Breathett K, Lewsey S, Brownell NK, Enright K, Evangelista LS, Ibrahim NE, et al. Implementation science to achieve equity in heart failure care: a scientific statement from the American Heart Association. Circulation. 2024;149(19):e1143–63.
Roth GA, Dorsey H, Decleene N, Razo C, Stark B, Johnson C, et al. The global burden of heart failure: a systematic analysis for the Global Burden of Disease Study 2021. European Heart Journal. 2023;44(Supplement_2).
Bayes-Genis A, Bozkurt B. Pre-heart failure, heart stress, and subclinical heart failure: bridging heart health and heart failure. JACC Heart Fail. 2024;12(6):1115–8.
Article CAS PubMed Google Scholar
Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age Ageing. 2020;49(5):758–63.
Crea F. The Atlas of cardiovascular disease in Europe and a focus on frailty and cardiovascular risk. Eur Heart J. 2022;43(8):703–5.
He D, Wang Z, Li J, Yu K, He Y, He X, et al. Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. 2024;45(12):1058–68.
Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(18):e895–1032.
Bellumkonda L, Tyrrell D, Hummel SL, Goldstein DR. Pathophysiology of heart failure and frailty: a common inflammatory origin? Aging Cell. 2017;16(3):444–50.
Article CAS PubMed PubMed Central Google Scholar
Marcos-Perez D, Sanchez-Flores M, Proietti S, Bonassi S, Costa S, Teixeira JP, et al. Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis. Geroscience. 2020;42(6):1451–73.
Article CAS PubMed PubMed Central Google Scholar
Burger PM, Koudstaal S, Mosterd A, Fiolet ATL, Teraa M, van der Meer MG, et al. C-reactive protein and risk of incident heart failure in patients with cardiovascular disease. J Am Coll Cardiol. 2023;82(5):414–26.
Article CAS PubMed Google Scholar
Adamo L, Rocha-Resende C, Prabhu SD, Mann DL. Reappraising the role of inflammation in heart failure. Nat Rev Cardiol. 2020;17(5):269–85.
Zhao Y, Ghaedi A, Azami P, Nabipoorashrafi SA, Drissi HB, Dezfouli MA, et al. Inflammatory biomarkers in cardiac syndrome X: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2024;24(1):276.
Article CAS PubMed PubMed Central Google Scholar
Lindgren MP, PirouziFard M, Smith JG, Sundquist J, Sundquist K, Zoller B. A Swedish nationwide adoption study of the heritability of heart failure. JAMA Cardiol. 2018;3(8):703–10.
Article PubMed PubMed Central Google Scholar
Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, et al. Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure. Nat Commun. 2022;13(1):6914.
Article CAS PubMed PubMed Central Google Scholar
Paranjpe I, Tsao NL, De Freitas JK, Judy R, Chaudhary K, Forrest IS, et al. Derivation and validation of genome-wide polygenic score for ischemic heart failure. J Am Heart Assoc. 2021;10(22): e021916.
Article PubMed PubMed Central Google Scholar
Ma Y, Zhang J, Li D, Tang L, Li Y, Cui F, et al. Genetic susceptibility modifies relationships between air pollutants and stroke risk: a large cohort study. Stroke. 2024;55(1):113–21.
Article CAS PubMed Google Scholar
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, et al. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. Lancet Digit Health. 2023;5(6):e350–9.
Article CAS PubMed PubMed Central Google Scholar
Sun Y, Zhou Y, Yu B, Zhang K, Wang B, Tan X, et al. Frailty, genetic predisposition, and incident atrial fibrillation. Eur Heart J. 2024;45(14):1281–3.
Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–9.
Article CAS PubMed PubMed Central Google Scholar
Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, et al. Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure. Nat Commun. 2023;14(1):3826.
Article CAS PubMed PubMed Central Google Scholar
Ge T, Chen CY, Ni Y, Feng YA, Smoller JW. Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nat Commun. 2019;10(1):1776.
Article PubMed PubMed Central Google Scholar
Barter P, Genest J. HDL cholesterol and ASCVD risk stratification: a debate. Atherosclerosis. 2019;283:7–12.
Article CAS PubMed Google Scholar
Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012;380(9841):572–80.
Article CAS PubMed PubMed Central Google Scholar
Ye Y, Noche RB, Szejko N, Both CP, Acosta JN, Leasure AC, et al. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. Geroscience. 2023;45(4):2511–23.
Article CAS PubMed PubMed Central Google Scholar
Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, et al. Global Biobank Meta-analysis Initiative: powering genetic discovery across human disease. Cell Genom. 2022;2(10): 100192.
Article CAS PubMed PubMed Central Google Scholar
Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508–18.
Article CAS PubMed PubMed Central Google Scholar
Knol MJ, VanderWeele TJ. Recommendations for presenting analyses of effect modification and interaction. Int J Epidemiol. 2012;41(2):514–20.
Article PubMed PubMed Central Google Scholar
Chen J, Shen S, Li Y, Fan J, Xiong S, Xu J, et al. APOLLO: An accurate and independently validated prediction model of lower-grade gliomas overall survival and a comparative study of model performance. EBioMedicine. 2022;79: 104007.
Article CAS PubMed PubMed Central Google Scholar
VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med. 2017;167(4):268–74.
Spiers GF, Kunonga TP, Hall A, Beyer F, Boulton E, Parker S, et al. Measuring frailty in younger populations: a rapid review of evidence. BMJ Open. 2021;11(3): e047051.
Article PubMed PubMed Central Google Scholar
Park S, Kim SG, Lee S, Kim Y, Cho S, Kim K, et al. Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia. J Cachexia Sarcopenia Muscle. 2023;14(2):955–63.
Comments (0)