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Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study
Persistent body-weight change on achalasia and peroral endoscopic myotomy: a multicenter cohort study
The distribution of body weight in patients with achalasia and after peroral endoscopic myotomy (POEM) has not been invest...
The landscape of 142 Epstein–Barr viral whole genomes in gastric cancer
The landscape of 142 Epstein–Barr viral whole genomes in gastric cancer
A substantial portion of gastric cancer (GC) is linked to Epstein–Barr virus (EBV) infection. The characteristics of...
Possibility of determining high quantitative fecal occult blood on stool surface using hyperspectral imaging
Possibility of determining high quantitative fecal occult blood on stool surface using hyperspectral imaging
Fecal immunochemical tests are commonly performed for colorectal cancer screening. Instant fecal occult blood measurement ...
Impact of age at HBsAg seroclearance on hepatic outcomes and life expectancy in men with chronic HBV infection based on multi-state modeling of the natural history
Impact of age at HBsAg seroclearance on hepatic outcomes and life expectancy in men with chronic HBV infection based on multi-state modeling of the natural history
The effects of age at HBsAg seroclearance on clinical outcomes and survival in chronic hepatitis B (CHB) have not been ade...
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Comparison of outcomes between surgery and chemoradiotherapy after endoscopic resection for pT1a-MM with lymphovascular invasion or pT1b esophageal squamous cell carcinoma: Japanese multicenter propensity score-matched study
Lymphovascular invasion (LVI) or pT1b is noncurative after endoscopic resection (ER) for esophageal squamous cell carcinom...
Serum zinc levels as predictors of covert hepatic encephalopathy in patients with liver cirrhosis
Serum zinc levels as predictors of covert hepatic encephalopathy in patients with liver cirrhosis
Covert hepatic encephalopathy (CHE) significantly impacts the quality of life and prognosis in patients with liver cirrhos...
Definitive-dose adjuvant radiotherapy following endoscopic submucosal dissection for superficial esophageal cancer
Definitive-dose adjuvant radiotherapy following endoscopic submucosal dissection for superficial esophageal cancer
Prophylactic chemoradiation therapy (CRT) using 40–41.4 Gy post-endoscopic submucosal dissection (ESD) for ...
Utility of Mac-2 binding protein glycosylation isomer as an excellent biomarker for the prediction of liver fibrosis, activity, and hepatocellular carcinoma onset: an expert review
Utility of Mac-2 binding protein glycosylation isomer as an excellent biomarker for the prediction of liver fibrosis, activity, and hepatocellular carcinoma onset: an expert review
Mac-2 binding protein glycosylation isomer (M2BPGi) is a liver fibrosis biomarker that originated in Japan and has been co...
Standard technique in Japan for measuring hepatic venous pressure gradient
Standard technique in Japan for measuring hepatic venous pressure gradient
Direct measurement of portal venous pressure (PVP) is invasive, so the hepatic venous pressure gradient (HVPG) is commonly...
Liver transplantation for gastroenteropancreatic neuroendocrine liver metastasis: optimal patient selection and perioperative management in the era of multimodal treatments
Liver transplantation for gastroenteropancreatic neuroendocrine liver metastasis: optimal patient selection and perioperative management in the era of multimodal treatments
Gastroenteropancreatic neuroendocrine tumors (NET) often metastasize to the liver. Although curative liver resection provi...
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study
Although specific biomarkers for primary sclerosing cholangitis (PSC) are required, no such biomarkers have been identifie...
Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection
Optimal direct oral anticoagulant for upper gastrointestinal endoscopic submucosal dissection
The patients taking direct oral anticoagulants (DOACs) are at high risk for developing ischemic stroke and delayed bleedin...
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study
A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-...
Effect of tumor microenvironment in pancreatic cancer on the loss of β-cell mass: implications for type 3c diabetes
Effect of tumor microenvironment in pancreatic cancer on the loss of β-cell mass: implications for type 3c diabetes
To explore the complex interactions between the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) an...
Migrasome-related prognostic signature TSPAN4 correlates with immune infiltrates and metabolic disturbances in hepatocellular carcinoma
Migrasome-related prognostic signature TSPAN4 correlates with immune infiltrates and metabolic disturbances in hepatocellular carcinoma
We aim to comprehensively analyze and validate the prognostic efficacy of tetraspanin 4 (TSPAN4) and several other migraso...
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Defective hepatitis C virus (HCV) genomes with deletion of the envelope region have been occasionally reported by short-re...
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Prognosis of esophageal adenocarcinoma (EAC) is still poor. Therefore, the development of novel therapeutic modalities is ...
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Overlapping clinical manifestations of irritable bowel syndrome (IBS) and IBS-like symptoms in patients with inflammatory ...
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancr...
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
Although atezolizumab plus bevacizumab (Atezo/Bev) therapy has been used as the preferred first-line treatment for advance...
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus characterized by eosinophil ac...
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Intestinal fibrosis is one of the most frequent and severe complications of Crohn’s disease. Accumulating studies ha...
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-instituti...
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Rapid skeletal muscle loss adversely affects the clinical outcomes of liver cirrhosis. However, the relationships between ...
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Wilson’s disease (WD) is a rare condition resulting from autosomal recessive mutations in ATP7B, a copper transporte...
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
The intake of high-fructose corn syrup (HFCS) may increase the risk of colorectal cancer (CRC). This study aimed to explor...
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
An artificial intelligence-based algorithm we developed, mrAI, satisfactorily segmented the rectal tumor, rectum, and meso...
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Hypoxic microenvironment is a common feature of most solid tumors including hepatocellular carcinoma (HCC). Vasculogenic m...
Association of circulating cytokine levels and tissue-infiltrating myeloid cells with achalasia: results from Mendelian randomization and validation through clinical characteristics and single-cell RNA sequencing
Association of circulating cytokine levels and tissue-infiltrating myeloid cells with achalasia: results from Mendelian randomization and validation through clinical characteristics and single-cell RNA sequencing
Achalasia is a rare motility disorder of the esophagus often accompanied by immune dysregulation, yet specific underlying ...
Genomic profile and clinical features of MSI-H and TMB-high pancreatic cancers: real-world data from C-CAT database
Genomic profile and clinical features of MSI-H and TMB-high pancreatic cancers: real-world data from C-CAT database
Microsatellite instability high (MSI-H) and tumor mutational burden high (TMB-high) pancreatic cancer are rare, and inform...
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