Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer

Harris RA, Tindale L, Cumming RC. Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease. Biogerontology. 2014;15(6):559–77.

Article  CAS  PubMed  Google Scholar 

Baechle JJ, Chen N, Makhijani P, Winer S, Furman D, Winer DA. Chronic inflammation and the hallmarks of aging. Mol Metab. 2023;74:101755.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Liang Q, Ren Y, Guo C, Ge X, Wang L, et al. Immunosenescence: molecular mechanisms and diseases. Signal Transduct Target Ther. 2023;8(1):200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niccoli T, Partridge L. Ageing as a risk factor for disease. Curr Biol. 2012;22(17):R741–52.

Article  CAS  PubMed  Google Scholar 

Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4–9.

Article  PubMed  Google Scholar 

Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, et al. 2022 update on prostate cancer epidemiology and risk factors-a systematic review. Eur Urol. 2023;84(2):191–206.

Article  PubMed  Google Scholar 

Sadighi AA. Aging and the immune system: an overview. J Immunol Methods. 2018;463:21–6.

Article  Google Scholar 

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W, et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022;7(1):391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dubeau CE. The aging lower urinary tract. J Urol. 2006;175(3 Pt 2):S11–5.

PubMed  Google Scholar 

Pfisterer MH, Griffiths DJ, Schaefer W, Resnick NM. The effect of age on lower urinary tract function: a study in women. J Am Geriatr Soc. 2006;54(3):405–12.

Article  PubMed  Google Scholar 

Coelho A, Antunes-Lopes T, Gillespie J, Cruz F. Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: an immunohistochemical study. Neurourol Urodyn. 2017;36(8):1972–80.

Article  CAS  PubMed  Google Scholar 

Zvarova K, Zvara P. Urinary bladder function in conscious rat pups: a developmental study. Am J Physiol Renal Physiol. 2012;302(12):F1563–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aizawa N, Homma Y, Igawa Y. Characteristics of lower urinary tract dysfunction and bladder afferent nerve properties in type 2 diabetic goto-kakizaki rats. J Urol. 2013;189(4):1580–7.

Article  PubMed  Google Scholar 

Shi B, Wu Y, Chen H, Ding J, Qi J. Understanding of mouse and human bladder at single-cell resolution: integrated analysis of trajectory and cell-cell interactive networks based on multiple scRNA-seq datasets. Cell Prolif. 2022;55(1):e13170.

Article  CAS  PubMed  Google Scholar 

Rodhe N, Lofgren S, Strindhall J, Matussek A, Molstad S. Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria. Scand J Prim Health Care. 2009;27(2):74–9.

Article  PubMed  PubMed Central  Google Scholar 

Gracely A, Cameron AP. Managing interstitial cystitis/bladder pain syndrome in older adults. Drugs Aging. 2021;38(1):1–16.

Article  PubMed  Google Scholar 

Detweiler K, Mayers D, Fletcher SG. Bacteruria and Urinary Tract Infections in the Elderly. Urol Clin North Am. 2015;42(4):561–8.

Article  PubMed  Google Scholar 

Su F, Zhang W, Meng L, Zhang W, Liu X, Liu X, et al. Multimodal single-cell analyses outline the immune microenvironment and therapeutic effectors of interstitial cystitis/bladder pain syndrome. Adv Sci (Weinh). 2022;9(18):e2106063.

Article  PubMed  Google Scholar 

Scott MM, Liang SY. Infections in older adults. Emerg Med Clin North Am. 2021;39(2):379–94.

Article  PubMed  Google Scholar 

Martin A, Woolbright BL, Umar S, Ingersoll MA, Taylor JR. Bladder cancer, inflammageing and microbiomes. Nat Rev Urol. 2022;19(8):495–509.

Article  PubMed  Google Scholar 

Babjuk M. Bladder cancer in the elderly. Eur Urol. 2018;73(1):51–2.

