, Martin H, Carrillo MA, Tomer S, Hamid P. Autophagy inducer Rapamycin treatment reduces IFN-I–mediated inflammation and improves anti–HIV-1 T cell response in vivo. JCI Insight. 2022;7(22):e159136.
PubMed PubMed Central Google Scholar
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly‐Y M, Rodriguez‐Cuenca S, Passos JF. Mitochondria are required for pro‐ageing features of the senescent phenotype. EMBO J. 2016;35(7):724–42.
CAS PubMed PubMed Central Google Scholar
González-Osuna L, Sierra-Cristancho A, Cafferata EA, Melgar-Rodríguez S, Rojas C, Carvajal P, Cortez C, Vernal R, Senescent. CD4 + CD28- T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption during periodontitis. Int J Mol Sci. 2022;23(5):2543.
PubMed PubMed Central Google Scholar
Alvarez C, Monasterio G, Cavalla F, Córdova LA, Hernández M, Heymann D, Garlet GP, Sorsa T, Pärnänen P, Lee HM, Golub LM, Vernal R, Kantarci A. Osteoimmunology of oral and maxillofacial diseases: translational applications based on biological mechanisms. Front Immunol. 2019;10:1664.
CAS PubMed PubMed Central Google Scholar
Kim K-W, Kim H-R, Kim B-M, Cho M-L, Lee S-H. Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis. Am J Pathol. 2015;185(11):3011–24.
Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006;203(12):2673–82.
CAS PubMed PubMed Central Google Scholar
Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic Th17 cells. Nat Immunol. 2012;13(10):991–9.
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