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Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Evaluating the Role and Policy Implications of Using External Evidence in Survival Extrapolations: A Case Study of Axicabtagene Ciloleucel Therapy for Second-Line DLBCL
Health technology assessment (HTA) of haemato-oncology therapies typically requires extrapolation of long-term survival be...
Bayesian Cost-Effectiveness Analysis Using Individual-Level Data is Sensitive to the Choice of Uniform Priors on the Standard Deviations for Costs in Log-Normal Models
Bayesian Cost-Effectiveness Analysis Using Individual-Level Data is Sensitive to the Choice of Uniform Priors on the Standard Deviations for Costs in Log-Normal Models
Bayesian cost-effectiveness analysis (CEA) requires the specification of prior distributions for all parameters to be empi...
Lifetime Healthcare and Long-Term Care Costs of Heart Failure: Estimates Using Administrative Data from Hospitalized Patients in the Netherlands
Lifetime Healthcare and Long-Term Care Costs of Heart Failure: Estimates Using Administrative Data from Hospitalized Patients in the Netherlands
Heart failure (HF) is a complex clinical syndrome associated with high mortality and extensive healthcare use. Using longi...
Developing a Comprehensive Framework for Cost-Effectiveness Evaluation in Metastatic Castration-Sensitive Prostate Cancer: Insights from a Systematic Review
Developing a Comprehensive Framework for Cost-Effectiveness Evaluation in Metastatic Castration-Sensitive Prostate Cancer: Insights from a Systematic Review
Metastatic castration-sensitive prostate cancer (mCSPC) imposes a significant economic burden and necessitates more cost-e...
Eliciting and Anchoring Health State Preferences Using Discrete Choice Experiments Among Adults, Adolescents, and Children
Eliciting and Anchoring Health State Preferences Using Discrete Choice Experiments Among Adults, Adolescents, and Children
We aimed to compare EQ-5D-Y-5L health state preferences among children, adolescents, and adults in Canada using a discrete...
Cost–Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn’s Disease
Cost–Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn’s Disease
The clinical pathway for patients with moderate-to-severe Crohn’s disease (CD) typically includes sequential pharmac...
Developing an EQ-5D-5L Value Set for Singapore
Developing an EQ-5D-5L Value Set for Singapore
The EQ-5D-5L is a multi-attribute utility instrument recommended by many health technology assessment agencies. This study...
Highlights from the Manifesto on the Health Economics of Cardiovascular Disease Prevention
Highlights from the Manifesto on the Health Economics of Cardiovascular Disease Prevention
Cardiovascular disease (CVD) is a major contributor to the health and economic burden of disease globally. In this paper w...
HTA Evidence in Rare Diseases: Just Rare or Also Special?
HTA Evidence in Rare Diseases: Just Rare or Also Special?
Manufacturers of orphan drugs face several obstacles in meeting health technology assessment requirements because of poor ...
Eco Friendly and Budget Smart: An Economic and Environmental Evaluation of Alternative PD-1 and PD-L1 Inhibitor Dosing Regimens
Eco Friendly and Budget Smart: An Economic and Environmental Evaluation of Alternative PD-1 and PD-L1 Inhibitor Dosing Regimens
Immune checkpoint inhibitors (ICIs) are clinically beneficial but associated with high costs that represent a growing chal...
Heterogeneity in Economic Value of SGLT2is for Type 2 Diabetes: Subgroup Modeling Cost-Effectiveness Analyses
Heterogeneity in Economic Value of SGLT2is for Type 2 Diabetes: Subgroup Modeling Cost-Effectiveness Analyses
Although heterogeneous treatment effects of sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been revealed, the he...
Cost-Consequence Analysis of Natalizumab Compared with Other High-Efficacy Treatments in Patients with Relapsing–Remitting Multiple Sclerosis
Cost-Consequence Analysis of Natalizumab Compared with Other High-Efficacy Treatments in Patients with Relapsing–Remitting Multiple Sclerosis
Advances in the availability and regimen optimization of highly effective disease-modifying treatments (DMTs) for relapsin...
Cost-Effectiveness Analysis of Aztreonam-Avibactam (ATM-AVI) Versus Colistin + Meropenem (COL + MER) for the Treatment of Infections Caused by Metallo-β-Lactamase (MBL)-Producing in Italy
Cost-Effectiveness Analysis of Aztreonam-Avibactam (ATM-AVI) Versus Colistin + Meropenem (COL + MER) for the Treatment of Infections Caused by Metallo-β-Lactamase (MBL)-Producing in Italy
Aztreonam-avibactam (ATM-AVI) is a novel combination antibiotic approved in Europe for the treatment of complicated intra-...
Eladocagene Exuparvovec for the Treatment of Aromatic -Amino Acid Decarboxylase Deficiency (AADCd): An Economic Evaluation from a US Perspective
Eladocagene Exuparvovec for the Treatment of Aromatic -Amino Acid Decarboxylase Deficiency (AADCd): An Economic Evaluation from a US Perspective
Recently, the gene therapy eladocagene exuparvovec received accelerated approval from the US Food and Drug Administration ...
Exploring the Generalizability of Foreign Cost-Effectiveness Analysis to Spain Using Data From a Scoping Review of Multinational Studies
Exploring the Generalizability of Foreign Cost-Effectiveness Analysis to Spain Using Data From a Scoping Review of Multinational Studies
This study examines the generalizability of foreign economic evaluations to the Spanish healthcare system. The research ai...
