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The food-borne carcinogenic 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) disrupts circadian rhythms and ameliorated by pterostilbene (PSB) in Caenorhabditis elegans
The food-borne carcinogenic 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) disrupts circadian rhythms and ameliorated by pterostilbene (PSB) in Caenorhabditis elegans
The food-borne 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a potential human carcinogen abundant in cooked m...
In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
Some Penicillium strains used in cheese ripening produce emerging mycotoxins, notably roquefortine C (ROQC) and cyclopiazo...
Predictive biomarkers for embryotoxicity: a machine learning approach to mitigating multicollinearity in RNA-Seq
Predictive biomarkers for embryotoxicity: a machine learning approach to mitigating multicollinearity in RNA-Seq
Multicollinearity, characterized by significant co-expression patterns among genes, often occurs in high-throughput expres...
Research advances on CaMKs-mediated neurodevelopmental injury
Research advances on CaMKs-mediated neurodevelopmental injury
Calcium/calmodulin-dependent protein kinases (CaMKs) are important proteins in the calcium signaling cascade response path...
Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols
Elevated blood-ethanol concentration promotes reduction of aliphatic ketones (acetone and ethyl methyl ketone) to secondary alcohols along with slower oxidation to aliphatic diols
Many people convicted for drunken driving suffer from an alcohol use disorder and some traffic offenders consume denatured...
Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants
Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants
New approach methodologies (NAMs) for predicting embryotoxicity and developmental toxicity are urgently needed for generat...
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
Reproductive toxicity is one of the important issues in chemical safety. Traditional laboratory testing methods are costly...
Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis
Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis
Arylacetamide deacetylase (AADAC) catalyzes the hydrolysis of small molecules containing ester and amide bonds. Recently, ...
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism a...
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
Fluoride-induced toxicity (fluorosis) poses a significant health concern globally, affecting millions of individuals. Unde...
Interleukin-9 promotes EMT-mediated PM2.5-induced pulmonary fibrosis by activating the STAT3 pathway
Interleukin-9 promotes EMT-mediated PM2.5-induced pulmonary fibrosis by activating the STAT3 pathway
This study investigated the impact of PM2.5 on promoting EMT in PM2.5-induced pulmonary fibrosis (PF) development and expl...
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Both postmortem toxicological and medical-forensic examinations are very important in the case of analyzing various types ...
Methodological steps forward in toxicological in vitro screening of mineral wools in primary rat alveolar macrophages and normal rat mesothelial NRM2 cells
Methodological steps forward in toxicological in vitro screening of mineral wools in primary rat alveolar macrophages and normal rat mesothelial NRM2 cells
Man-made vitreous fibers (MMVF) comprise diverse materials for thermal and acoustic insulation, including stone wool. Depe...
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
The cGAS–STING pathway plays an essential role in the activation of tumor immune cells. Polycyclic aromatic hydrocar...
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hamper...
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modificati...
Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise
Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise
The side effects and safety of cannabidiol (CBD) products are currently discussed in different contexts. Of all adverse ef...
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Toxic fungal secondary metabolites, referred to as mycotoxins, emerge in moldy food and feed and constitute a potent but o...
Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives
Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives
Plastics are widespread pollutants found in atmospheric, terrestrial and aquatic ecosystems due to their extensive usage a...
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabino...
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
This article analyzes the results from 112 Extended One-Generation Reproductive Toxicity studies. The objective was to det...
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More ...
Simultaneous multi-targeted forensic toxicological screening in biological matrices by MRM-IDA-EPI mode
Simultaneous multi-targeted forensic toxicological screening in biological matrices by MRM-IDA-EPI mode
The toxicologist ascertains drug assumptions in case of paediatric intoxications and death for overdose. The analytical ap...
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used in many industrial applications. Exposure to PFAS i...
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Skeletal fluorosis is a chronic metabolic bone disease caused by long-term excessive fluoride intake. Abnormal differentia...
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multil...
Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis
Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis
Ochratoxin A (OTA), a secondary fungal metabolite known for its nephrotoxic effects, is prevalent in various feeds and foo...
Genotoxicity of selected cannabinoids in human lymphoblastoid TK6 cells
Genotoxicity of selected cannabinoids in human lymphoblastoid TK6 cells
Natural non-psychoactive cannabinoids such as cannabigerol (CBG), cannabidiol (CBD), cannabichromene (CBC), cannabidivarin...
Targeting ferroptosis by natural products in pathophysiological conditions
Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement o...
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was stan...
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