Battineni G, Sagaro GG, Chintalapudi N, Amenta F, Tomassoni D, Tayebati SK. Impact of obesity-induced inflammation on cardiovascular diseases (CVD). Int J Mol Sci. 2021;22(9): 4798.
Article CAS PubMed PubMed Central Google Scholar
Palavra F, Almeida L, Ambrósio AF, Reis F. Obesity and brain inflammation: a focus on multiple sclerosis. Obes Rev. 2016;17(3):211–24.
Article CAS PubMed Google Scholar
Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010;2010:289645.
Article PubMed PubMed Central Google Scholar
Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022;55(1):31–55.
Article CAS PubMed PubMed Central Google Scholar
Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YJY. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB J. 2018;32(5):2866–77.
Article PubMed PubMed Central Google Scholar
Lee ML, Matsunaga H, Sugiura Y, Hayasaka T, Yamamoto I, Ishimoto T, et al. Prostaglandin in the ventromedial hypothalamus regulates peripheral glucose metabolism. Nat Commun. 2021;12(1):2330.
Article CAS PubMed PubMed Central Google Scholar
Lam TKT, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med. 2005;11(3):320–7.
Article CAS PubMed Google Scholar
Palkovits M. Hypothalamic regulation of food intake. Ideggyogyaszati Szle. 2003;56(9–10):288–302.
Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav. 2001;74(4–5):683–701.
Article CAS PubMed Google Scholar
Kim K, Choe HK. Role of hypothalamus in aging and its underlying cellular mechanisms. Mech Ageing Dev. 2019;177:74–9.
Article CAS PubMed Google Scholar
Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, et al. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol. 2008;28(11):1982–8.
Article CAS PubMed PubMed Central Google Scholar
Mori MA, Liu M, Bezy O, Almind K, Shapiro H, Kasif S, et al. A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease. Diabetes. 2010;59(11):2960–71.
Article CAS PubMed PubMed Central Google Scholar
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–808.
Article CAS PubMed PubMed Central Google Scholar
Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012;122(1):153–62.
Article CAS PubMed Google Scholar
Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014;9(6):2124–38.
Article CAS PubMed PubMed Central Google Scholar
Baufeld C, Osterloh A, Prokop S, Miller KR, Heppner FL. High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathol (Berl). 2016;132(3):361–75.
Article CAS PubMed Google Scholar
Sone H, Kagawa Y. Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetologia. 2005;48(1):58–67.
Article CAS PubMed Google Scholar
Pini M, Czibik G, Sawaki D, Mezdari Z, Braud L, Delmont T, et al. Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure. Aging Cell. 2021;20(8):e13421.
Article CAS PubMed PubMed Central Google Scholar
Li Y, Li X, Xue Q, Wang J, Tan J. High-fat diet and dyslipidemia synergistically contribute to T cell senescence in gut associated lymphoid tissue. Exp Gerontol. 2021;151:111404.
Article CAS PubMed Google Scholar
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, et al. Obesity-induced cellular senescence drives anxiety and impairs neurogenesis. Cell Metab. 2019;29(5):1061-1077.e8.
Article CAS PubMed PubMed Central Google Scholar
di d’Adda F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003;426(6963):194–8.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol. 2010;6:347.
Article PubMed PubMed Central Google Scholar
Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;2:4172.
Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct Target Ther. 2023;8(1):1–29. Available from: https://www.nature.com/articles/s41392-023-01502-8. Cited 2024 Sep 11.
Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010;16(5):238–46. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879478/. Cited 2024 Sep 11.
Article CAS PubMed PubMed Central Google Scholar
Grepper D, Tabasso C, Aguettaz AKF, Martinotti A, Ebrahimi A, Lagarrigue S, et al. Methodological advancements in organ-specific ectopic lipid quantitative characterization: effects of high fat diet on muscle and liver intracellular lipids. Mol Metab. 2023;68:101669. Available from: https://www.sciencedirect.com/science/article/pii/S2212877823000030. Cited 2024 Oct 1.
Article CAS PubMed PubMed Central Google Scholar
Wiley CD, Campisi J. From ancient pathways to aging cells-connecting metabolism and cellular senescence. Cell Metab. 2016;23(6):1013–21.
Article CAS PubMed PubMed Central Google Scholar
Hewitt G, Jurk D, Marques FDM, Correia-Melo C, Hardy T, Gackowska A, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun. 2012;3: 708.
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995;92(20):9363–7.
Article CAS PubMed PubMed Central Google Scholar
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997;88(5):593–602.
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