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Cardiovascular inhalation for targeted drug delivery in cardiac disease
Cardiovascular inhalation for targeted drug delivery in cardiac disease
Recombinant proteins, cell, and gene therapies are collectively defined as biological drugs or biologics. These therapies ...
Remote monitoring in heart failure: artificial intelligence and the use of remote speech analysis to detect worsening heart failure events
Remote monitoring in heart failure: artificial intelligence and the use of remote speech analysis to detect worsening heart failure events
Globally, heart failure (HF) is a leading cause of hospitalization and mortality, primarily among the elderly, and is esti...
Synchronized diaphragmatic stimulation for the treatment of HFrEF—a review
Synchronized diaphragmatic stimulation for the treatment of HFrEF—a review
The gap between maximally tolerated medical therapy and consideration for permanent mechanical circulatory support and/or ...
Sex differences in the presentation, pathophysiology, and prognosis of heart failure with preserved ejection fraction
Sex differences in the presentation, pathophysiology, and prognosis of heart failure with preserved ejection fraction
The prevalence of HFpEF is rising, especially among older females. Females possess unique attributes in their cardiovascul...
The role of finerenone in the concomitant management of chronic kidney disease-type 2 diabetes and the implication for heart failure prevention and treatment
The role of finerenone in the concomitant management of chronic kidney disease-type 2 diabetes and the implication for heart failure prevention and treatment
The nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone is indicated in the United States for use in adult...
The role of transcatheter edge-to-edge repair in functional mitral regurgitation: key takeaways from the MATTERHORN and RESHAPE-HF2 trials
The role of transcatheter edge-to-edge repair in functional mitral regurgitation: key takeaways from the MATTERHORN and RESHAPE-HF2 trials
Functional mitral regurgitation (MR) is a common complication in heart failure (HF) and remains a major contributor to adv...
Urea, TMAO, betaine and other osmolytes as endogenous diuretics in heart failure and hypertension
Urea, TMAO, betaine and other osmolytes as endogenous diuretics in heart failure and hypertension
Diuretics are essential for managing fluid overload in heart failure (HF) and controlling blood pressure in hypertension. ...
Cancer therapy-induced cardiotoxicity: mechanisms and mitigations
Cancer therapy-induced cardiotoxicity: mechanisms and mitigations
Cancer treatments like chemotherapy, radiotherapy, and combined immunotherapies have significantly increased patient survi...
Subcutaneous sensors for monitoring congestion and to reduce heart failure hospitalizations—a viable middle ground between deep implantable intravascular monitoring devices and wearable technologies?
Subcutaneous sensors for monitoring congestion and to reduce heart failure hospitalizations—a viable middle ground between deep implantable intravascular monitoring devices and wearable technologies?
Congestive heart failure (CHF) remains a leading cause of hospitalization and mortality worldwide. Continuous monitoring i...
Unveiling the complexity of nonobstructive hypertrophic cardiomyopathy
Unveiling the complexity of nonobstructive hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a genetic heart disorder defined by the presence of a maximal wall thickness of at le...
Evolving anticoagulation paradigms in left ventricular assist device (LVAD) patients: a focus on direct oral anticoagulants
Evolving anticoagulation paradigms in left ventricular assist device (LVAD) patients: a focus on direct oral anticoagulants
Anticoagulation management in patients supported by left ventricular assist devices (LVADs) is essential to prevent thromb...
Targeting inflammation in heart failure: evolving insights and future directions from randomized clinical trials
Targeting inflammation in heart failure: evolving insights and future directions from randomized clinical trials
Heart failure (HF) is a leading cause of cardiovascular morbidity and mortality, with inflammation recognized as a key cau...
Skeletal muscle atrophy in pulmonary arterial hypertension: potential mechanisms and effects of physical exercise
Skeletal muscle atrophy in pulmonary arterial hypertension: potential mechanisms and effects of physical exercise
Pulmonary arterial hypertension (PAH) is a rare and progressive disease characterized by pathological remodeling of the pu...
Time to screen: rationale and roadmap for HFpEF screening in individuals with obesity
Time to screen: rationale and roadmap for HFpEF screening in individuals with obesity
Obesity is a major risk factor for heart failure with preserved ejection fraction (HFpEF) and is associated with a distinc...
