HbA1c levels and breast cancer prognosis in women without diabetes

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

International Diabetes Federation. Facts & figures [Internet]. 2024 [cited 2024 Apr 15]. Available from: https://idf.org/about-diabetes/diabetes-facts-figures/

World Health Organization. Obesity and overweight [Internet]. 2024 [cited 2024 Jan 9]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM, Flax C, et al. Projected U.S. State-Level prevalence of adult obesity and severe obesity. N Engl J Med. 2019;381(25):2440–50.

Article  PubMed  Google Scholar 

Xiong F, Dai Q, Zhang S, Bent S, Tahir P, Van Blarigan EL, et al. Diabetes and incidence of breast cancer and its molecular subtypes: A systematic review and meta-analysis. Diabetes Metab Res Rev. 2024;40(1):e3709.

Article  CAS  PubMed  Google Scholar 

National Cancer Institute. Obesity and Cancer [Internet]. 2024 [cited 2024 Mar 18]. Available from: https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet#r23

Harborg S, Kjærgaard KA, Thomsen RW, Borgquist S, Cronin-Fenton D, Hjorth CF. New horizons: epidemiology of obesity, diabetes mellitus, and cancer prognosis. J Clin Endocrinol Metab. 2024;109(4):924–35.

Article  PubMed  Google Scholar 

Kang C, LeRoith D, Gallagher EJ. Diabetes, obesity, and breast cancer. Endocrinology. 2018;159(11):3801–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu F, Wang YF, Lu L, Liang Y, Wang Z, Hong X, et al. Comparison of anthropometric indices of obesity in predicting subsequent risk of hyperglycemia among Chinese men and women in Mainland China. Asia Pac J Clin Nutr. 2010;19(4):586–93.

PubMed  Google Scholar 

Tsilidis KK, Kasimis JC, Lopez DS, Ntzani EE, Ioannidis JPA. Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies. BMJ. 2015;350:g7607.

Article  PubMed  Google Scholar 

Ling S, Sweeting M, Zaccardi F, Adlam D, Kadam UT. Glycosylated haemoglobin and prognosis in 10,536 people with cancer and pre-existing diabetes: a meta-analysis with dose-response analysis. BMC Cancer. 2022;22(1):1048.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Zhang X, Sang H, Zhou Y, Shang C, Wang Y, et al. Effects of hyperglycemia on the progression of tumor diseases. J Exp Clin Cancer Res. 2019;38(1):327.

Article  PubMed  PubMed Central  Google Scholar 

Giugliano D, Ceriello A, Esposito K. Glucose metabolism and hyperglycemia. Am J Clin Nutr. 2008;87(1):S217–22.

Article  Google Scholar 

Erickson K, Patterson RE, Flatt SW, Natarajan L, Parker BA, Heath DD, et al. Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol. 2011;29(1):54–60.

Article  PubMed  Google Scholar 

Chang YL, Sheu WHH, Lin SY, Liou WS. Good glycaemic control is associated with a better prognosis in breast cancer patients with type 2 diabetes mellitus. Clin Exp Med. 2018;18(3):383–90.

Article  CAS  PubMed  Google Scholar 

Yoo TK, Lee MY, Lee SA, Cheong ES, Seo MH, Sung KC. Association of glycosylated hemoglobin level and Cancer-Related mortality in patients without diabetes. J Clin Med. 2022;11:19.

Article  Google Scholar 

Tobe A, Horimoto Y, Kobayashi K, Kamisada N, Hirano M. Impact of diabetes on patient outcomes in breast cancer patients. Breast Care (Basel). 2022;17(5):480–5.

Article  PubMed  Google Scholar 

Laurberg T, Witte DR, Gudbjörnsdottir S, Eliasson B, Bjerg L. Diabetes-related risk factors and survival among individuals with type 2 diabetes and breast, lung, colorectal, or prostate cancer. Sci Rep. 2024;14(1):10956.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boursi B, Giantonio BJ, Lewis JD, Haynes K, Mamtani R, Yang YX. Serum glucose and hemoglobin A1C levels at cancer diagnosis and disease outcome. Eur J Cancer. 2016;59:90–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jousheghany F, Phelps J, Crook T, Hakkak R. Relationship between level of HbA1C and breast cancer. BBA Clin. 2016;6:45–8.