Article  PubMed  Google Scholar 

Taylor JR, Kuchel GA. Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction. Nat Clin Pract Urol. 2009;6(3):135–44.

PubMed  PubMed Central  Google Scholar 

Tempo J, Yiu TW, Ischia J, Bolton D, O’Callaghan M. Global changes in bladder cancer mortality in the elderly. Cancer Epidemiol. 2023;82:102294.

Article  PubMed  Google Scholar 

Salem A, Alotaibi M, Mroueh R, Basheer HA, Afarinkia K. CCR7 as a therapeutic target in cancer. Biochim Biophys Acta Rev Cancer. 2021;1875(1):188499.

Article  CAS  PubMed  Google Scholar 

Korbecki J, Grochans S, Gutowska I, Barczak K, Baranowska-Bosiacka I. CC Chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. Int J Mol Sci. 2020;21(20):7619.

Bottazzi B, Riboli E, Mantovani A. Aging, inflammation and cancer. Semin Immunol. 2018;40:74–82.

Article  CAS  PubMed  Google Scholar 

Uyar B, Palmer D, Kowald A, Murua EH, Barrantes I, Moller S, et al. Single-cell analyses of aging, inflammation and senescence. Ageing Res Rev. 2020;64:101156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Simon M, Seluanov A, Gorbunova V. DNA damage and repair in age-related inflammation. Nat Rev Immunol. 2023;23(2):75–89.

Article  CAS  PubMed  Google Scholar 

Lopez-Otin C, Pietrocola F, Roiz-Valle D, Galluzzi L, Kroemer G. Meta-hallmarks of aging and cancer. Cell Metab. 2023;35(1):12–35.

Article  CAS  PubMed  Google Scholar 

Taniguchi K, Karin M. NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309–24.

Article  CAS  PubMed  Google Scholar 

Muller L, Di Benedetto S, Pawelec G. The immune system and its dysregulation with aging. Subcell Biochem. 2019;91:21–43.

Article  PubMed  Google Scholar 

Giannoula Y, Kroemer G, Pietrocola F. Cellular senescence and the host immune system in aging and age-related disorders. Biomed J. 2023;46(3):100581.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Z, Li X, Liu D, Li Z. A novel signature of aging-related genes associated with lymphatic metastasis for survival prediction in patients with bladder cancer. Front Oncol. 2023;13:1140891.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ligon MM, Joshi CS, Fashemi BE, Salazar AM, Mysorekar IU. Effects of aging on urinary tract epithelial homeostasis and immunity. Dev Biol. 2023;493:29–39.

Article  CAS  PubMed  Google Scholar 

Silva R, Sousa DA, Lopes FA, Silva-Ramos M, Verdelho A. Age-related white matter hyperintensities and overactive bladder: a systematic review. Neurourol Urodyn. 2023;42(5):1088–100.

Article  PubMed  Google Scholar 

Nishii H. A review of aging and the lower urinary tract: the future of urology. Int Neurourol J. 2021;25(4):273–84.

Article  PubMed  PubMed Central  Google Scholar 

Ineichen GB, Burkhard FC. Metabolic syndrome and male lower urinary tract symptoms. Panminerva Med. 2022;64(3):329–36.

Article  PubMed  Google Scholar 

Chen LC, Kuo HC. Pathophysiology of refractory overactive bladder. Low Urin Tract Symptoms. 2019;11(4):177–81.

Article  PubMed  Google Scholar 

Xu Z, Elrashidy RA, Li B, Liu G. Oxidative stress: a putative link between lower urinary tract symptoms and aging and major chronic diseases. Front Med (Lausanne). 2022;9:812967.

Article  PubMed  Google Scholar 

Hamade A, Li D, Tyryshkin K, Xu M, Conseil G, Yolmo P, et al. Sex differences in the aging murine urinary bladder and influence on the tumor immune microenvironment of a carcinogen-induced model of bladder cancer. Biol Sex Differ. 2022;13(1):19.

Article  CAS  PubMed  PubMed Central 

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