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Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress
Introduction: Major depressive disorder (MDD), characterized by severe neuropsychiatric symptoms and significant cognitive...
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm
IntroductionHelicobacter pylori causes chronic gastric diseases in nearly 50% of people around the world. It is suggested ...
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
Psychiatric disorders associated with fluoroquinolones: a pharmacovigilance analysis of the FDA adverse event reporting system database
BackgroundFluoroquinolones are broad-spectrum antibiotics with significant antimicrobial activity. Despite their therapeut...
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
Community pharmacists’ role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study
IntroductionThe misuse or abuse and dependence of medications containing codeine continue to be a major global public heal...
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
Capsaicin attenuates the effect of inflammatory cytokines in a HaCaT cell model for basal keratinocytes
IntroductionThe resolution of the skin’s inflammatory response is only possible if its barrier function is restored. TRPV1...
Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
Comprehensive analysis of Hibisci mutabilis Folium extract’s mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation
BackgroundSkin photoaging induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation manifests as skin roughness, de...
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
Squamous cell carcinoma of the head and neck (HNSCC) is a difficult-to-treat cancer and treatment is challenging due to re...
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis
IntroductionDiabetic ketoacidosis (DKA) is a severe and potentially fatal acute complication in diabetic patients, commonl...
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness ...
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections
There is clinical evidence showing that the Pelargonium sidoides root extract EPs 7630 is a safe and effective treatment f...
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
Computational identification of Vernonia cinerea-derived phytochemicals as potential inhibitors of nonstructural protein 1 (NSP1) in dengue virus serotype-2
BackgroundDengue virus (DENV) infection, spread by Aedes aegypti mosquitoes, is a significant public health concern in tro...
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Exploring global perspectives on the use of computer-based simulation in pharmacy education: a survey of students and educators
Background: Increasing student numbers and logistical challenges in pharmacy education limit patient counselling and clini...
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
Willingness to pay and price elasticity of demand for long-acting injectable cabotegravir among men who have sex with men in Guangxi, China
ObjectivesThere is still no study focused on willingness to pay for long-acting injectable cabotegravir (CAB-LA) after it ...
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
Nationwide usage of ethambutol and incidence and screening practices of optic neuropathy
IntroductionEthambutol, a key anti-tuberculosis medication, is associated with optic neuropathy, which can lead to signifi...
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
Naringenin modulates oxidative stress and lipid metabolism: Insights from network pharmacology, mendelian randomization, and molecular docking
BackgroundPrevious studies have demonstrated that naringenin possesses lipid-lowering effects; however, the underlying mec...
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department
IntroductionPolypharmacy is a growing concern in healthcare systems. While available data on potential drug-drug interacti...
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Radiotherapy plus lenvatinib versus radiotherapy plus sorafenib for hepatocellular carcinoma with portal vein tumor thrombus: a retrospective study
Background and AimsPortal vein tumor thrombus (PVTT) occurs frequently in hepatocellular carcinoma (HCC) patients. However...
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair
ObjectivesSingle-strand DNA-binding protein 1 (SSB1) plays a crucial role in the cellular response to DNA damage. This stu...
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
Effect of SiHuangQingXinWan on Klebsiella pneumoniae-induced pneumonia: mechanistic insights
IntroductionDue to the high mortality rate and increasing severity of antibiotic resistance, there is a growing interest i...
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
Rapid identification of chemical profiles in vitro and in vivo of Huan Shao Dan and potential anti-aging metabolites by high-resolution mass spectrometry, sequential metabolism, and deep learning model
BackgroundAging is marked by the gradual deterioration of cells, tissues, and organs and is a major risk factor for many c...
Comprehensive fecal metabolomics and gut microbiota study of the protective mechanism of herbal pair Polygonum hydropiper-Coptis chinensis in rats with stress-induced gastric mucosal damage
Comprehensive fecal metabolomics and gut microbiota study of the protective mechanism of herbal pair Polygonum hydropiper-Coptis chinensis in rats with stress-induced gastric mucosal damage
Introduction: Stress-related gastric mucosal lesions (SGMLs) are the most common complication in critical care patients. P...
Puerarin attenuates myocardial ischemic injury and endoplasmic reticulum stress by upregulating the Mzb1 signal pathway
Puerarin attenuates myocardial ischemic injury and endoplasmic reticulum stress by upregulating the Mzb1 signal pathway
ObjectiveThis study investigated the role of Mzb1 in puerarin protection against heart injury and dysfunction in acute myo...
Case report: Lichenoid eruption under immunotherapy with MK-4830 and pembrolizumab in a breast cancer patient
Case report: Lichenoid eruption under immunotherapy with MK-4830 and pembrolizumab in a breast cancer patient
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet they can induce immune-related adv...
Knowledge mapping of metformin use on cancers: a bibliometric analysis (2013–2023)
Knowledge mapping of metformin use on cancers: a bibliometric analysis (2013–2023)
There is substantial evidence from clinical and preclinical studies suggesting an association between metformin use and a ...
Assessing the real-world safety of tralokinumab for atopic dermatitis: insights from a comprehensive analysis of FAERS data
Assessing the real-world safety of tralokinumab for atopic dermatitis: insights from a comprehensive analysis of FAERS data
BackgroundTralokinumab, a humanized monoclonal antibody targeting interleukin-13, has been primarily used for the treatmen...
Impact of β-blockers on in-hospital mortality in patients with heart failure: a retrospective propensity-score matched analysis based on MIMIC-IV database
Impact of β-blockers on in-hospital mortality in patients with heart failure: a retrospective propensity-score matched analysis based on MIMIC-IV database
IntroductionThis study assessed the relationship between β-blockers treatment and in-hospital mortality among individuals ...
Phytochemistry, pharmacological effects and mechanism of action of volatile oil from Panax ginseng C.A.Mey: a review
Phytochemistry, pharmacological effects and mechanism of action of volatile oil from Panax ginseng C.A.Mey: a review
Panax ginseng (P. ginseng), a traditional and highly valued botanical drug, has been used for thousands of years and is kn...
Case report: Pyrotinib and tegafur combined with radiotherapy achieved notable response in HER2-amplified rectal cancer with multiple metastases after multiline treatments
Case report: Pyrotinib and tegafur combined with radiotherapy achieved notable response in HER2-amplified rectal cancer with multiple metastases after multiline treatments
Metastatic colorectal cancer (mCRC) is characterized by significant phenotypic heterogeneity at the molecular level and pr...
Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects
Polydatin attenuated neuropathic pain and motor dysfunction following spinal cord injury in rats by employing its anti-inflammatory and antioxidant effects
BackgroundConsidering the complex pathological mechanisms behind spinal cord injury (SCI) and the adverse effects of prese...
Efficient analysis of adverse drug events and toxicological mechanisms of newly marketed drugs by integrating pharmacovigilance and network toxicology: selumetinib as an example
Efficient analysis of adverse drug events and toxicological mechanisms of newly marketed drugs by integrating pharmacovigilance and network toxicology: selumetinib as an example
ObjectiveTo integrate pharmacovigilance and network toxicology methods to explore the potential adverse drug events (ADEs)...
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