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Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration
Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration
Cartilage diseases and injuries are considered difficult to treat owing to the low regenerative capacity of this tissue. U...
Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes
Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes
Gestational diabetes mellitus (GDM) significantly disrupts placental structure and function, leading to complications such...
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis
Preeclampsia (PE) is a severe placental complication occurring after the 20th week of pregnancy. PE is associated...
Identifying as a therapeutic target in thyroid cancer among the core circadian clock genes
Identifying as a therapeutic target in thyroid cancer among the core circadian clock genes
Previous studies have shown that thyroid malignancies can alter the transcriptional oscillations of circadian clock genes....
FAK mediates mechanical signaling to maintain epithelial homeostasis through YAP/TAZ-TEADs
FAK mediates mechanical signaling to maintain epithelial homeostasis through YAP/TAZ-TEADs
Epithelial homeostasis ensures that the epithelium can perform its normal physiological functions. Mechanical signaling re...
Expression of angiogenic factors in the mammalian senescent cell sustaining spp. muscle larvae
Expression of angiogenic factors in the mammalian senescent cell sustaining spp. muscle larvae
Muscle larvae of the mammalian parasitic nematode Trichinella spp. live in a senescent nurse cell (NC). The NC is formed f...
Replicative senescence in amniotic fluid-derived mesenchymal stem cells and its impact on their immunomodulatory properties
Replicative senescence in amniotic fluid-derived mesenchymal stem cells and its impact on their immunomodulatory properties
The expansion of mesenchymal stem cells (MSCs) for clinical applications is often limited by replicative senescence, a gro...
January In focus in HCB
January In focus in HCB
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy appears to be ass...
Wound healing and anti-inflammatory effects of LAA, the -acetyl--galactosamine-binding lectin from seeds of (Allemão) ducke
Wound healing and anti-inflammatory effects of LAA, the -acetyl--galactosamine-binding lectin from seeds of (Allemão) ducke
Cutaneous wounds represent a significant health concern, and effective treatment strategies are crucial for optimal healin...
Novel method of paraffin embedding cultured cells and organoids using silicone molds
Novel method of paraffin embedding cultured cells and organoids using silicone molds
A major issue facing the field of cellular imaging, immunofluorescence (IF), and immunohistochemistry (IHC) microscopy is ...
The code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin
The code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin
Fibroblasts, the most abundant cell type in the human body, play crucial roles in biological processes such as inflammatio...
Increased vascularization of the subchondral region in human osteoarthritic femoral head in the elderly
Increased vascularization of the subchondral region in human osteoarthritic femoral head in the elderly
This study aimed to quantitatively analyze subchondral vascularization during the progression of osteoarthritis (OA) in th...
February In focus in HCB
February In focus in HCB
Many factors are believed to be involved in the differentiation of odontoblasts located in the dental pulp as they assist ...
Red deer ( L.) antler stem cell culture medium inhibits prostate cancer cells
Red deer ( L.) antler stem cell culture medium inhibits prostate cancer cells
Prostate cancer is a frequently diagnosed cancer in men, but today the prognosis of local cancer and its metastasis has im...
Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect
Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect
Peroxisomes have gained increasing attention and are now considered vital players in normal physiological functions. To ga...
Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis
Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis
Pulmonary fibrosis (PF) is an insidious, progressive, and fatal age-associated disease that occurs primarily in older adul...
Differentiated muscle cells of salamander re-enter the cell cycle
Differentiated muscle cells of salamander re-enter the cell cycle
Salamander Pleurodeles waltl is an emerging animal model for developmental and regenerative biology studies. However, the ...
HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway
HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway
The pathophysiology of hypertrophic scar (HS) shares similarities with cancer. HOXC10, a gene significantly involved in ca...
Somatostatin-immunoreactive neurons of the rat gut during the development
Somatostatin-immunoreactive neurons of the rat gut during the development
Somatostatin (SST) is a peptide expressed in the peripheral and central nervous systems, as well as in endocrine and immun...
An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
DNA damage is one of the most important effects induced by chemical agents. We report a comparative analysis of DNA fragme...
Complex shape markers can detect alterations in the spatial distribution of cell nuclei in human lung squamous cell carcinoma: a useful tool for automatic analysis?
Complex shape markers can detect alterations in the spatial distribution of cell nuclei in human lung squamous cell carcinoma: a useful tool for automatic analysis?
Lung cancer is the leading cause of cancer-related death. The use of computational methods to quantify changes that are no...
Identification and culture of functional salivary gland ductal epithelial cells
Identification and culture of functional salivary gland ductal epithelial cells
Sialadenitis is a prevalent salivary gland disease resulting in decreased salivary flow rate. To date, little is known abo...
Expression of mRNA for molecules that regulate angiogenesis, endothelial cell survival, and vascular permeability is altered in endothelial cells isolated from db/db mouse hearts
Expression of mRNA for molecules that regulate angiogenesis, endothelial cell survival, and vascular permeability is altered in endothelial cells isolated from db/db mouse hearts
Metabolic syndrome (MetS) is a condition that includes symptoms, such as obesity, hyperglycemia, and hypertension, which e...
Anti-inflammatory and glial response maintain normal colon function in trimethyltin-treated rats
Anti-inflammatory and glial response maintain normal colon function in trimethyltin-treated rats
Studies on the contribution of enteric neuropathy and intestinal homeostasis to central nervous system degeneration using ...
Specificity of widely used lectins as probed with oligosaccharide and plant polysaccharide arrays
Specificity of widely used lectins as probed with oligosaccharide and plant polysaccharide arrays
Glycan-binding specificity was studied for Jacalin, RCA 120, SBA, PHA-L, PHA-E, WGA, UEA, AAL, LTL, LEL, SNA, DSA, LCA, MA...
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
The use of cold formalin fixation (CFF; i.e., fixating tissue samples with 4 °C precooled formalin) recently...
Expression of SARS-CoV-2 entry molecules ACE2, NRP1, TMPRSS2, and FURIN in the reproductive tissues of male macaques
Expression of SARS-CoV-2 entry molecules ACE2, NRP1, TMPRSS2, and FURIN in the reproductive tissues of male macaques
Coronavirus disease 2019 (COVID-19) reportedly affects male reproductive function by causing spermatogenesis dysfunction a...
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study
Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the...
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. M...
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Mast cells (MCs) in rat airways have been classified into two subtypes: epithelial MCs and connective tissue MCs (CTMCs). ...
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