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Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecol...
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights
The burgeoning field of epigenetics holds considerable potential in cancer prevention and management, as it targets mechan...
ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake
Tamoxifen is a critical drug for the treatment of oestrogen receptor (ER)-positive breast cancer (BC), which represents th...
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1
Age-related macular degeneration (AMD) has been well recognized as the first ranked blinding ocular fundus diseases among ...
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer
Breast cancer (BC) is the most frequently diagnosed malignancy among women worldwide, with a high incidence and mortality ...
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway
To investigate the therapeutic potential of Asperosaponin VI (ASA VI) from Clematis chinensis in mitigating osteoarthritis...
Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation
Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation
Osteoporosis (OP) is a systemic skeletal disorder marked by reduced bone density and deterioration of trabecular microstru...
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration
This study investigates how mP6/Rg3 micelles modulate ABCB1 expression to induce ferroptosis in oral cancer stem cells (CS...
FTO-mediated the destabilization of mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization
FTO-mediated the destabilization of mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization
The guanine nucleotide exchange factor RASGRF1 actively acts in a broad range of human cancers, including thyroid cancer (...
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of mG- 3' tiRNA Met
Methyltransferase 1 (METTL1) is currently regarded as a key tRNA m7G writer. Recent studies indicate its potential role in...
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA
Cardiac fibrosis is a critical pathological process following myocardial infarction (MI), contributing to adverse cardiac ...
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1
Sepsis-induced acute kidney injury (SI-AKI) is a severe condition with limited therapeutic options, resulting in poor prog...
Correction to: LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2
Correction to: LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4...
DNMT1 recruits RUNX1 and represses FOXO1 transcription to inhibit anti-inflammatory activity of regulatory T cells and augments sepsis-induced lung injury
DNMT1 recruits RUNX1 and represses FOXO1 transcription to inhibit anti-inflammatory activity of regulatory T cells and augments sepsis-induced lung injury
Sepsis-induced lung injury (ALI) is a critical condition characterized by excessive immune responses and tissue damage. Pr...
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development
Ovarian aging significantly contributes to the decline of the female reproductive system, adversely affecting fertility an...
SP1 and p23 play a crucial role in the circadian target gene induction of activated aryl hydrocarbon receptor in human breast cells
SP1 and p23 play a crucial role in the circadian target gene induction of activated aryl hydrocarbon receptor in human breast cells
The Aryl Hydrocarbon Receptor (AHR) is a crucial mediator of cellular responses upon exposure to environmental pollutants....
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts
Interleukin (IL)-1β and IL-18 are involved in the inflammatory response of wear-induced osteolysis. The production an...
METTL3-driven m⁶A epigenetics in gastric cancer: unveiling oncogenic networks and clinical translation from tumorigenesis to therapy resistance
METTL3-driven m⁶A epigenetics in gastric cancer: unveiling oncogenic networks and clinical translation from tumorigenesis to therapy resistance
Globally, gastric cancer (GC) ranks among the deadliest malignancies due to frequent late-stage detection, metastatic diss...
scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice
scRNA-seq deciphers molecular mechanisms of endocrine disruptor 4-nonylphenol impairing spermatogenesis in mice
4-Nonylphenol (NP) is an environmental endocrine disruptor widely used in consumer products. Previous studies have shown t...
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
Gastrointestinal (GI) cancers are common cancers that are responsible for a large portion of global cancer fatalities. Due...
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver damage, highlighting the limitations of current eme...
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis
The N7-methylguanosine (m7G) modification and circular RNAs (circRNAs) have been shown to play important roles in the deve...
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
Noise-induced hidden hearing loss (HHL) is a newly uncovered form of hearing impairment that causes hidden damage to the c...
Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma
Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma
Tetracaine, a local anesthetic, exhibits potent cytotoxic effects on multiple cancer; however, the precise underlying mech...
ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals
ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signals
Angiotensin-converting enzyme 2 (ACE2), a crucial element of the renin-angiotensin system (RAS), metabolizes angiotensin I...
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
Exogenous gaseous formaldehyde (FA) is recognized as a significant indoor air pollutant due to its chemical reactivity and...
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition
S100A2 activation promotes interstitial fibrosis in kidneys by FoxO1-mediated epithelial-mesenchymal transition
Renal interstitial fibrosis (RIF) is a common feature of chronic kidney diseases (CKD), with epithelial-mesenchymal transi...
EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway
EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway
Esophageal squamous cell carcinoma (ESCC) remains a major clinical challenge due to its poor prognosis and the scarcity ef...
Multifaceted roles of mitochondria in asthma
Multifaceted roles of mitochondria in asthma
Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differ...
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance
The high prevalence and detrimental effects on patient outcomes make gastric cancer (GC) a significant health issue that p...
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