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Histone H1 deamidation regulates DNA double-strand break repair
Histone H1 deamidation regulates DNA double-strand break repair
Repair of DNA double-strand breaks requires chromatin opening; however, the mechanisms involved were unclear. This work sh...
Molecular machineries shaping the mitochondrial inner membrane
Molecular machineries shaping the mitochondrial inner membrane
Mitochondria display intricately shaped deep invaginations of the mitochondrial inner membrane (MIM) termed cristae. This ...
N-glycan-dependent protein maturation and quality control in the ER
N-glycan-dependent protein maturation and quality control in the ER
The vast majority of proteins that traverse the mammalian secretory pathway become N-glycosylated in the endoplasmic retic...
Mechanisms of auxin action in plant growth and development
Mechanisms of auxin action in plant growth and development
The phytohormone auxin is a major signal coordinating growth and development in plants. The variety of its effects arises ...
Functions and therapeutic applications of pseudouridylation
Functions and therapeutic applications of pseudouridylation
The success of using pseudouridine (Ψ) and its methylation derivative in mRNA vaccines against SARS-CoV-2 has sparked...
Uncovering mRNA sequences that control translation initiation
Uncovering mRNA sequences that control translation initiation
In this Tools of the Trade article, Abdallah (Gilbert lab) describes the development of direct analysis of ribosome target...
Enabling RNA-compatible synthetic receptors through RNA editing
Enabling RNA-compatible synthetic receptors through RNA editing
In this Tools of the Trade article, Zhang and Mille-Fragoso (Gao lab) describe a synthetic receptor platform that is activ...
Structure, regulation and assembly of the photosynthetic electron transport chain
Structure, regulation and assembly of the photosynthetic electron transport chain
The electron transfer chain of chloroplast thylakoid membranes uses solar energy to split water into electrons and protons...
Transcription regulation by biomolecular condensates
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic mod...
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
Authors and AffiliationsLaboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer In...
The intraflagellar transport cycle
The intraflagellar transport cycle
Primary and motile cilia are eukaryotic organelles that perform crucial roles in cellular signalling and motility. Intrafl...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
Structural biology and molecular pharmacology of voltage-gated ion channels
Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively permeate ions across the cell membra...
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged org...
Far from the cytoplasmic crowd
Far from the cytoplasmic crowd
Stresses induce de-crowding and fluidization of the cytoplasm, which promotes the formation of biomolecular condensates.
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene expression dynamics in healthy ...
A novel photosystem assembly line worker
A novel photosystem assembly line worker
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. de...
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
The term ‘fibroblast’ often serves as a catch-all for a diverse array of mesenchymal cells, including perivasc...
Modelling tauopathies
Modelling tauopathies
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
Mechanical state transitions in the regulation of tissue form and function
Mechanical state transitions in the regulation of tissue form and function
From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues und...
Early insights into co-translational assembly of protein complexes
Early insights into co-translational assembly of protein complexes
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the earl...
In memoriam Judy Campisi: spreading cellular senescence
In memoriam Judy Campisi: spreading cellular senescence
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of ...
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