Ahmad MH, Fatima M, Mondal AC (2019) Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: rational insights for therapeutic approaches. J Clin Neurosci 59:6–11. https://doi.org/10.1016/j.jocn.2018.10.034

Article  CAS  PubMed  Google Scholar 

Aleksijević LH, Aleksijević M, Škrlec I, Šram M, Šram M, Talapko J (2022) Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases. Pathogens (Basel, Switzerland) 11(10):1173. https://doi.org/10.3390/pathogens11101173

Article  Google Scholar 

Alvarenga MOP, Frazão DR, Matos IG, Bittencourt LO, Fagundes NCF, Rösing CK et al (2021) Is there any association between neurodegenerative diseases and periodontitis? A systematic review. Front Aging Neurosci 13:651437. https://doi.org/10.3389/fnagi.2021.651437

Article  PubMed  PubMed Central  Google Scholar 

Alzheimer’s Association (2016) 2016 Alzheimer's disease facts and figures. Alzheimer's Dementia 12(4):459–509. https://doi.org/10.1016/j.jalz.2016.03.001

Alzheimer’s Disease International. (n.d.). Dementia statistics. Retrieved June 21, 2025, from https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/

Ampadu J, Morley JE (2015) Heart failure and cognitive dysfunction. Int J Cardiol 178:12–23. https://doi.org/10.1016/j.ijcard.2014.10.087

Article  PubMed  Google Scholar 

Auffret M, Meuric V, Boyer E, Bonnaure Mallet M, Vérin M (2021) Oral health disorders in Parkinson’s disease: more than meets the eye. J Parkinsons Dis 11(4):1507–1535. https://doi.org/10.3233/JPD-212605

Article  PubMed  PubMed Central  Google Scholar 

Bertram L, Tanzi RE (2005) The genetic epidemiology of neurodegenerative disease. J Clin Invest 115(6):1449–1457. https://doi.org/10.1172/JCI24761

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian M, Chen L, Lei L (2022) Research progress on the relationship between chronic periodontitis and Parkinson’s disease. Zhejiang Da Xue Xue Bao Yi Xue Ban 51(1):108–114. https://doi.org/10.3724/zdxbyxb-2021-0111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brahmbhatt Y, Alqaderi H, Chinipardaz Z (2024) Association between severe periodontitis and cognitive decline in older adults. Life (Basel) 14(12):1589. https://doi.org/10.3390/life14121589

Article  CAS  PubMed  Google Scholar 

Brown RC, Lockwood AH, Sonawane BR (2005) Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect 113(9):1250–1256. https://doi.org/10.1289/ehp.7567

Article  PubMed  PubMed Central  Google Scholar 

Buccellato FR, Galimberti D, Tartaglia GM (2024) Beyond dentistry: could prevention and screening for neurodegenerative diseases start in the dental office? Neural Regen Res 19(1):156–157. https://doi.org/10.4103/1673-5374.375323

Article  PubMed  Google Scholar 

Cavaliere F, Gülöksüz S (2022) Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm. Npj Mental Health Res 1(1):20. https://doi.org/10.1038/s44184-022-00018-3

Article  Google Scholar 

Chen Y, Jin Y, Li K, Qiu H, Jiang Z, Zhu J et al (2023) Is there an association between Parkinson’s disease and periodontitis? A systematic review and meta-analysis. J Parkinsons Dis 13(7):1107–1125. https://doi.org/10.3233/JPD-230059

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chi L, Cheng X, Lin L, Yang T, Sun J, Feng Y et al (2021) Porphyromonas gingivalis-induced cognitive impairment is associated with gut dysbiosis, neuroinflammation, and glymphatic dysfunction. Front Cell Infect Microbiol 11:755925. https://doi.org/10.3389/fcimb.2021.755925

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortexyme Inc. (2023). COR588 Phase 1 results presented at AAIC 2023. Alzheimer’s Association International Conference (AAIC).

