Replicative senescence in amniotic fluid-derived mesenchymal stem cells and its impact on their immunomodulatory properties

Acuna-Hidalgo R, Veltman JA, Hoischen A (2016) New insights into the generation and role of de novo mutations in health and disease. Genome Biol 17(1):241

Article  PubMed  PubMed Central  Google Scholar 

Akiyama K, Chen C, Wang D, Xu X, Qu C, Yamaza T, Cai T, Chen W, Sun L, Shi S (2012) Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10(5):544–555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alt EU, Senst C, Murthy SN, Slakey DP, Dupin CL, Chaffin AE, Kadowitz PJ, Izadpanah R (2012) Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res 8(2):215–225

Article  CAS  PubMed  Google Scholar 

Atsuta I, Liu S, Miura Y, Akiyama K, Chen C, An Y, Shi S, Chen FM (2013) Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway. Stem Cell Res Ther 4(5):111

Article  PubMed  PubMed Central  Google Scholar 

Banimohamad-Shotorbani B, Kahroba H, Sadeghzadeh H, Wilson DM, Maadi H, Samadi N, Hejazi MS, Farajpour H, Onari BN, Sadeghi MR (2020) DNA damage repair response in mesenchymal stromal cells: from cellular senescence and aging to apoptosis and differentiation ability. Ageing Res Rev 62:101125

Article  CAS  PubMed  Google Scholar 

Block TJ, Marinkovic M, Tran ON, Gonzalez AO, Marshall A, Dean DD, Chen XD (2017) Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies. Stem Cell Res Ther 8(1):239

Article  PubMed  PubMed Central  Google Scholar 

Bolamperti S, Signo M, Spinello A, Moro G, Fraschini G, Guidobono F, Rubinacci A, Villa I (2018) GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling. Bone 112:136–144

Article  CAS  PubMed  Google Scholar 

Cakouros D, Gronthos S (2019) Epigenetic regulation of bone marrow stem cell aging: revealing epigenetic signatures associated with hematopoietic and mesenchymal stem cell aging. Aging Dis 10(1):174–189

Article  PubMed  PubMed Central  Google Scholar 

Cappola AR, Xue QL, Ferrucci L, Guralnik JM, Volpato S, Fried LP (2003) Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 88(5):2019–2025

Article  CAS  PubMed  Google Scholar 

Chen Z, Xia X, Yao M, Yang Y, Ao X, Zhang Z, Guo L, Xu X (2024) The dual role of mesenchymal stem cells in apoptosis regulation. Cell Death Dis 15(4):250

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiche A, Le Roux I, von Joest M, Sakai H, Aguín SB, Cazin C, Salam R, Fiette L, Alegria O, Flamant P, Tajbakhsh S, Li H (2017) Injury-induced senescence enables in vivo reprogramming in skeletal muscle. Cell Stem Cell 20(3):407-414.e404

Article  CAS  PubMed  Google Scholar 

Crane JL, Zhao L, Frye JS, Xian L, Qiu T, Cao X (2013) IGF-1 signaling is essential for differentiation of mesenchymal stem cells for peak bone mass. Bone Res 1(2):186–194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fischer M, Müller GA (2017) Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes. Crit Rev Biochem Mol Biol 52(6):638–662

Article  CAS  PubMed  Google Scholar 

Ganguly P, El-Jawhari JJ, Giannoudis PV, Burska AN, Ponchel F, Jones EA (2017) Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development. Cell Transplant 26(9):1520–1529

Article  PubMed  PubMed Central  Google Scholar 

Gao Y, Chi Y, Chen Y, Wang W, Li H, Zheng W, Zhu P, An J, Duan Y, Sun T, Liu X, Xue F, Liu W, Fu R, Han Z, Zhang Y, Yang R, Cheng T, Wei J, Zhang L, Zhang X (2023) Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1. Nat Commun 14(1):4373

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gnani D, Crippa S, Della Volpe L, Rossella V, Conti A, Lettera E, Rivis S, Ometti M, Fraschini G, Bernardo ME, Di Micco R (2019) An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program. Aging Cell 18(3):e12933

Article  PubMed  PubMed Central  Google Scholar 

Goldmann JM, Veltman JA, Gilissen C (2019) De novo mutations reflect development and aging of the human germline. Trends Genet 35(11):828–839