A concise guide of contemporary cardiovascular imaging practices to differentiate athlete’s heart in the gray zone
A concise guide of contemporary cardiovascular imaging practices to differentiate athlete’s heart in the gray zone
Athlete’s heart comprises various structural and functional adaptations, imposed by systematic training and intended...
Management of atrial fibrillation in patients with heart failure with preserved ejection fraction
Management of atrial fibrillation in patients with heart failure with preserved ejection fraction
Atrial fibrillation (AF) and heart failure with a preserved ejection fraction (HFpEF) frequently co-exist and are associat...
Let the drinks flow in chronic heart failure? Insights from the FRESH-UP study
Let the drinks flow in chronic heart failure? Insights from the FRESH-UP study
Heart failure (HF) is characterized by increased neurohormonal activation leading to sodium and water retention. ...
Embracing an era of targeted combination therapy for heart failure with preserved ejection fraction
Embracing an era of targeted combination therapy for heart failure with preserved ejection fraction
The concept of quadruple therapy as a "one-size-fit-all" approach is effective among all eligible patients with ...
Artificial intelligence and myocarditis—a systematic review of current applications
Artificial intelligence and myocarditis—a systematic review of current applications
Myocarditis, marked by heart muscle inflammation, poses significant clinical challenges. This study, guided by PRISMA guid...
Contemporary clinical role of echocardiography in patients with advanced heart failure
Contemporary clinical role of echocardiography in patients with advanced heart failure
Echocardiography represents an essential tool for imagers and clinical cardiologists in the management of patients with he...
Pharmacological management of heart failure in adults with congenital heart disease
Pharmacological management of heart failure in adults with congenital heart disease
Congenital heart disease (CHD) is the most common global congenital defect affecting over 2.4 million individuals in the U...
Treating heart failure by targeting the vagus nerve
Treating heart failure by targeting the vagus nerve
Increased sympathetic and reduced parasympathetic nerve activity is associated with disease progression and poor outcomes ...
Peripartum cardiomyopathy: a comprehensive and contemporary review
Peripartum cardiomyopathy: a comprehensive and contemporary review
Cardiovascular disease is a major non-communicable disease globally, with increasing prevalence, posing a significant publ...
Clinical and utilization outcomes with short stay units vs hospital admission for lower risk decompensated heart failure: a systematic review and meta-analysis
Clinical and utilization outcomes with short stay units vs hospital admission for lower risk decompensated heart failure: a systematic review and meta-analysis
With over 1 million primary heart failure (HF) hospitalizations annually, nearly 80% of patients who present to the emerge...
Congestion/decongestion in heart failure: what does it mean, how do we assess it, and what are we missing?—is there utility in measuring volume?
Congestion/decongestion in heart failure: what does it mean, how do we assess it, and what are we missing?—is there utility in measuring volume?
Clinical congestion remains a major cause of hospitalization and re-hospitalizations in patients with chronic heart failur...
Adrenal crisis-induced cardiogenic shock (ACCS): a comprehensive review
Adrenal crisis-induced cardiogenic shock (ACCS): a comprehensive review
Adrenal insufficiency (AI) is a disorder in which inadequate glucocorticoid and mineralocorticoid hormone production leads...
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established appro...
Sodium-glucose co-transporter 2 inhibitors in left ventricular assist device and heart transplant recipients: a mini-review
Sodium-glucose co-transporter 2 inhibitors in left ventricular assist device and heart transplant recipients: a mini-review
In recent years, sodium-glucose co-transporter 2 inhibitors (SGLT2i) emerged as promising therapeutic agents in managing h...
Diagnosis and management of hypertrophic cardiomyopathy: European vs. American guidelines
Diagnosis and management of hypertrophic cardiomyopathy: European vs. American guidelines
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting 1:200 to 1:500 individuals worldwide...
Maternal heart failure: state-of-the-art review
Maternal heart failure: state-of-the-art review
Pregnancy is a period of substantial changes to the body’s normal physiology, and the failure to adapt to these chan...
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