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Cholecystectomy following EUS-guided gallbladder drainage in patients with acute cholecystitis at high surgical risk: friend or foe?
Cholecystectomy following EUS-guided gallbladder drainage in patients with acute cholecystitis at high surgical risk: friend or foe?
We read with great interest the paper by Bang et al,1 reporting their single-centre retrospective experience in 25 patient...
Re-evaluating early-onset OSCC in Africa: findings of minimal cumulative incidence
Re-evaluating early-onset OSCC in Africa: findings of minimal cumulative incidence
We read Arnold et al’s article1 with interest and wanted to extend this work to Africa. A high incidence of oesophageal sq...
Short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?
Short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?
With great interest, we read the paper by Ammer-Hermenau et al, which features a multicentre microbiome study that include...
Proton pump inhibitors and the risk of inflammatory bowel disease: a Mendelian randomisation study
Proton pump inhibitors and the risk of inflammatory bowel disease: a Mendelian randomisation study
We read with great interest the population-based cohort study by Abrahami D et al,1 in which they found that the use of pr...
Author reply to: Exploring the impact of short-acting GLP-1 receptor agonists on GERD risk
Author reply to: Exploring the impact of short-acting GLP-1 receptor agonists on GERD risk
We appreciate the constructive dialogue from Cheng on our study’s findings.1 We agree that any clinical database study has...
Predicting treatment response in ASUC: do we measure systemic severity, organ response or both?
Predicting treatment response in ASUC: do we measure systemic severity, organ response or both?
We would like to congratulate Adams et al on the paper addressing the important issue regarding the development of prognos...
Microscopic pathology assessment of colorectal polyp size is less accurate than intracolonoscopic assessment
Microscopic pathology assessment of colorectal polyp size is less accurate than intracolonoscopic assessment
The recent study by Djinbachian et al comparing accuracy of intracolonoscopic to pathology-based assessment of colorectal ...
Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families
Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families
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Response to: short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?
Response to: short-chain fatty acids in patients with severe acute pancreatitis: friend or foe?
We write in response to the Letter to the Editor by van den Berg et al 1 commenting on our recent article ‘Gut microbiota ...
CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells
CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly lethal solid tumour with a 5-year survival rate of less th...
External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohns disease stopping infliximab
External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohns disease stopping infliximab
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Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a multicentre pragmatic randomised clinical trial
Effectiveness of mailed outreach and patient navigation to promote HCC screening process completion: a multicentre pragmatic randomised clinical trial
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TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
Video Abstract Disclaimer: this video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The...
Where are we with gastric cancer screening in Europe in 2024?
Where are we with gastric cancer screening in Europe in 2024?
Until a few years ago, the need for prevention of gastric cancer has not been prioritised in the Western world, including ...
Synergistic association of sodium-glucose cotransporter-2 inhibitor and metformin on liver and non-liver complications in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease
Synergistic association of sodium-glucose cotransporter-2 inhibitor and metformin on liver and non-liver complications in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease
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Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use
Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use
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Correction: Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
Correction: Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
Alonso-Nocelo M, Ruiz-Cañas L, Sancho P, et al. Macrophages direct cancer cells through a LOXL2-mediated metastatic casca...
Discomfort or pain: whats in a name?
Discomfort or pain: whats in a name?
Some years ago a symposium about non-invasive diagnostics attended by engineers and gastroenterologists was opened by the ...
Alzheimers disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis
Alzheimers disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis
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Thermal ablation of the resection base after endoscopic mucosal resection: a useful tool when perfect technique is not achievable
Thermal ablation of the resection base after endoscopic mucosal resection: a useful tool when perfect technique is not achievable
We welcome the excellent discussion from Mandarino et al regarding whether thermal ablation of resection base is warranted...
Severe multiple therapy refractory colitis in a 46-year-old man
Severe multiple therapy refractory colitis in a 46-year-old man
A 46-year-old male patient was referred to our tertiary care hospital with multiple therapy refractory severely active ulc...
Endoscopic mucosal resection for large non-pedunculated colorectal polyps: staying on track with a safe, effective and cost-efficient technique
Endoscopic mucosal resection for large non-pedunculated colorectal polyps: staying on track with a safe, effective and cost-efficient technique
We congratulate Djinbachian et al on their recent publication that addressed the utility of hybrid argon plasma coagulatio...
Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses
Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses
We read with interest the article by Luxenburger and Thimme, summarising current knowledge about hepatic sequelae in the c...
Efficacy of dupilumab in patients with prior exposure to topical steroids: facing second-line treatments for eosinophilic oesophagitis
Efficacy of dupilumab in patients with prior exposure to topical steroids: facing second-line treatments for eosinophilic oesophagitis
We read with interest the recent paper by Bredenoord et al,1 in which the authors performed a subgroup analysis of a phase...
Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer
Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer
We recently reported in Gut that the microbiome is unequivocally implicated in early gestational diabetes mellitus (GDM) a...
Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function
Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function
Recent papers in Gut have highlighted the importance of the genetic makeup and the influence of the gut microbiome on the ...
Human milk oligosaccharide 2-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice
Human milk oligosaccharide 2-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice
IntroductionObesity is associated with several metabolic alterations like type 2 diabetes, cardiovascular diseases and cha...
Comparison of OLGA and OLGIM as predictors of gastric cancer in a Latin American population: the ECHOS Study
Comparison of OLGA and OLGIM as predictors of gastric cancer in a Latin American population: the ECHOS Study
We read with great interest the article by Lee et al 1 evaluating the risk of progression from chronic atrophic gastritis ...
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a 5-year survival rate of merely 10%–11%.1 Pa...
Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms
Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms
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