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Neoadjuvant camrelizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastroesophageal junction adenocarcinoma: a single-arm, phase 2 trial
Neoadjuvant camrelizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastroesophageal junction adenocarcinoma: a single-arm, phase 2 trial
The impact of neoadjuvant combined chemotherapy, immunotherapy, and targeted therapy on pathologic responses and survival ...
The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib
The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib
Apatinib is a targeted therapy used in the treatment of advanced gastric cancer. However, many gastric cancer patients dev...
Heterogeneity of predictive biomarker expression in gastric and esophago-gastric junction carcinoma with peritoneal dissemination
Heterogeneity of predictive biomarker expression in gastric and esophago-gastric junction carcinoma with peritoneal dissemination
Temporal and spatial molecular heterogeneity contributes to resistance to targeted and immune therapies in gastric and eso...
Low positivity rate of fibroblast growth factor receptor 2b is associated with heterogeneous expression in gastric cancer
Low positivity rate of fibroblast growth factor receptor 2b is associated with heterogeneous expression in gastric cancer
Bemarituzumab, a monoclonal antibody targeting fibroblast growth factor receptor 2b (FGFR2b), is under evaluation in phase...
Development and application of deep learning-based diagnostics for pathologic diagnosis of gastric endoscopic submucosal dissection specimens
Development and application of deep learning-based diagnostics for pathologic diagnosis of gastric endoscopic submucosal dissection specimens
Accurate diagnosis of ESD specimens is crucial for managing early gastric cancer. Identifying tumor areas in serially sect...
Transformer-based skeletal muscle deep-learning model for survival prediction in gastric cancer patients after curative resection
Transformer-based skeletal muscle deep-learning model for survival prediction in gastric cancer patients after curative resection
We developed and evaluated a skeletal muscle deep-learning (SMDL) model using skeletal muscle computed tomography (CT) ima...
Long-term natural course of patients with lymph node station 6 metastasis after pylorus-preserving gastrectomy
Long-term natural course of patients with lymph node station 6 metastasis after pylorus-preserving gastrectomy
Meticulous lymph node 6 station (LN#6) dissection is mandatory in pylorus-preserving gastrectomy (PPG), but can increase t...
Function-preserving gastrectomy based on the sentinel node concept prevents osteosarcopenia in patients with gastric cancer
Function-preserving gastrectomy based on the sentinel node concept prevents osteosarcopenia in patients with gastric cancer
Gastric cancer remains a significant global challenge, with conventional surgery for early gastric cancer often leading to...
Predictive value of EBV-positivity in patients with gastric cancer treated with first-line nivolumab plus chemotherapy
Predictive value of EBV-positivity in patients with gastric cancer treated with first-line nivolumab plus chemotherapy
Epstein–Barr virus (EBV) positivity is a potential predictive biomarker for immune checkpoint inhibitors (ICIs) in g...
Early angiographic changes after hemostatic radiotherapy for gastric cancer bleeding, mentioning the mechanism and potential immediate effects of the treatment
Early angiographic changes after hemostatic radiotherapy for gastric cancer bleeding, mentioning the mechanism and potential immediate effects of the treatment
Although hemostatic radiotherapy has been reported as an effective treatment for gastric cancer bleeding, its mechanism an...
Paradoxical effects of adiposity and inflammation on immunotherapy efficacy in gastric cancer: novel insights from real-world data
Paradoxical effects of adiposity and inflammation on immunotherapy efficacy in gastric cancer: novel insights from real-world data
Emerging studies suggest obesity may improve PD-1/PD-L1 inhibitor efficacy, correlating with prolonged survival, known as ...
The RNA-binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN
The RNA-binding protein YTHDF3 affects gastric cancer cell migration and response to paclitaxel by regulating EZRIN
Gastric cancer (GC) is the fourth most common cause of cancer-related mortality and the fifth most common cancer worldwide...
A phase Ib study of photoimmunotherapy with ASP-1929 in combination with nivolumab for advanced gastric cancer (GE-PIT, EPOC1901)
A phase Ib study of photoimmunotherapy with ASP-1929 in combination with nivolumab for advanced gastric cancer (GE-PIT, EPOC1901)
Photoimmunotherapy with ASP-1929 (cetuximab conjugated to IRDye 700DX) and 690-nm red light has shown promising results, w...
Circulating tumor DNA predicts clinical benefits of immune checkpoint blockade in HER2-negative patients with advanced gastric cancer
Circulating tumor DNA predicts clinical benefits of immune checkpoint blockade in HER2-negative patients with advanced gastric cancer
Immune checkpoint inhibitors (ICIs) are becoming more prominent in the treatment of gastric cancer (GC). However, predicti...
