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Digestive Disease Week 2025
From 3–6 May 2025, Nature Reviews Gastroenterology & Hepatology attended Digestive Disease Week in San Diego, USA. Acc...
Early Crohn’s disease: can we change the disease course?
Current treatments for Crohn’s disease prioritize early intervention with biological therapies, with several landmar...
The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection
The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection
Clostridioides difficile is the leading cause of antibiotic-associated diarrhoea worldwide. In the USA, C. difficile infec...
Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease
Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease
In the past decades, the pathogenic role of hepatic stellate cells (HSCs) in the development of liver fibrosis and its com...
SSRIs and depression: role of gut–brain communication
The development of antidepressant drugs was largely based on the notion that a deficiency of monoaminergic function, speci...
Redefining cancer care: the case for an onco-gastroenterology subspecialty
Redefining cancer care: the case for an onco-gastroenterology subspecialty
Onco-gastroenterology is defined as a collaborative subspecialty of Gastroenterology that is dedicated to the unique needs...
Bridging the gap: increasing MENA representation in MASLD clinical trials
Despite the Middle East and North Africa having the highest global burden of metabolic dysfunction-associated steatotic li...
Menopause and gastrointestinal health and disease
Menopause and gastrointestinal health and disease
Menopause has far-reaching effects on human physiology, including the gastrointestinal tract, and can negatively influence...
Health disparities in cirrhosis care and liver transplantation
Health disparities in cirrhosis care and liver transplantation
Morbidity and mortality from cirrhosis are substantial and increasing. Health disparities in cirrhosis and liver transplan...
Probiotics for preterms: sharing complex decision-making
Probiotics for preterms: sharing complex decision-making
Probiotics might prevent some necrotizing enterocolitis, late-onset sepsis and mortality in preterm infants. However, clin...
Transport functions of intestinal lymphatic vessels
Transport functions of intestinal lymphatic vessels
Lymphatic vessels are crucial for fluid absorption and the transport of peripheral immune cells to lymph nodes. However, i...
A new treatment and updated clinical practice guidelines for MASLD
A new treatment and updated clinical practice guidelines for MASLD
The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the firs...
Metabolic health across the ages: how microbiota members support our well-being
Metabolic health across the ages: how microbiota members support our well-being
The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial...
High-density lipoprotein lipidome: a neglected source of hepatic lipids
To define the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and identify therapeutic...
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, rev...
Transforming the landscape of liver cancer detection and care
Transforming the landscape of liver cancer detection and care
In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite...
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected b...
Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
A multicenter, open-label, controlled phase IIIb clinical trial (SEQUENCE) published in the New England Journal of Medicin...
EASL Congress 2024
In June 2024, Nature Reviews Gastroenterology & Hepatology attended in person the European Association for the Study o...
Metastatic pancreatic cancer and the liver
A recent study in Nature Medicine describes a multi-parametric profile of a pre-metastatic signature using liver biopsy sa...
Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
Liver Unit, Division of Digestive Diseases, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Research (VHIR),...
Cellular and molecular basis of proximal small intestine disorders
Cellular and molecular basis of proximal small intestine disorders
The proximal part of the small intestine, including duodenum and jejunum, is not only dedicated to nutrient digestion and ...
EPC 2024
From 26–29 June 2024, Nature Reviews Gastroenterology & Hepatology attended the 56th meeting of the European Pancreati...
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
Globally, nearly half of deaths from cirrhosis and chronic liver diseases (CLD) and three-quarters of deaths from hepatoce...
New understanding of hepatobiliary MRI
New understanding of hepatobiliary MRI
Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular c...
Improving culturally safe engagement with sexual and gender minority populations
Cultural safety seeks to remediate health inequities through empowering marginalized and minoritized patient populations, ...
Publisher Correction: Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Authors and AffiliationsAPC Microbiome Ireland, University College Cork, Cork, IrelandMaría R. Aburto & John F. CryanD...
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community co...
Promoting allyship to support and uplift the LGBTQIA+ community
Promoting allyship to support and uplift the LGBTQIA+ community
The lesbian, gay, bisexual, transgender, queer, intersex and asexual (LGBTQIA+) community navigates a complex social lands...
A crucial Fusobacterium nucleatum clade in colorectal cancer
A crucial Fusobacterium nucleatum clade in colorectal cancer
A distinct Fusobacterium nucleatum clade, Fna C2, that is dominant in the human colorectal cancer (CRC) niche has been ide...
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