D’Haens, G. et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial. Lancet 371, 660–667 (2008).
Colombel, J.-F. et al. Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 390, 2779–2789 (2017).
D’Haens, G. R. et al. Vedolizumab treatment is more effective and safer in early versus late Crohn’s disease: final results of the Love-CD trial. United European Gastroenterol. J. 12, OP147 (2024).
Sands, B. E. et al. Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn’s disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial. Lancet 399, 2200–2211 (2022).
Article CAS PubMed Google Scholar
Ponsioen, C. Y. et al. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: a randomised controlled, open-label, multicentre trial. Lancet Gastroenterol. Hepatol. 2, 785–792 (2017).
Stevens, T. W. et al. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol. Hepatol. 5, 900–907 (2020).
Schreiber, S. et al. Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn’s disease. J. Crohns Colitis 7, 213–221 (2013).
Article CAS PubMed Google Scholar
Cozijnsen, M. A. et al. Top-down infliximab study in kids with Crohn’s disease (TISKids): an international multicentre randomised controlled trial. BMJ Open Gastroenterol. 3, e000123 (2016).
Article CAS PubMed PubMed Central Google Scholar
Noor, N. M. et al. A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial. Lancet Gastroenterol. Hepatol. 9, 415–427 (2024).
Article CAS PubMed PubMed Central Google Scholar
Revés, J. et al. Early biological therapy within 12 months of diagnosis leads to higher transmural healing rates in Crohn’s disease. Clin. Gastroenterol. Hepatol. https://doi.org/10.1016/j.cgh.2024.07.034 (2024).
Comments (0)