Impact of adjuvant therapy on outcomes of cancer of the stomach and gastroesophageal junction in the real-world
Impact of adjuvant therapy on outcomes of cancer of the stomach and gastroesophageal junction in the real-world
Since the FLOT4 gastric cancer (GC) trial, the use of adjuvant chemotherapy has been perceived as limited and its added va...
Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Our Kaplan–Meier analysis reveals that gastric cancer patients with high androgen receptor (AR) expression demonstra...
Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer
Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer
Peritoneal metastasis of gastric cancer is closely associated with dismal prognosis. In previous preclinical proof-of-conc...
The molecular profile of gastric intraepithelial foveolar type neoplasia based on somatic copy number alterations and multiple mutation analysis
The molecular profile of gastric intraepithelial foveolar type neoplasia based on somatic copy number alterations and multiple mutation analysis
Gastric foveolar type neoplasia is a rare histological variant of gastric tumors. It is very difficult to differentiate be...
Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer
Lipolysis-stimulated lipoprotein receptor promote lipid uptake and fatty acid oxidation in gastric cancer
Lipolysis-stimulated lipoprotein receptor (LSR), a lipid receptor, is associated with cancer progression. However, detaile...
Genomic events stratifying prognosis of early gastric cancer
Genomic events stratifying prognosis of early gastric cancer
The purpose of the study was to conduct a comprehensive genomic characterization of gene alterations, microsatellite insta...
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer
Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer
Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate targeting HER2-positive gastric cancer or gastroesophag...
Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach
Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach
Hepatoid adenocarcinoma of the stomach (HAS), a subtype of gastric cancer (GC), includes multiple tumor components, such a...
Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01)
Morbidity and quality of life of totally laparoscopic versus laparoscopy-assisted distal gastrectomy for early gastric cancer: a multi-center prospective randomized controlled trial (CKLASS01)
There is a paucity of confirmatory randomized controlled trials (RCTs) comparing the effectiveness of totally laparoscopic...
Advantages of adjuvant chemotherapy using S-1 following minimally invasive gastrectomy for gastric cancer versus open surgery: a propensity score-matched analysis
Advantages of adjuvant chemotherapy using S-1 following minimally invasive gastrectomy for gastric cancer versus open surgery: a propensity score-matched analysis
It is essential to ensure optimal adherence to adjuvant chemotherapy regimens following gastric cancer surgery. However, t...
Short-term outcomes of a phase II trial of perioperative capecitabine plus oxaliplatin therapy for advanced gastric cancer with extensive lymph node metastases (OGSG1701)
Short-term outcomes of a phase II trial of perioperative capecitabine plus oxaliplatin therapy for advanced gastric cancer with extensive lymph node metastases (OGSG1701)
The prognosis of advanced gastric cancer (GC) with extensive lymph node (LN) metastasis treated with surgery alone remains...
Decorin as a key marker of desmoplastic cancer-associated fibroblasts mediating first-line immune checkpoint blockade resistance in metastatic gastric cancer
Decorin as a key marker of desmoplastic cancer-associated fibroblasts mediating first-line immune checkpoint blockade resistance in metastatic gastric cancer
Gastric cancer (GC) remains a significant cause of cancer-related mortality worldwide. Despite the transformative impact o...
Predictors of tolerability for postoperative adjuvant S1 plus docetaxel chemotherapy for gastric cancer: a multicenter retrospective study
Predictors of tolerability for postoperative adjuvant S1 plus docetaxel chemotherapy for gastric cancer: a multicenter retrospective study
Adjuvant docetaxel plus S1 (DS) chemotherapy after gastrectomy with D2 lymph node dissection is the standard treatment for...
Survival outcomes of patients with gastric cancer treated with first-line nivolumab plus chemotherapy based on claudin 18.2 expression
Survival outcomes of patients with gastric cancer treated with first-line nivolumab plus chemotherapy based on claudin 18.2 expression
Claudin 18.2 has emerged as a viable therapeutic target in gastric cancer; however, its clinical relevance in the context ...
A machine learning model for predicting the lymph node metastasis of early gastric cancer not meeting the endoscopic curability criteria
A machine learning model for predicting the lymph node metastasis of early gastric cancer not meeting the endoscopic curability criteria
We developed a machine learning (ML) model to predict the risk of lymph node metastasis (LNM) in patients with early gastr...
Discontinuation of neoadjuvant therapy does not influence postoperative short-term outcomes in elderly patients (≥ 70 years) with resectable gastric cancer: a population-based study from the dutch upper gastrointestinal cancer audit (DUCA) data
Discontinuation of neoadjuvant therapy does not influence postoperative short-term outcomes in elderly patients (≥ 70 years) with resectable gastric cancer: a population-based study from the dutch upper gastrointestinal cancer audit (DUCA) data
For the elderly patients with gastric cancer, it may be more challenging to tolerate complete neoadjuvant therapy (NAT). T...
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