Almeida LE, Caporal K, Ambros V et al (2015) Immunohistochemical expression of matrix metalloprotease-2 and matrix metalloprotease-9 in the disks of patients with temporomandibular joint dysfunction. J Oral Pathol Med 44:75–79. https://doi.org/10.1111/jop.12213
Babaei-Ghazani A, Najarzadeh S, Mansoori K et al (2018) The effects of ultrasound-guided corticosteroid injection compared to oxygen–ozone (O2–O3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clin Rheumatol 37:2517–2527. https://doi.org/10.1007/s10067-018-4147-6
Berenbaum F, Walker C (2020) Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns. Postgrad Med 132:377–384. https://doi.org/10.1080/00325481.2020.1730669
Cauwe B, Opdenakker G (2010) Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases. Crit Rev Biochem Mol Biol 45:351–423. https://doi.org/10.3109/10409238.2010.501783
Chen H, Yu B, Lu C, Lin Q (2013) The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Rheumatol Int 33:1223–1227. https://doi.org/10.1007/s00296-012-2529-7
Chen Z, Liu X, Yu G et al (2016) Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats. Ren Fail 38:822–830. https://doi.org/10.3109/0886022X.2016.1143757
Costa T, Rodrigues-Manica S, Lopes C et al (2018) Ozone therapy in knee osteoarthritis: a systematic review. Acta Med Port 31:576–580. https://doi.org/10.20344/amp.10330
Daif ET (2012) Role of intra-articular ozone gas injection in the management of internal derangement of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol 113:e10–e14. https://doi.org/10.1016/j.tripleo.2011.08.006
de Lopes Jesus CC, dos Santos FC, de Jesus LMOB et al (2017) Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: a randomized, double-blinded, placebo-controlled study. PLoS ONE 12:1–16. https://doi.org/10.1371/journal.pone.0179185
de Sire A, Marotta N, Ferrillo M et al (2022) Oxygen-ozone therapy for reducing pro-inflammatory cytokines serum levels in musculoskeletal and temporomandibular disorders: a comprehensive review. Int J Mol Sci 23:1–18. https://doi.org/10.3390/ijms23052528
De Souza Tesch R, Takamori ER, Menezes K et al (2018) Temporomandibular joint regeneration: proposal of a novel treatment for condylar resorption after orthognathic surgery using transplantation of autologous nasal septum chondrocytes, and the first human case report. Stem Cell Res Ther 9:94. https://doi.org/10.1186/s13287-018-0806-4
Article PubMed PubMed Central Google Scholar
Di MR, Cantarella G, Bernardini R et al (2019) The biochemical and pharmacological properties of ozone: the smell of protection in acute and chronic diseases. Int J Mol Sci 20:1–13. https://doi.org/10.3390/ijms20030634
Doğan M, Özdemir Doğan D, Düger C et al (2014) Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Med Princ Pract 23:507–510. https://doi.org/10.1159/000365355
Article PubMed PubMed Central Google Scholar
Duymus TM, Mutlu S, Dernek B et al (2017) Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc 25:485–492. https://doi.org/10.1007/s00167-016-4110-5
Fuccio C, Luongo C, Capodanno P et al (2009) A single subcutaneous injection of ozone prevents allodynia and decreases the over-expression of pro-inflammatory caspases in the orbito-frontal cortex of neuropathic mice. Eur J Pharmacol 603:42–49. https://doi.org/10.1016/j.ejphar.2008.11.060
Galiè M, Costanzo M, Nodari A et al (2018) Mild ozonisation activates antioxidant cell response by the Keap1/Nrf2 dependent pathway. Free Radic Biol Med 124:114–121. https://doi.org/10.1016/j.freeradbiomed.2018.05.093
Galiè M, Covi V, Tabaracci G, Malatesta M (2019) The role of Nrf2 in the antioxidant cellular response to medical ozone exposure. Int J Mol Sci 20:1–15
Ge X, Ma X, Meng J et al (2009) Role of Wnt-5A in interleukin-1β-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes. Arthritis Rheum 60:2714–2722. https://doi.org/10.1002/art.24779
Gloire G, Legrand-Poels S, Piette J (2006) NF-κB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493–1505. https://doi.org/10.1016/j.bcp.2006.04.011
Hashemi M, Jalili P, Mennati S et al (2015) The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis. Anesth Pain Med 5:1–4. https://doi.org/10.5812/aapm.27585
Hashemi M, Nabi BN, Saberi A et al (2016) The comparison between two methods for the relief of knee osteoarthritis pain: radiofrequency and intra-periarticular ozone injection: a clinical trial study. Int J Med Res Health Sci 5:539–546
Hashemi M, Khameneh SMH, Mohajerani SA, Dadkhah P (2017) Effect of intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis. J Cell Mol Anesth 2(2):37–42. https://doi.org/10.22037/jcma.v2i2.16016
Invernizzi M, Stagno D, Carda S et al (2017) Safety of intra-articular oxygen-ozone therapy compared to intra-articular sodium hyaluronate in knee osteoarthritis: a randomized single blind pilot study. Int J Phys Med Rehabil 05:1–6. https://doi.org/10.4172/2329-9096.1000385
Ishimaru J-I, Oguma Y, Goss AN (2000) Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders. Br J Oral Maxillofac Surg 38:354–359. https://doi.org/10.1054/bjom.2000.0306
Kobayashi EH, Suzuki T, Funayama R et al (2016) Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun 7:1–14. https://doi.org/10.1038/ncomms11624
Lu L, Pan C, Chen L et al (2017) AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats. J Mol Cell Biol 9:132–143. https://doi.org/10.1093/jmcb/mjw043
Luo W-J, Yang F, Yang F et al (2017) Intervertebral foramen injection of ozone relieves mechanical allodynia and enhances analgesic effect of Gabapentin in animal model of neuropathic pain. Pain Physician 20:E673–E685
Machado TT, Machado ACS, Poluha RL et al (2025) The role of ozone therapy in the treatment of temporomandibular disorders: a systematic review. J Evid-Based Dental Pract 25:102127. https://doi.org/10.1016/j.jebdp.2025.102127
Marchetti C, Cornaglia I, Casasco A et al (1999) Immunolocalization of gelatinase-A (matrix metalloproteinase-2) in damaged human temporomandibular joint discs. Arch Oral Biol 44:297–304. https://doi.org/10.1016/S0003-9969(98)00107-1
Mizui T, Ishimaru JI, Miyamoto K, Kurita K (2001) Matrix metalloproteinase-2 in synovial lavage fluid of patients with disorders of the temporomandibular joint. Br J Oral Maxillofac Surg 39:310–314. https://doi.org/10.1054/bjom.2001.0634
Raeissadat SA, Rayegani SM, Forogh B et al (2018) Intra-articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial. J Pain Res 11:111–117. https://doi.org/10.2147/JPR.S142755
Article PubMed PubMed Central Google Scholar
Rezuş E, Burlui A, Cardoneanu A et al (2021) From pathogenesis to therapy in knee osteoarthritis: bench-to-bedside. Int J Mol Sci 22:1–24. https://doi.org/10.3390/ijms22052697
Sconza C, Respizzi S, Virelli L et al (2020) Oxygen-ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy 36:277–286. https://doi.org/10.1016/j.arthro.2019.05.043
Seyam O, Smith NL, Reid I et al (2018) Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res 8:103–110. https://doi.org/10.4103/2045-9912.241075
Comments (0)