Jay GD, Waller KA. The biology of lubricin: near frictionless joint motion. Matrix Biol. 2014;39:17–24.

Article  CAS  PubMed  Google Scholar 

Rhee DK, et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005;115(3):622–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alquraini A, et al. The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid. Arthritis Res Ther. 2015;17:353.

Article  PubMed  PubMed Central  Google Scholar 

Iqbal SM, et al. Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro. Sci Rep. 2016;6:18910.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menon NG, et al. Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation. Exp Eye Res. 2021;208:108628.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park DSJ, et al. Human pericardial proteoglycan 4 (lubricin): Implications for postcardiotomy intrathoracic adhesion formation. J Thorac Cardiovasc Surg. 2018;156(4):1598-1608 e1.

Article  PubMed  Google Scholar 

Qadri M, et al. Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration. Arthritis Res Ther. 2021;23(1):241.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt TA, et al. Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface. JAMA Ophthalmol. 2013;131(6):766–76.

Article  CAS  PubMed  Google Scholar 

Das N, et al. Proteomics Analysis of Tears and Saliva From Sjogren’s Syndrome Patients. Front Pharmacol. 2021;12:787193.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toledo AG, et al. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis. Nat Commun. 2019;10(1):4656.

Article  PubMed  PubMed Central  Google Scholar 

Ekinci RMK, et al. Serum lubricin levels in patients with juvenile idiopathic arthritis. Reumatologia. 2021;59(6):373–7.

Article  PubMed  PubMed Central  Google Scholar 

Lee KY, et al. Proteoglycan 4 is a diagnostic biomarker for COPD. Int J Chron Obstruct Pulmon Dis. 2015;10:1999–2007.

CAS  PubMed  PubMed Central  Google Scholar 

Peters B, et al. Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. Pediatr Rheumatol Online J. 2016;14(1):32.

Article  PubMed  PubMed Central  Google Scholar 

Yilmaz S, et al. Genotype-phenotype investigation of 35 patients from 11 unrelated families with camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome. Mol Genet Genomic Med. 2018;6(2):230–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murphy JM, Vanderhave KL, Urquhart AG. Total hip arthroplasty in adolescents with severe hip arthropathy and dysplasia associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome. J Arthroplasty. 2012;27(8):1581 e5-8.

Article  PubMed  Google Scholar 

Boston-Children's-Hospital. Camptodactyly Arthropathy Coxa Vara Pericarditis. 2024 [cited 2024 Dec 20, 2024]; Available from: https://www.childrenshospital.org/research/centers/center-study-genetic-skeletal-disorders-research/research-focus-areas/camptodactyly-arthropathy-coxa-vara-pericarditis

Chen PJ, et al. Age-related changes in the cartilage of the temporomandibular joint. Geroscience. 2020;42(3):995–1004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruan MZ, et al. Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med. 2013;5(176):176ra34.

Article  PubMed  PubMed Central  Google Scholar 

Novince CM, et al. Impact of proteoglycan-4 and parathyroid hormone on articular cartilage. J Orthop Res. 2013;31(2):183–90.

Article  CAS  PubMed  Google Scholar 

Novince CM, et al. Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. Am J Pathol. 2011;179(5):2431–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Novince CM, et al. Proteoglycan 4: a dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism. J Bone Miner Res. 2012;27(1):11–25.

Article  CAS  PubMed  Google Scholar 

Abubacker S, et al. Absence of Proteoglycan 4 (Prg4) Leads to Increased Subchondral Bone Porosity Which Can Be Mitigated Through Intra-Articular Injection of PRG4. J Orthop Res. 2019;37(10):2077–88.

Article  CAS  PubMed  Google Scholar 

Tanguay AP, et al. PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis. J Orthop Res. 2024;42(6):1231–43.

Article  CAS  PubMed  Google Scholar 

Hill A, et al. Lubricin restoration in a mouse model of congenital deficiency. Arthritis Rheumatol. 2015;67(11):3070–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regmi SC, et al. Degradation of proteoglycan 4/lubricin by cathepsin S: Potential mechanism for diminished ocular surface lubrication in Sjogren’s syndrome. Exp Eye Res. 2017;161:1–9.

Article  CAS  PubMed  Google Scholar 

Bouxsein ML, et al. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010;25(7):1468–86.

Article  PubMed  Google Scholar 

When are mice considered old? The Jackson Laboratory Blog Post. 2017. Accessed via https://www.jax.org/news-and-insights/jax-blog/2017/november/when-are-mice-considered-old

McDaniel JS, et al. Transcriptional regulation of proteoglycan 4 by 17beta-estradiol in immortalized baboon temporomandibular joint disc cells. Eur J Oral Sci. 2014;122(2):100–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villa A, et al. Estrogen accelerates the resolution of inflammation in macrophagic cells. Sci Rep. 2015;5:15224.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin-Millan M, Castaneda S. Estrogens, osteoarthritis and inflammation. Joint Bone Spine. 2013;80(4):368–73.

Article  CAS  PubMed  Google Scholar 

Syed FA, et al. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res. 2010;25(11):2438–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Norling LV, Cooper D. Being old and female is an inflammatory combination. J Leukoc Biol. 2023;114(4):299–300.

Article  PubMed  Google Scholar 

Hopkin SJ, et al. Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner. J Leukoc Biol. 2023;114(4):301–14.