Coats AJS, Anker SD, Baumbach A, Alfieri O, von Bardeleben RS, Bauersachs J et al (2021) The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. Eur Heart J 42(13):1254–1269

Article  PubMed  PubMed Central  Google Scholar 

Sannino A, Smith RL, Schiattarella GG, Trimarco B, Esposito G, Grayburn PA (2017) Survival and cardiovascular outcomes of patients with secondary mitral regurgitation: a systematic review and meta-analysis. JAMA Cardiol 2(10):1130–1139

Article  PubMed  PubMed Central  Google Scholar 

Goliasch G, Bartko PE, Pavo N, Neuhold S, Wurm R, Mascherbauer J et al (2018) Refining the prognostic impact of functional mitral regurgitation in chronic heart failure. Eur Heart J 39(1):39–46

Article  CAS  PubMed  Google Scholar 

Stone GW, Vahanian AS, Adams DH, Abraham WT, Borer JS, Bax JJ et al (2015) Clinical trial design principles and endpoint definitions for transcatheter mitral valve repair and replacement: part 1: clinical trial design principles: a consensus document from the mitral valve academic research consortium. J Am Coll Cardiol 66(3):278–307

Article  PubMed  Google Scholar 

Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS et al (2011) Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 364(15):1395–1406

Article  CAS  PubMed  Google Scholar 

Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM et al (2018) Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med 379(24):2307–2318

Article  PubMed  Google Scholar 

Stone GW, Abraham WT, Lindenfeld J, Kar S, Grayburn PA, Lim DS et al (2023) Five-year follow-up after transcatheter repair of secondary mitral regurgitation. N Engl J Med 388(22):2037–2048

Article  PubMed  Google Scholar 

Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, Piriou N et al (2018) Percutaneous repair or medical treatment for secondary mitral regurgitation. N Engl J Med 379(24):2297–2306

Article  PubMed  Google Scholar 

Spinka G, Bartko PE, Heitzinger G, Prausmüller S, Winter MP, Arfsten H et al (2022) Guideline directed medical therapy and reduction of secondary mitral regurgitation. Eur Heart J Cardiovasc Imaging 23(6):755–764

Article  PubMed  Google Scholar 

Pagnesi M, Adamo M, Sama IE, Anker SD, Cleland JG, Dickstein K et al (2022) Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure. Clin Res Cardiol Off J Ger Card Soc 111(8):912–923

Google Scholar 

Baldus S, Doenst T, Pfister R, Gummert J, Kessler M, Boekstegers P, et al. (2024) Transcatheter repair versus mitral-valve surgery for secondary mitral regurgitation. N Engl J Med. 

Anker SD, Friede T, von Bardeleben RS, Butler J, Khan MS, Diek M, et al. (2024) Transcatheter valve repair in heart failure with moderate to severe mitral regurgitation. N Engl J Med. 31;

Ponikowski P, Friede T, von Bardeleben RS, Butler J, Shahzeb Khan M, Diek M et al (2024) Hospitalization of symptomatic patients with heart failure and moderate to severe functional mitral regurgitation treated with MitraClip: insights from RESHAPE-HF2. J Am Coll Cardiol S0735–1097(24):08233

Google Scholar 

Anker SD, Friede T, von Bardeleben RS, Butler J, Khan MS, Diek M et al (2024) Percutaneous repair of moderate-to-severe or severe functional mitral regurgitation in patients with symptomatic heart failure: baseline characteristics of patients in the RESHAPE-HF2 trial and comparison to COAPT and MITRA-FR trials. Eur J Heart Fail 26(7):1608–1615

Article  CAS  PubMed  Google Scholar 

Anker MS, Porthun J, Schulze PC, Rassaf T, Landmesser U (2024) Percutaneous transcatheter edge-to-edge repair for functional mitral regurgitation in heart failure: a meta-analysis of 3 randomized controlled trials. J Am Coll Cardiol S0735–1097(24):08231–08237

Google Scholar 

Savarese G, Basile C, Adamo M, Anker SD, Bayes-Genis A, Böhm M, et al. (2025) Registries on transcatheter edge-to-edge repair in heart failure: current evidence and future perspectives. Eur J Heart Fail. 8

Puls M, Lubos E, Boekstegers P, von Bardeleben RS, Ouarrak T, Butter C et al (2016) One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry. Eur Heart J 37(8):703–712

Article  PubMed  Google Scholar 

Kalbacher D, Schäfer U, Bardeleben V et al (2019) Long-term outcome, survival and predictors of mortality after MitraClip therapy: results from the German Transcatheter Mitral Valve Interventions (TRAMI) registry. Int J Cardiol. 277:35–41

Article  PubMed  Google Scholar 

Shuvy M, Maisano F (2024) Evolving indications for transcatheter mitral edge-to-edge repair. EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol 20(4):e230–e238

Google Scholar 

Adamo M, Tomasoni D, Stolz L, Stocker TJ, Pancaldi E, Koell B et al (2023A 24) Impact of transcatheter edge-to-edge mitral valve repair on guideline-directed medical therapy uptitration. JACC Cardiovasc Interv 16(8):896–905

Article  PubMed  Google Scholar