DiBello V, D’Ambrosio A, Baldassarre D, Silani V (2024) Periodontal disease and the risk of cognitive disorders: a systematic review and meta-analysis. Geroscience 46(2):455–472. https://doi.org/10.1007/s11357-024-00927-8

Article  Google Scholar 

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A et al (2019) Porphyromonas gingivalis in Alzheimer’s disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv 5(1):eaau3333. https://doi.org/10.1126/sciadv.aau3333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dziedzic A (2022) Is periodontitis associated with age related cognitive impairment? A systematic review, confounders assessment and meta analysis of clinical studies. Int J Mol Sci 23:15320. https://doi.org/10.3390/ijms232315320

Article  PubMed  PubMed Central  Google Scholar 

European Patent No. EP 1985626 B1 (2012) Composition antigénique de P. gingivalis. European Patent Office

Guo H, Chang S, Pi X, Hua F, Jiang H, Liu C et al (2021) The effect of periodontitis on dementia and cognitive impairment: a meta-analysis. Int J Environ Res Public Health 18(13):6823. https://doi.org/10.3390/ijerph18136823

Article  PubMed  PubMed Central  Google Scholar 

Holtzman DM, Morris JC, Goate AM (2011) Alzheimer’s disease: the challenge of the second century. Sci Transl Med 3(77):77sr1. https://doi.org/10.1126/scitranslmed.3002369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Chen Q, Zhang X, Liu Y (2025) Porphyromonas gingivalis-induced periodontitis promotes cognitive dysfunction via neuroinflammatory and tau-related pathways in rodents. Front Neurosci 19:10542. https://doi.org/10.3389/fnins.2025.10542

Article  Google Scholar 

Hussain R, Zubair H, Pursell S, Shahab M (2018) Neurodegenerative diseases: regenerative mechanisms and novel therapeutic approaches. Brain Sci 8(9):177. https://doi.org/10.3390/brainsci8090177

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ide M, Harris M, Stevens A, Sussams R, Hopkins V, Culliford D et al (2016) Periodontitis and cognitive decline in Alzheimer’s disease. PLoS ONE 11(3):e0151081. https://doi.org/10.1371/journal.pone.0151081

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ilievski V, Zuchowska PK, Green SJ, Toth PT, Ragozzino ME, Le K, Aljewari HW, O’Brien Simpson NM, Reynolds EC, Watanabe K (2018a) Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PLoS ONE 13(10):e0204941. https://doi.org/10.1371/journal.pone.0204941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishida N, Ishihara Y, Fujimura N (2020) Lipopolysaccharide from Porphyromonas gingivalis induces Aβ42 production and inflammatory response in microglia. J Neuroinflammation 17:267. https://doi.org/10.1186/s12974-020-01936-5

Article  Google Scholar 

Iwasaki M, Taylor GW, Manz MC, Yoshihara A (2019) Longitudinal relationship between periodontal disease and mild cognitive impairment in older Japanese adults. J Alzheimers Dis 72(1):337–347. https://doi.org/10.3233/JAD-190521

Article  Google Scholar 

Jiang M, Zhang X, Yan X, Mizutani S, Kashiwazaki H, Ni J, Wu Z (2021) GSK3β is involved in promoting Alzheimer’s disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor protein NL F/NL F knock-in mice. Brain Behav Immun 98:1–12. https://doi.org/10.1016/j.bbi.2021.08.213

Article  PubMed  PubMed Central  Google Scholar 

Karkowska-Kuleta J, Surowiec M, Gogol M, Koziel J, Potempa B, Potempa J, Kozik A, Rapala-Kozik M (2020) Peptidylarginine Deiminase of Porphyromonas gingivalis Modulates the Interactions between Candida albicans Biofilm and Human Plasminogen and High-Molecular-Mass Kininogen. Int J Mol Sci 21(7):2495

CAS  PubMed  PubMed Central  Google Scholar 

Kwon T, Lamster IB, Levin L (2021) Current concepts in the management of periodontitis. Int Dent J 71(6):462–476. https://doi.org/10.1111/idj.12630

Article  PubMed  PubMed Central  Google Scholar 

Li J, Thompson LM, Garcia RI, Nguyen KA (2025) Association between periodontitis and cognitive impairment in U.S. older adults: a cross-sectional cohort study. J Clin Exp Gerontol 38(2):122–130. https://doi.org/10.1016/j.jcgero.2025.01.004

Article