Ali M, Wani SUD, Salahuddin M, Dey T, Zargar MI, Singh J (2023) Recent advance of herbal medicines in cancer-a molecular approach. Heliyon 9(2)
An L, Li Z, Shi L, Wang L, Wang Y, Jin L, Shuai X, Li J (2020) Inflammation-targeted celastrol nanodrug attenuates collagen-induced arthritis through NF-κB and Notch1 pathways. Nano Lett 20(10):7728–7736
Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB, O’Shea JJ, Moudgil KD (2015) Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ. Clin Immunol 157(2):228–238
CAS PubMed PubMed Central Google Scholar
Cascao R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca J, Moita L (2012) Effective treatment of rat adjuvant-induced arthritis by celastrol. Autoimmun Rev 11(12):856–862
CAS PubMed PubMed Central Google Scholar
Cascão R, Vidal B, Lopes IP, Paisana E, Rino J, Moita LF, Fonseca JE (2015) Decrease of CD68 synovial macrophages in celastrol treated arthritic rats. PLoS ONE 10(12):e0142448
PubMed PubMed Central Google Scholar
Cascão R, Vidal B, Finnilä MAJ, Lopes IP, Teixeira RL, Saarakkala S, Moita LF, Fonseca JE (2017) Effect of celastrol on bone structure and mechanics in arthritic rats. RMD Open 3(2):e000438
PubMed PubMed Central Google Scholar
Cascão R, Vidal B, Carvalho T, Lopes IP, Romão VC, Goncalves J, Moita LF, Fonseca JE (2020) Celastrol efficacy by oral administration in the adjuvant-induced arthritis model. Front Med 7:455
Chauhan P, Pandey P, Ramniwas S, Verma M, Ganeshan S, Rajotiya S., Devi S, Lakhanpal S, Kumar MR, Pandey S (2025) Unveiling the anticancer potential of phytocompounds: pioneering future cancer therapies. Curr Top Med Chem
Chen S-R, Dai Y, Zhao J, Lin L, Wang Y, Wang Y (2018) A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F. Front Pharmacol 9:104
PubMed PubMed Central Google Scholar
Finckh A, Gilbert B, Hodkinson B, Bae S-C, Thomas R, Deane KD, Alpizar-Rodriguez D, Lauper K (2022) Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol 18(10):591–602
Gan K, Xu L, Feng X, Zhang Q, Wang F, Zhang M, Tan W (2015) Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW2647. Int Immunopharmacol 24(2):239–246
Gao Q, Qin H, Zhu L, Li D, Hao X (2020) Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Int Immunopharmacol 84:106527
Hansen CW, Nørgaard MW, de Thurah A, Midtgaard J, Cromhout PF, Esbensen BA (2024) Significant others in inflammatory arthritis: roles, influences, and challenges—a scoping review. Rheumatol Int 44(10):1849–1859
PubMed PubMed Central Google Scholar
Hou W, Liu B, Xu H (2020) Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. Eur J Med Chem 189:112081
Hua P, Liang R, Yang S, Tu Y, Chen M (2024) Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis. Bioact Mater 36:83–95
CAS PubMed PubMed Central Google Scholar
Iqbal U, Malik A, Ibrahim L, Sial NT, Mehmood MH (2025) Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation. Naunyn-Schmiedeberg's Arch Pharmacol, pp 1–18
Jing M, Yang J, Zhang L, Liu J, Xu S, Wang M, Zhang L, Sun Y, Yan W, Hou G (2021) Celastrol inhibits rheumatoid arthritis through the ROS-NF-κB-NLRP3 inflammasome axis. Int Immunopharmacol 98:107879
Johnson KJ, Sanchez HN, Schoenbrunner N (2019) Defining response to TNF-inhibitors in rheumatoid arthritis: the negative impact of anti-TNF cycling and the need for a personalized medicine approach to identify primary non-responders. Clin Rheumatol 38(11):2967–2976
Kakehasi AM, Duarte ALBP, Brenol CV, Domiciano DS, Laurindo IMM, Bonfiglioli KR, Mota LMH, Buch MH, Macêdo EA, Xavier RM (2024) Challenges in implementing treat-to-target in rheumatoid arthritis: a perspective from Brazilian rheumatologists. Adv Rheumatol 64:63
Lin S, Wang D, Xu C, Zhang P, Gao K, Liu C, Mei X (2022) Therapy of rheumatoid arthritis by reactive oxygen species-responsive celastrol-loaded nanomedicines via targeting macrophages apoptosis. Mater des 224:111298