Scoping Review of Productivity-Adjusted Life Years (PALYs): Methods, Applications and Policy Implications
Scoping Review of Productivity-Adjusted Life Years (PALYs): Methods, Applications and Policy Implications
To understand the application of productivity-adjusted life years (PALYs) as an outcome measure across various disease con...
The Economic Burden of Inflammatory Arthritis: A Systematic Review
The Economic Burden of Inflammatory Arthritis: A Systematic Review
Inflammatory arthritis is a common condition treated in rheumatology clinics, contributing significantly to healthcare cos...
The Influence of Perspective on the Valuation of the EQ-5D-Y-3L: A Comparison Using the OPUF Tool and a Discrete Choice Experiment
The Influence of Perspective on the Valuation of the EQ-5D-Y-3L: A Comparison Using the OPUF Tool and a Discrete Choice Experiment
The choice of perspective in valuation tasks is likely to affect the scale of EQ-5D-Y-3L value sets, but less is known abo...
Patient-Level Health Economic Modeling in Excel Without VBA: A Tutorial
Patient-Level Health Economic Modeling in Excel Without VBA: A Tutorial
Cohort-level models in Microsoft Excel® remain the standard for cost-effectiveness modeling to inform health technolo...
Value-Based Healthcare in Practice: IDEATE, a Collaboration to Design and Test an Outcomes-Based Agreement for a Medicine in Wales
Value-Based Healthcare in Practice: IDEATE, a Collaboration to Design and Test an Outcomes-Based Agreement for a Medicine in Wales
To develop a sustainable, scalable methodology for the design of outcome-based agreements (OBAs) that works on the ground ...
Recurrence of Cardiovascular Events After an Acute Myocardial Infarction in Patients with Multivessel Disease and Associated Healthcare Costs: A German Claims Data Analysis
Recurrence of Cardiovascular Events After an Acute Myocardial Infarction in Patients with Multivessel Disease and Associated Healthcare Costs: A German Claims Data Analysis
This study sought to quantify the healthcare costs of multivessel disease (MVD) and determine the prevalence and incidence...
EQ-5D-5L or EQ-HWB-S: Which is the Better Instrument for Capturing Spillover Effects in Parental Carers of Children with COVID-19?
EQ-5D-5L or EQ-HWB-S: Which is the Better Instrument for Capturing Spillover Effects in Parental Carers of Children with COVID-19?
‘Caregiver health spillovers’ refer to the broader impacts of an individual’s illness and interventions ...
Towards Recommendations for Cost-Effectiveness Analysis of Predictive, Prognostic, and Serial Biomarker Tests in Oncology
Towards Recommendations for Cost-Effectiveness Analysis of Predictive, Prognostic, and Serial Biomarker Tests in Oncology
Cost-effectiveness analysis (CEA) of biomarkers is challenging due to the indirect impact on health outcomes and the lack ...
A Taxonomy for Assessing Whether HRQoL Value Sets Are Obsolete
A Taxonomy for Assessing Whether HRQoL Value Sets Are Obsolete
Providing health-related quality of life (HRQoL) value sets to enable estimation of quality adjusted life years (QALYs) is...
Cost-Effectiveness Analysis of Nirsevimab for Preventing Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease in Dutch Infants: An Analysis Including All-Infant Protection
Cost-Effectiveness Analysis of Nirsevimab for Preventing Respiratory Syncytial Virus-Related Lower Respiratory Tract Disease in Dutch Infants: An Analysis Including All-Infant Protection
This study aimed to assess the cost effectiveness of nirsevimab, a recently authorized monoclonal antibody (mAb) for the p...
Innovative Payment Models for Sickle-Cell Disease Gene Therapies in Medicaid: Leveraging Real-World Data and Insights from CMMI’s Gene Therapy Access Model
Innovative Payment Models for Sickle-Cell Disease Gene Therapies in Medicaid: Leveraging Real-World Data and Insights from CMMI’s Gene Therapy Access Model
This study aims to evaluate the financial implications of implementing various payment models, including outcome-based agr...
Making Composite Time Trade-Off Sensitive for Worse-than-Dead Health States
Making Composite Time Trade-Off Sensitive for Worse-than-Dead Health States
The utilities elicited with the composite time trade-off (cTTO) method for health states worse-than-dead (WTD) often corre...
Immediate Versus 5-Year Risk-Guided Initiation of Treatment for Primary Prevention of Cardiovascular Disease for Australians Aged 40 Years: A Health Economic Analysis
Immediate Versus 5-Year Risk-Guided Initiation of Treatment for Primary Prevention of Cardiovascular Disease for Australians Aged 40 Years: A Health Economic Analysis
Current Australian cardiovascular disease (CVD) prevention guidelines calculate 5-year CVD risk and recommend treatment wh...
A Multistate Model Incorporating Relative Survival Extrapolation and Mixed Time Scales for Health Technology Assessment
A Multistate Model Incorporating Relative Survival Extrapolation and Mixed Time Scales for Health Technology Assessment
Multistate models have been widely applied in health technology assessment. However, extrapolating survival in a multistat...
Economic Evaluations of Non-Pharmacological Interventions for Treating Disorders of Gut-Brain Interaction: A Scoping Review
Economic Evaluations of Non-Pharmacological Interventions for Treating Disorders of Gut-Brain Interaction: A Scoping Review
Disorders of gut-brain interaction are highly prevalent and burdensome conditions for both patients and healthcare systems...
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