Associations of physical frailty and polygenic score with incident heart failure in cardiovascular patients: unraveling the mediating role of inflammation

Breathett K, Lewsey S, Brownell NK, Enright K, Evangelista LS, Ibrahim NE, et al. Implementation science to achieve equity in heart failure care: a scientific statement from the American Heart Association. Circulation. 2024;149(19):e1143–63.

Article  PubMed  Google Scholar 

Roth GA, Dorsey H, Decleene N, Razo C, Stark B, Johnson C, et al. The global burden of heart failure: a systematic analysis for the Global Burden of Disease Study 2021. European Heart Journal. 2023;44(Supplement_2).

Bayes-Genis A, Bozkurt B. Pre-heart failure, heart stress, and subclinical heart failure: bridging heart health and heart failure. JACC Heart Fail. 2024;12(6):1115–8.

Article  CAS  PubMed  Google Scholar 

Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age Ageing. 2020;49(5):758–63.

Article  PubMed  Google Scholar 

Crea F. The Atlas of cardiovascular disease in Europe and a focus on frailty and cardiovascular risk. Eur Heart J. 2022;43(8):703–5.

Article  PubMed  Google Scholar 

He D, Wang Z, Li J, Yu K, He Y, He X, et al. Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. 2024;45(12):1058–68.

Article  PubMed  Google Scholar 

Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895–1032.

PubMed  Google Scholar 

Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017;16(3):444–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marcos-Perez D, Sanchez-Flores M, Proietti S, Bonassi S, Costa S, Teixeira JP, et al. Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis. Geroscience. 2020;42(6):1451–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burger PM, Koudstaal S, Mosterd A, Fiolet ATL, Teraa M, van der Meer MG, et al. C-reactive protein and risk of incident heart failure in patients with cardiovascular disease. J Am Coll Cardiol. 2023;82(5):414–26.

Article  CAS  PubMed  Google Scholar 

Adamo L, Rocha-Resende C, Prabhu SD, Mann DL. Reappraising the role of inflammation in heart failure. Nat Rev Cardiol. 2020;17(5):269–85.

Article  PubMed  Google Scholar 

Zhao Y, Ghaedi A, Azami P, Nabipoorashrafi SA, Drissi HB, Dezfouli MA, et al. Inflammatory biomarkers in cardiac syndrome X: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2024;24(1):276.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindgren MP, PirouziFard M, Smith JG, Sundquist J, Sundquist K, Zoller B. A Swedish nationwide adoption study of the heritability of heart failure. JAMA Cardiol. 2018;3(8):703–10.

Article  PubMed  PubMed Central  Google Scholar 

Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, et al. Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure. Nat Commun. 2022;13(1):6914.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paranjpe I, Tsao NL, De Freitas JK, Judy R, Chaudhary K, Forrest IS, et al. Derivation and validation of genome-wide polygenic score for ischemic heart failure. J Am Heart Assoc. 2021;10(22): e021916.

Article  PubMed  PubMed Central  Google Scholar 

Ma Y, Zhang J, Li D, Tang L, Li Y, Cui F, et al. Genetic susceptibility modifies relationships between air pollutants and stroke risk: a large cohort study. Stroke. 2024;55(1):113–21.

Article  CAS  PubMed  Google Scholar 

Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, et al. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. Lancet Digit Health. 2023;5(6):e350–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Zhou Y, Yu B, Zhang K, Wang B, Tan X, et al. Frailty, genetic predisposition, and incident atrial fibrillation. Eur Heart J. 2024;45(14):1281–3.

Article  PubMed  Google Scholar 

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, et al. Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure. Nat Commun. 2023;14(1):3826.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge T, Chen CY, Ni Y, Feng YA, Smoller JW. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat Commun. 2019;10(1):1776.

Article  PubMed  PubMed Central  Google Scholar 

Barter P, Genest J. HDL cholesterol and ASCVD risk stratification: a debate. Atherosclerosis. 2019;283:7–12.

Article  CAS  PubMed  Google Scholar 

Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380(9841):572–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye Y, Noche RB, Szejko N, Both CP, Acosta JN, Leasure AC, et al. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. Geroscience. 2023;45(4):2511–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, et al. Global Biobank Meta-analysis Initiative: powering genetic discovery across human disease. Cell Genom. 2022;2(10): 100192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knol MJ, VanderWeele TJ. Recommendations for presenting analyses of effect modification and interaction. Int J Epidemiol. 2012;41(2):514–20.

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Shen S, Li Y, Fan J, Xiong S, Xu J, et al. APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparative study of model performance. EBioMedicine. 2022;79: 104007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med. 2017;167(4):268–74.

Article  PubMed  Google Scholar 

Spiers GF, Kunonga TP, Hall A, Beyer F, Boulton E, Parker S, et al. Measuring frailty in younger populations: a rapid review of evidence. BMJ Open. 2021;11(3): e047051.

Article  PubMed  PubMed Central  Google Scholar 

Park S, Kim SG, Lee S, Kim Y, Cho S, Kim K, et al. Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia. J Cachexia Sarcopenia Muscle. 2023;14(2):955–63.

Article  PubMed 

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