Marahatha R, Gyawali K, Sharma K, Gyawali N, Tandan P, Adhikari A, Timilsina G, Bhattarai S, Lamichhane G, Acharya A (2021) Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials. Phytother Res 35(9):5103–5124
Mohanty SS, Sahoo CR, Paidesetty SK, Padhy RN (2023) Role of phytocompounds as the potential anti-viral agent: an overview. Naunyn Schmiedebergs Arch Pharmacol 396(10):2311–2329
Nanjundaiah SM, Venkatesha SH, Yu H, Tong L, Stains JP, Moudgil KD (2012) Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk. J Biol Chem 287(26):22216–22226
CAS PubMed PubMed Central Google Scholar
Nazir MM, Farzeen I, Fasial S, Ashraf A (2024) Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models. Inflammopharmacology pp 1–15
Parums DV (2021) Review articles, systematic reviews, meta-analysis, and the updated preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines. Med Sci Monitor Int Med J Exp Clin Res 27:e934475–e934471
Prasad P, Verma S, Surbhi X, Ganguly NK, Chaturvedi V, Mittal SA (2023) Rheumatoid arthritis: advances in treatment strategies. Mole Cell Biochem 478(1):69–88
Radu A-F, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells 10(11):2857
CAS PubMed PubMed Central Google Scholar
Ren H, Wu Z, Li J, Zhang N, Nah CY, Li J, Zhang J, Lovell JF, Zhang L, Zhang Y (2024) A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice. Bmemat 2(4):e12104
Riaz M, Khalid R, Afzal M, Anjum F, Fatima H, Zia S, Rasool G, Egbuna C, Mtewa AG, Uche CZ (2023) Phytobioactive compounds as therapeutic agents for human diseases: a review. Food Sci Nutr 11(6):2500–2529
PubMed PubMed Central Google Scholar
Si J, Guo R, Zhang L, Liu W, Kong L, Liu Y, Yu Y, Zang J, Chen W, Li X (2024) Mannose-modified celastrol liposomes targeted activated macrophages for rheumatoid arthritis treatment in vitro and in vivo evaluation. J Drug Deliv Sci Technol 91:105185
Song J, He G-N, Dai L (2023) A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomed Pharmacother 162:114705
Sparks, J. A. (2019). Rheumatoid arthritis. Annals of Internal Medicine-In the Clinic, 170(1), ITC1-ITC16e16.
Su Y, Chen R, Wang B, Wang T, Tao J, Diao Q, Jiang T, Zhao X (2025) Erythrocyte membrane camouflaged celastrol and bilirubin self-assembly for rheumatoid arthritis immunotherapy based on STING inhibition and RONS clearance. J Nanobiotechnol 23(1):318
Venkatesha SH, Yu H, Rajaiah R, Tong L, Moudgil KD (2011) Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. J Biol Chem 286(17):15138–15146
CAS PubMed PubMed Central Google Scholar
Venkatesha SH, Astry B, Nanjundaiah SM, Yu H, Moudgil KD (2012) Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines. Bioorg Med Chem 20(17):5229–5234
CAS PubMed PubMed Central Google Scholar
Wang B, Shen J, Wang X, Hou R (2024) Biomimetic nanoparticles for effective Celastrol delivery to targeted treatment of rheumatoid arthritis through the ROS-NF-κB inflammasome axis. Int Immunopharmacol 131:111822
Wong VKW, Qiu C, Xu SW, Law BYK, Zeng W, Wang H, Michelangeli F, Dias IRDSR, Qu YQ, Chan TW (2019) Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats. Br J Pharmacol 176(16):2922–2944
CAS PubMed PubMed Central Google Scholar
Xi J, Li Q, Luo X, Wang Y, Li J, Guo L, Wu G (2018) Celastrol inhibits glucocorticoid-induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways. Mol Med Rep 18(5):4753–4759
Xie T, Rui H, Liu H, Liu X, Liu X, Li P (2024) Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL/lpr mice. Lupus Sci Med 11(1):e001057
PubMed PubMed Central Google Scholar
Xu S, Feng Y, He W, Xu W, Xu W, Yang H, Li X (2021) Celastrol in metabolic diseases: Progress and application prospects. Pharmacol Res 167:105572
Yan C-Y, Ouyang S-H, Wang X, Wu Y-P, Sun W-Y, Duan W-J, Liang L, Luo X, Kurihara H, Li Y-F (2021) Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine 80:153398
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