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Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Preoperative versus postoperative nonsteroidal anti-inflammatory drugs in femoroacetabular impingement patients undergoing hip arthroscopy surgery: analgesic effect, joint function, patients’ satisfaction, and quality of life
Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic effects on femoroacetabular impingement (FAI) patients underg...
Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management
Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management
Chronic wound is a major clinical challenge that complicates wound healing, mainly associated with bacterial biofilms. Bac...
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in sepsis-associated acute lung injury
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA-495 axis in sepsis-associated acute lung injury
This study examined vitexin’s effect on sepsis-induced acute lung injury. We used network pharmacology and ...
Prooxidant state in anticancer drugs and prospect use of mitochondrial cofactors and anti-inflammatory agents in cancer prevention
Prooxidant state in anticancer drugs and prospect use of mitochondrial cofactors and anti-inflammatory agents in cancer prevention
An extensive body of literature has associated cancer with redox imbalance and inflammatory conditions. Thus, several stud...
Pharmaceutical aspects of JAK inhibitors: a comparative review
Pharmaceutical aspects of JAK inhibitors: a comparative review
Janus kinase inhibitors (JAKIs) are a new class of drugs used in the treatment of a heterogeneous group of diseases, mainl...
Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty
Effects of tranexamic acid on postoperative knee activity and stress, and inflammation cytokines in patients undergoing total knee arthroplasty
Total knee arthroplasty (TKA) is an effective treatment for knee osteoarthritis, with postoperative bleeding and the infla...
Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway
Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway
Capsaicin (CAP) induces transient pain sensation by activating transient receptor potential vanilloid-1 (TRPV1). However, ...
Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents
Mechanisms of action of ethyl acetate fractions of Liparis nervosa (Thunb.) Lindl. as potential central anti-nociceptive agents
Opioids/non-steroidal anti-inflammatory drugs are used to alleviate pain; however, they are expensive and can have adverse...
Anti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway
Anti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway
Progesterone plays a crucial and indispensable role in regulating immunity and attenuating inflammation. Nestorone® (...
Carvone-loaded chitosan nanoparticles alleviate joint destruction by downregulating the expression of pro, inflammatory cytokines and MMP-13 in adjuvant-induced rat model
Carvone-loaded chitosan nanoparticles alleviate joint destruction by downregulating the expression of pro, inflammatory cytokines and MMP-13 in adjuvant-induced rat model
Rheumatoid arthritis is an autoimmune illness causing deformity, edema, and joint tenderness. Its long-term treatment burd...
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
Alzheimer’s disease is a devastating neurodegenerative disorder that affects millions of people worldwide. One of th...
Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models
Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models
Berberine (BBR), an alkaloid derivative mostly found in Oregon grapes and barberry shoots, has several medical properties,...
Esculin-loaded nanoparticles ameliorate adjuvant-induced polyarthritis via subduing inflammatory and oxidative stress biomarkers in Wistar rats
Esculin-loaded nanoparticles ameliorate adjuvant-induced polyarthritis via subduing inflammatory and oxidative stress biomarkers in Wistar rats
Rheumatoid arthritis is an autoimmune disorder affecting multiple joints and requires lifelong treatment. Present study wa...
Down-regulation of interlinked inflammatory signalling cascades by ethanolic extract of Suaeda fruticosa Forssk. ex J.F. Gmel. attenuated in vivo inflammatory and nociceptive responses
Down-regulation of interlinked inflammatory signalling cascades by ethanolic extract of Suaeda fruticosa Forssk. ex J.F. Gmel. attenuated in vivo inflammatory and nociceptive responses
Juice and decoction of leaves of Suaeda fruticosa, a halophytic medicinal plant of Cholistan desert, is traditionally used...
Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?
Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?
Rheumatoid arthritis (RA) is a debilitating disease mainly treated by DMARDs. Baricitinib is one of the emerging DMARDs wi...
Fixed oil from the Caatinga palm Syagrus coronata with effect on Complete Freund’s Adjuvant (CFA)-induced arthritis
Fixed oil from the Caatinga palm Syagrus coronata with effect on Complete Freund’s Adjuvant (CFA)-induced arthritis
Syagrus coronata, a native palm tree in the Caatinga domain, produces fixed oil (ScFO) used therapeutically and dietary by...
Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Krill oil supplementation for knee pain: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials
Knee pain is a major cause of disability worldwide, particularly among the elderly. Current treatments, including nonstero...
‘Comprehensive review of emerging drug targets in traumatic brain injury (TBI): challenges and future scope
‘Comprehensive review of emerging drug targets in traumatic brain injury (TBI): challenges and future scope
Traumatic brain injury (TBI) is a complex brain problem that causes significant morbidity and mortality among people of al...
Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease
“Path to a good mood lies through the gut.” This statement seems to imply that it has long been believed that ...
Immune response and cytokine profiles in post-laminectomy pain syndrome: comparative analysis after treatment with intrathecal opioids, oral opioids, and non-opioid therapies
Immune response and cytokine profiles in post-laminectomy pain syndrome: comparative analysis after treatment with intrathecal opioids, oral opioids, and non-opioid therapies
This study explores the interaction between cytokines, cell-mediated immunity (T cells, B cells, and NK cells), and prolon...
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Mammalian zinc ectopeptidases have significant functions in deactivating neurological and hormonal peptide signals on the ...
Exploring the underlying pharmacological, immunomodulatory, and anti-inflammatory mechanisms of phytochemicals against wounds: a molecular insight
Exploring the underlying pharmacological, immunomodulatory, and anti-inflammatory mechanisms of phytochemicals against wounds: a molecular insight
Numerous cellular, humoral, and molecular processes are involved in the intricate process of wound healing. Numerous bioac...
Antinociceptive and anti-inflammatory activities of Ayapana triplinervis essential oil rich in thymohydroquinone dimethyl ether from Brazil
Antinociceptive and anti-inflammatory activities of Ayapana triplinervis essential oil rich in thymohydroquinone dimethyl ether from Brazil
Ayapana triplinervis (M.Vahl) R.M.King & H.Rob. (Asteraceae), popularly known as japana, is a tropical, aromatic s...
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials
The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials
Vitamin D, known for its role in bone health, is now being explored for its immunomodulatory effects. This study aimed to ...
Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses
Down-regulation of NF-κB signalling by methanolic extract of Viola odorata (L.) attenuated in vivo inflammatory and angiogenic responses
Intractable inflammation plays a key role in the progression of autoimmune diseases such as rheumatoid arthritis. Oedema a...
Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-κb pathway and the reactive oxygen species-related Nrf2 signaling pathway
Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-κb pathway and the reactive oxygen species-related Nrf2 signaling pathway
Inflammatory diseases often result in bone loss due to persistent inflammation, which activates osteoclasts and increases ...
Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?
Apigenin and inflammation in the brain: can apigenin inhibit neuroinflammation in preclinical models?
Apigenin is a flavone-kind of flavonoid present in fruits and vegetables. Apigenin exhibits biological activities includin...
Natural products: A potential immunomodulators against inflammatory-related diseases
Natural products: A potential immunomodulators against inflammatory-related diseases
The incidence and prevalence of inflammatory-related diseases (IRDs) are increasing worldwide. Current approved treatments...
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating in...
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