Mizrahi JD, Surana R, Valle JW, et al. Pancreatic cancer. Lancet. 2020;395:2008–20.
Article CAS PubMed Google Scholar
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30.
Groot VP, Rezaee N, Wu W, et al. Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma. Ann Surg. 2018;267:936–45.
Wei SC, Duffy CR, Allison JP. Fundamental mechanisms of immune checkpoint blockade therapy. Cancer Discov. 2018;8:1069–86.
Chan TA, Yarchoan M, Jaffee E, et al. Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic. Ann Oncol. 2019;30:44–56.
Article CAS PubMed Google Scholar
Gubin MM, Artyomov MN, Mardis ER, et al. Tumor neoantigens: building a framework for personalized cancer immunotherapy. J Clin Invest. 2015;125:3413–21.
Article PubMed PubMed Central Google Scholar
Lemery S, Keegan P, Pazdur R. First FDA approval agnostic of cancer site - when a biomarker defines the indication. N Engl J Med. 2017;377:1409–12.
Marabelle A, Le DT, Ascierto PA, et al. Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer: results from the phase II KEYNOTE-158 study. J Clin Oncol. 2020;38:1–10.
Article CAS PubMed Google Scholar
Pietrantonio F, Miceli R, Raimondi A, et al. Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer. J Clin Oncol. 2019;37:3392–400.
Smyth EC, Wotherspoon A, Peckitt C, et al. Mismatch repair deficiency, microsatellite instability, and survival: an exploratory analysis of the medical research council adjuvant gastric infusional chemotherapy (MAGIC) trial. JAMA Oncol. 2017;3:1197–203.
Shulman K, Barnett-Griness O, Friedman V, et al. Outcomes of chemotherapy for microsatellite instable-high metastatic colorectal cancers. JCO Precis Oncol. 2018. https://doi.org/10.1200/PO.17.00253.
Article PubMed PubMed Central Google Scholar
Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247–57.
Article CAS PubMed PubMed Central Google Scholar
Mukai Y, Ueno H. Establishment and implementation of cancer genomic medicine in Japan. Cancer Sci. 2021;112:970–7.
Article CAS PubMed PubMed Central Google Scholar
Kohno T, Kato M, Kohsaka S, et al. C-CAT: The national datacenter for cancer genomic medicine in Japan. Cancer Discov. 2022;12:2509–15.
Article PubMed PubMed Central Google Scholar
Kundra R, Zhang H, Sheridan R, et al. OncoTree: a cancer classification system for precision oncology. JCO Clin Cancer Inform. 2021;5:221–30.
Food and Drug Administration. Summary of Safety and Effectiveness Data (FoundationOne CDx) https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170019S014B.pdf. Accessed 6 Mar 2023.
Food and Drug Administration. Summary of Safety and Effectiveness Data (FoundationOne Liquid CDx) https://www.accessdata.fda.gov/cdrh_docs/pdf19/P190032B.pdf. Accessed 6 Mar 2023.
Milbury CA, Creeden J, Yip WK, et al. Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors. PLoS ONE. 2022;17: e0264138.
Article CAS PubMed PubMed Central Google Scholar
Woodhouse R, Li M, Hughes J, et al. Clinical and analytical validation of foundationone liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin. PLoS ONE. 2020;15: e0237802.
Article CAS PubMed PubMed Central Google Scholar
Sunami K, Ichikawa H, Kubo T, et al. Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: a hospital-based study. Cancer Sci. 2019;110:1480–90.
Article CAS PubMed PubMed Central Google Scholar
Sysmex Corporation. Sysmex receives approval for a partial change to the oncoguideTM NCC oncopanel system for use in cancer genome profiling. https://www.sysmex.co.jp/en/news/2021/pdf/210215.pdf. Accessed 7 Mar 2023.
Hellmann MD, Ciuleanu TE, Pluzanski A, et al. Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N Engl J Med. 2018;378:2093–104.
Article CAS PubMed PubMed Central Google Scholar
Gröbner SN, Worst BC, Weischenfeldt J, et al. The landscape of genomic alterations across childhood cancers. Nature. 2018;555:321–7.
Campbell BB, Light N, Fabrizio D, et al. Comprehensive analysis of hypermutation in human cancer. Cell. 2017;171:1042-56.e10.
Article CAS PubMed PubMed Central Google Scholar
Pishvaian MJ, Blais EM, Brody JR, et al. Outcomes in Patients with pancreatic adenocarcinoma with genetic mutations in DNA damage response pathways: results from the know your tumor program. JCO Precis Oncol. 2019;3:1–10.
Kondo T, Kanai M, Kou T, et al. Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer. Oncotarget. 2018;9:19817–25.
Article PubMed PubMed Central Google Scholar
Singhi AD, George B, Greenbowe JR, et al. Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers. Gastroenterology. 2019;156:2242-53.e4.
Article CAS PubMed Google Scholar
Chakrabarti S, Bucheit L, Starr JS, et al. Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer. J Immunother Cancer. 2022;10:e004485.
Article PubMed PubMed Central Google Scholar
Hu ZI, Shia J, Stadler ZK, et al. Evaluating mismatch repair deficiency in pancreatic adenocarcinoma: challenges and recommendations. Clin Cancer Res. 2018;24:1326–36.
Article CAS PubMed PubMed Central Google Scholar
Luchini C, Brosens LAA, Wood LD, et al. Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications. Gut. 2021;70:148–56.
Article CAS PubMed Google Scholar
Umemoto K, Yamamoto H, Oikawa R, et al. The molecular landscape of pancreatobiliary cancers for novel targeted therapies from real-world genomic profiling. J Natl Cancer Inst. 2022;114:1279–86.
Article PubMed PubMed Central Google Scholar
Philip PA, Azar I, Xiu J, et al. Molecular characterization of KRAS wild-type tumors in patients with pancreatic adenocarcinoma. Clin Cancer Res. 2022;28:2704–14.
Article CAS PubMed PubMed Central Google Scholar
Jiao S, Xia W, Yamaguchi H, et al. PARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression. Clin Cancer Res. 2017;23:3711–20.
Article CAS PubMed PubMed Central Google Scholar
Sato H, Niimi A, Yasuhara T, et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat Commun. 2017;8:1751.
Article PubMed PubMed Central Google Scholar
Yap TA, Bardia A, Dvorkin M, et al. Avelumab plus talazoparib in patients with advanced solid tumors: the JAVELIN PARP medley nonrandomized controlled trial. JAMA Oncol. 2023;9:40–50.
Schram AM, Colombo N, Arrowsmith E, et al. Avelumab plus talazoparib in patients with BRCA1/2- or ATM-Altered advanced solid tumors: results from JAVELIN BRCA/ATM, an open-label, multicenter, phase 2b tumor-agnostic trial. JAMA Oncol. 2023;9:29–39.
Karamitopoulou E, Andreou A, Wenning AS, et al. High tumor mutational burden (TMB) identifies a microsatellite stable pancreatic cancer subset with prolonged survival and strong anti-tumor immunity. Eur J Cancer. 2022;169:64–73.
Article CAS PubMed Google Scholar
Liao C, Huang W, Lin M, et al. Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer. Int J Biol Markers. 2022;37:149–57.
Article CAS PubMed Google Scholar
Tokunaga R, Xiu J, Goldberg RM, et al. The impact of ARID1A mutation on molecular characteristics in colorectal cancer. Eur J Cancer. 2020;140:119–29.
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