Abuohashish HM et al (2017) ACE-2/Ang1–7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed Pharmacother 92:58–68. https://doi.org/10.1016/j.biopha.2017.05.062

Article  CAS  PubMed  Google Scholar 

Agha AM, Mansour M (2000) Effects of captopril on interleukin-6, leukotriene B(4), and oxidative stress markers in serum and inflammatory exudate of arthritic rats: evidence of antiinflammatory activity. Toxicol Appl Pharmacol 168(2):123–130. https://doi.org/10.1006/taap.2000.8985

Article  CAS  PubMed  Google Scholar 

Amaral SL et al (2001) Angiogenesis induced by electrical stimulation is mediated by angiotensin II and VEGF. Microcirculation 8(1):57–67

CAS  PubMed  Google Scholar 

Arsenault P et al (2018) NEO6860, modality-selective TRPV1 antagonist: a randomized, controlled, proof-of-concept trial in patients with osteoarthritis knee pain. Pain Rep 3(6):e696. https://doi.org/10.1097/PR9.0000000000000696

Article  PubMed  PubMed Central  Google Scholar 

Azouz AA, Saleh E, Abo-Saif AA (2020) Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund’s adjuvant arthritis model: downregulation of IL-6/JAK2/STAT3 signaling pathway. Saudi Pharm J 28(9):1101–1111. https://doi.org/10.1016/j.jsps.2020.07.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai L, Zhang Y, Wang P et al (2022) Improved diagnosis of rheumatoid arthritis using an artificial neural network. Sci Rep 12:9810. https://doi.org/10.1038/s41598-022-13750-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benigni A, Cassis P, Remuzzi G (2010) Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med 2(7):247–257. https://doi.org/10.1002/emmm.201000080

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhoola KD, Elson CJ, Dieppe PA (1992) Kinins–key mediators in inflammatory arthritis? Br J Rheumatol 31(8):509–518. https://doi.org/10.1093/rheumatology/31.8.509

Article  CAS  PubMed  Google Scholar 

Bird HA et al (1990) A clinical and biochemical assessment of a nonthiol ACE inhibitor (pentopril; CGS-13945) in active rheumatoid arthritis. J Rheumatol 17(5):603–608

CAS  PubMed  Google Scholar 

Boffetta P, Collatuzzo G (2022) Application of P4 (predictive, preventive, personalized, participatory) approach to occupational medicine. Med Lav 113(1):e2022009. https://doi.org/10.23749/mdl.v113i1.12622

Article  PubMed  PubMed Central  Google Scholar 

Braz NFT et al (2021) Renin-angiotensin system molecules are associated with subclinical atherosclerosis and disease activity in rheumatoid arthritis. Mod Rheumatol 31(1):119–126. https://doi.org/10.1080/14397595.2020.1740418

Article  CAS  PubMed  Google Scholar 

Bruyère O et al (2014) Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. Rheumatology (Oxford) 53(8):1457–1464. https://doi.org/10.1093/rheumatology/keu018

Article  PubMed  Google Scholar 

Burnier M, Brunner HR (2000) Angiotensin II receptor antagonists. Lancet 355(9204):637–645. https://doi.org/10.1016/s0140-6736(99)10365-9

Article  CAS  PubMed  Google Scholar 

Caspritz G, Alpermann HG, Schleyerbach R (1986) Influence of the new angiotensin converting enzyme inhibitor ramipril on several models of acute inflammation and the adjuvant arthritis in the rat. Arzneimittelforschung 36(11):1605–1608

CAS  PubMed  Google Scholar 

Chen T et al (2021) Update on novel non-operative treatment for osteoarthritis: current status and future trends. Front Pharmacol 12:755230. https://doi.org/10.3389/fphar.2021.755230

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cobankara V et al (2005) Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis. Rheumatol Int 25(4):285–291. https://doi.org/10.1007/s00296-004-0564-8

Article  CAS  PubMed  Google Scholar 

Coelho dos Santos JS et al (2010) Captopril increases the intensity of monocyte infection by Trypanosoma cruzi and induces human T helper type 17 cells. Clin Exp Immunol 162(3):528–536. https://doi.org/10.1111/j.1365-2249.2010.04270.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conaghan PG et al (2020) Disease-modifying effects of a novel Cathepsin K inhibitor in osteoarthritis: a randomized controlled trial. Ann Intern Med 172(2):86–95. https://doi.org/10.7326/M19-0675

Article  PubMed  Google Scholar 

Da Silveira KD et al (2010) Anti-inflammatory effects of the activation of the angiotensin-(1–7) receptor, MAS, in experimental models of arthritis. J Immunol 185(9):5569–5576. https://doi.org/10.4049/jimmunol.1000314

Article  CAS  PubMed  Google Scholar 

Dalbeth N et al (2005) The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford) 44(1):24–31. https://doi.org/10.1093/rheumatology/keh398

Article  CAS  PubMed  Google Scholar 

De Jong HJ et al (2012) Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug users. Pharmacoepidemiol Drug Saf 21(8):835–843. https://doi.org/10.1002/pds.3291

Article  CAS  PubMed  Google Scholar 

Del Rey MJ et al (2009) Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia‐inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum 60(10):2926–2934. https://doi.org/10.1002/art.24844

Article  CAS  PubMed  Google Scholar 

Deveza LA et al (2018) Efficacy of bisphosphonates in specific knee osteoarthritis subpopulations: protocol for an OA trial bank systematic review and individual patient data meta-analysis. BMJ Open 8(12):e023889. https://doi.org/10.1136/bmjopen-2018-023889

Article  PubMed  PubMed Central  Google Scholar 

Dzau VJ (1988) Circulating versus local renin–angiotensin system in cardiovascular homeostasis. Circulation 77(6 Pt 2):I4-13

CAS  PubMed  Google Scholar 

Evans CH, Kraus VB, Setton LA (2014) Progress in intra-articular therapy. Nat Rev Rheumatol 10(1):11–22. https://doi.org/10.1038/nrrheum.2013.159

Article  CAS  PubMed  Google Scholar 

Fahmy Wahba MG, Shehata Messiha BA, Abo-Saif AA (2015) Ramipril and haloperidol as promising approaches in managing rheumatoid arthritis in rats. Eur J Pharmacol 765:307–315. https://doi.org/10.1016/j.ejphar.2015.08.026

Article  CAS  PubMed  Google Scholar 

Fernandez LA, Twickler J, Mead A (1985) Neovascularization produced by angiotensin II. J Lab Clin Med 105(2):141–145

CAS  PubMed  Google Scholar 

Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438(7070):967–974. https://doi.org/10.1038/nature04483

Article  CAS  PubMed  Google Scholar 

Ferrario CM et al (2014) An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci (Lond) 126(7):461–469. https://doi.org/10.1042/CS20130400

Article  CAS  PubMed  Google Scholar 

Flammer AJ et al (2008) Angiotensin-converting enzyme inhibition improves vascular function in rheumatoid arthritis. Circulation 117(17):2262–2269.