McGeer PL, McGeer EG. Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci. 2004;1035:104–16.
Article CAS PubMed Google Scholar
Amor S, Peferoen LA, Vogel DY, Breur M, van der Valk P, Baker D, et al. Inflammation in neurodegenerative diseases–an update. Immunology. 2014;142(2):151–66.
Article CAS PubMed PubMed Central Google Scholar
Gustafson CE, Kim C, Weyand CM, Goronzy JJ. Influence of immune aging on vaccine responses. J Allergy Clin Immunol. 2020;145(5):1309–21.
Article CAS PubMed PubMed Central Google Scholar
Foster AD, Sivarapatna A, Gress RE. The aging immune system and its relationship with cancer. Aging Health. 2011;7(5):707–18.
Article CAS PubMed PubMed Central Google Scholar
Goronzy JJ, Weyand CM. Immune aging and autoimmunity. Cell Mol Life Sci. 2012;69(10):1615–23.
Article CAS PubMed PubMed Central Google Scholar
Geiger H, de Haan G, Florian MC. The ageing Haematopoietic stem cell compartment. Nat Rev Immunol. 2013;13(5):376–89.
Article CAS PubMed Google Scholar
Lang PO, Govind S, Aspinall R. Reversing T cell immunosenescence: why, who, and how. Age (Dordr). 2013;35(3):609–20.
Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013;123(3):958–65.
Article CAS PubMed PubMed Central Google Scholar
Weyand CM, Goronzy JJ. Aging of the immune system. Mechanisms and therapeutic targets. Ann Am Thorac Soc. 2016;13(Suppl 5):S422–8.
Article PubMed PubMed Central Google Scholar
Borgoni S, Kudryashova KS, Burka K, de Magalhaes JP. Targeting immune dysfunction in aging. Ageing Res Rev. 2021;70:101410.
Article CAS PubMed Google Scholar
Li G, Yu M, Lee W-W, Tsang M, Krishnan E, Weyand CM, et al. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med. 2012;18(10):1518–24.
Article CAS PubMed PubMed Central Google Scholar
Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, et al. SIRT3 reverses aging-associated degeneration. Cell Rep. 2013;3(2):319–27.
Article CAS PubMed PubMed Central Google Scholar
Rozman P. The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span. Geroscience. 2018;40(3):221–42.
Article CAS PubMed PubMed Central Google Scholar
Rozman P. How could we slow or reverse the human aging process and extend the healthy life span with heterochronous autologous hematopoietic stem cell transplantation. Rejuvenation Res. 2020;23(2):159–70.
Kovina MV, Karnaukhov AV, Krasheninnikov ME, Kovin AL, Gazheev ST, Sergievich LA, et al. Extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old mice. Front Genet. 2019;10:310.
Article PubMed PubMed Central Google Scholar
Jazbec K, Jež M, Švajger U, Smrekar B, Miceska S, Rajčevič U, et al. The influence of heterochronic non-myeloablative bone marrow transplantation on the immune system, frailty, general health, and longevity of aged murine recipients. Biomolecules. 2022;12(4):595.
Article CAS PubMed PubMed Central Google Scholar
Jazbec K, Jez M, Smrekar B, Miceska S, Rozman JZ, Svajger U, et al. Chimerism and gene therapy - Lessons learned from non-conditioned murine bone marrow transplantation models. Eur J Haematol. 2018;100(4):372–82.
Article CAS PubMed Google Scholar
Justin M, Randl ER, Kononenko V, Hocevar M, Drobne D, Rozman P. Morphological characteristics of young and old murine hematopoietic stem cell niches, as modeled in vitro. Scanning. 2023;2023:5541050.
Article PubMed PubMed Central Google Scholar
Lountzi D, Henzel K, Jazbec K, Bano D, Krauss S, Rozman P, et al. Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice. Mech Ageing Dev. 2020;191:111327.
Article CAS PubMed Google Scholar
Jazbec K, Jez M, Svajger U, Smrekar B, Miceska S, Rajcevic U et al. The influence of heterochronic Non-Myeloablative bone marrow transplantation on the immune system, frailty, general health, and longevity of aged murine recipients. Biomolecules. 2022;12(4).
Pinho S, Frenette PS. Haematopoietic stem cell activity and interactions with the niche. Nat Rev Mol Cell Biol. 2019;20(5):303–20.
Article CAS PubMed PubMed Central Google Scholar
Cain TL, Derecka M, McKinney-Freeman S. The role of the Haematopoietic stem cell niche in development and ageing. Nat Rev Mol Cell Biol. 2025;26(1):32–50.
Article CAS PubMed Google Scholar
Bacharach T, Kaushansky N, Shlush LI. Age-related micro-environmental changes as drivers of clonal hematopoiesis. Curr Opin Hematol. 2024;31(2):53–7.
Article CAS PubMed Google Scholar
Zioni N, Bercovich AA, Chapal-Ilani N, Bacharach T, Rappoport N, Solomon A, et al. Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis. Nat Commun. 2023;14(1):2070.
Article CAS PubMed PubMed Central Google Scholar
Aaron N, Costa S, Rosen CJ, Qiang L. The implications of bone marrow adipose tissue on inflammaging. Front Endocrinol (Lausanne). 2022;13:853765.
Maryanovich M, Zahalka AH, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med. 2018;24(6):782–91.
Article CAS PubMed PubMed Central Google Scholar
Frisch BJ, Hoffman CM, Latchney SE, LaMere MW, Myers J, Ashton J et al. Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B. JCI Insight. 2019;5.
Kusumbe AP, Ramasamy SK, Itkin T, Mae MA, Langen UH, Betsholtz C, et al. Age-dependent modulation of vascular niches for Haematopoietic stem cells. Nature. 2016;532(7599):380–4.
Article CAS PubMed PubMed Central Google Scholar
Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012;119(11):2500–9.
Article CAS PubMed PubMed Central Google Scholar
Guidi N, Sacma M, Standker L, Soller K, Marka G, Eiwen K, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017;36(7):840–53.
Article CAS PubMed PubMed Central Google Scholar
Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, et al. Adipocyte accumulation in the bone marrow during obesity and aging impairs stem Cell-Based hematopoietic and bone regeneration. Cell Stem Cell. 2017;20(6):771–84. e6.
Comments (0)