Article  PubMed  PubMed Central  Google Scholar 

Joshu CE, Prizment AE, Dluzniewski PJ, Menke A, Folsom AR, Coresh J, et al. Glycated hemoglobin and cancer incidence and mortality in the atherosclerosis in communities (ARIC) study, 1990–2006. Int J Cancer. 2012;131(7):1667–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Lernmark Å, et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care. 2023;46(10):e151–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holm JB, Baggesen E, Cronin-Fenton D, Frystyk J, Bruun JM, Christiansen P, et al. Circulating C-reactive protein levels as a prognostic biomarker in breast cancer across body mass index groups. Sci Rep. 2024;14(1):14486.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Møller S, Jensen MB, Ejlertsen B, Bjerre KD, Larsen M, Hansen HB, et al. The clinical database and the treatment guidelines of the Danish breast cancer cooperative group (DBCG); its 30-years experience and future promise. Acta Oncol. 2008;47(4):506–24.

Article  PubMed  Google Scholar 

Jørgensen ME, Kristensen JK, Reventlov Husted G, Cerqueira C, Rossing P. The Danish adult diabetes registry. Clin Epidemiol. 2016;8:429–34.

Article  PubMed  PubMed Central  Google Scholar 

Antonsen K, Rosenstock CV, Lundstrøm LH. The Danish anaesthesia database. Clin Epidemiol. 2016;8:435–8.

Article  PubMed  PubMed Central  Google Scholar 

Schmidt M, Pedersen L, Sørensen HT. The Danish civil registration system as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541–9.

Article  PubMed  Google Scholar 

Sundhedsdatastyrelsen. National health registers [Internet]. [cited 2025 Feb 10]. Available from: https://english.sundhedsdatastyrelsen.dk/health-data-and-registers/national-health-registers

Regionernes Kliniske Kvalitetsudviklingsprogram. In English [Internet]. 2022 [cited 2024 Apr 11]. Available from: https://www.rkkp.dk/in-english/

Bio- and Genome Bank Denmark. Bio- and Genome Bank Denmark [Internet]. 2022 [cited 2024 Apr 11]. Available from: https://www.regioner.dk/rbgben

SEBIA. CAPILLARYS 3 TERA TLA [Internet]. 2024 [cited 2024 Apr 9]. Available from: https://www.sebia.com/instruments/capillarys-3-tera-tla/

Hanas R, John G. 2010 Consensus statement on the worldwide standardization of the hemoglobin A1C measurement. Diabetes Care. 2010;33(8):1903–4.

Article  PubMed  PubMed Central  Google Scholar 

Vistisen D, Witte DR, Brunner EJ, Kivimäki M, Tabák A, Jørgensen ME, et al. Risk of cardiovascular disease and death in individuals with prediabetes defined by different criteria: the Whitehall II study. Diabetes Care. 2018;41(4):899–906.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weir CB, Jan A. In: StatPearls, editor. BMI classification percentile and cut off points. Treasure Island (FL): StatPearls Publishing; 2023.

Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.

Article  CAS  PubMed  Google Scholar 

Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, et al. Breast cancer-Major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(4):290–303.

Article  PubMed  Google Scholar 

Ahn S, Woo JW, Lee K, Park SY. HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation. J Pathol Transl Med. 2020;54(1):34–44.

Article  PubMed  Google Scholar 

Sinn HP, Kreipe H. A Brief Overview of the WHO Classification of Breast Tumors, 4th Edition, Focusing on Issues and Updates from the 3rd Edition. Breast Care (Basel). 2013;8(2):149–54.

Peduzzi P, Concato J, Feinstein AR, Holford TR. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol. 1995;48(12):1503–10.

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