Article  CAS  PubMed  Google Scholar 

Gu C, Du W, Chai M, Jin Z, Zhou Y, Guo P, Zhou Y, Tan WS (2022) Human umbilical cord-derived mesenchymal stem cells affect urea synthesis and the cell apoptosis of human induced hepatocytes by secreting IL-6 in a serum-free co-culture system. Biotechnol J 17(1):e2100096

Article  PubMed  Google Scholar 

Hardy K, Mansfield L, Mackay A, Benvenuti S, Ismail S, Arora P, O’Hare MJ, Jat PS (2005) Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell 16(2):943–953

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassan-Nasab M, Dehghani-Ashkezari M, Montazeri F, Farashahi-Yazd E, Hajizadeh-Tafti F, Golzadeh J, Hoseini SM, Aflatoonian B (2024) Immunomodulatory potential of human testicular tissue-derived mesenchymal stem/stromal cells over the lifespan. Cell Tissue Biol 18:390–402

Herranz N, Gil J (2018) Mechanisms and functions of cellular senescence. J Clin Invest 128(4):1238–1246

Article  PubMed  PubMed Central  Google Scholar 

Hoseini S, Montazeri F, Kalantar S, Bahrami A, Zarein F, Moghadam Matin M (2020a) Mesenchymal stem cells: interactions with immune cells and immunosuppressive-immunomodulatory properties. Sci J Iran Blood Transfus Organ 17(2):147–169

Google Scholar 

Hoseini SM, Kalantar SM, Bahrami AR, Matin MM (2020b) Human amniocytes: a comprehensive study on morphology, frequency and growth properties of subpopulations from a single clone to the senescence. Cell Tissue Biol 14(2):102–112

Article  Google Scholar 

Hoseini SM, Montazeri F, Bahrami AR, Kalantar SM, Rahmani S, Zarein F, Matin MM (2020c) Investigating the expression of pluripotency-related genes in human amniotic fluid cells: a semi-quantitative comparison between different subpopulations, from primary to cultured amniocytes. Reprod Biol 20(3):338–347

Article  PubMed  Google Scholar 

Hoseini SM, Montazeri F, Moghaddam-Matin M, Bahrami AR, Meimandi HH, Ghasemi-Esmailabad S, Kalantar SM (2020d) Comparison of chromosomal instability of human amniocytes in primary and long-term cultures in AmnioMAX II and DMEM media: a cross-sectional study. Int J Reprod Biomed 18(10):885–898

PubMed  PubMed Central  Google Scholar 

Hoseini SM, Sheikhha MH, Kalantar SM, Matin MM, Aflatoonian B, Bahrami AR, Zarein F, Rahmani S, Montazeri F (2020e) A comparative analysis of immunomodulatory genes in two clonal subpopulations of CD90+ amniocytes isolated from human amniotic fluid. Placenta 101:234–241

Article  CAS  PubMed  Google Scholar 

Hoseini SM, Moghaddam-Matin M, Bahrami AR, Montazeri F, Kalantar SM (2021) Human amniotic fluid stem cells: general characteristics and potential therapeutic applications. J Shahid Sadoughi Univ Med Sci 28(12):3252–3275

Google Scholar 

Hoseini S, Hosseini E, Abessi P, Montazeri F (2024a) Paracrine secretions and immunological activities of human mesenchymal stem cells: the key regenerative factors of microenvironment. J Stem Cell Res Ther 14:1000636. https://doi.org/10.35248/2157-7633.24.14.636

Hoseini S, Kalantar S, Zarein F, Sadeghian F, Ghasemi-Esmailabad S, Hajimaghsoudi E, Montazeri F (2024b) Efficient isolation of mesenchymal stem cells from amniotic fluid via a two-step culture method. Biomed Res Therapy 11(8):6683–6697

Article  Google Scholar 

Iness AN, Felthousen J, Ananthapadmanabhan V, Sesay F, Saini S, Guiley KZ, Rubin SM, Dozmorov M, Litovchick L (2019) The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Oncogene 38(7):1080–1092

Article  CAS  PubMed  Google Scholar 

Ito T, Sawada R, Fujiwara Y, Seyama Y, Tsuchiya T (2007) FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2. Biochem Biophys Res Commun 359(1):108–114

Article  CAS  PubMed  Google Scholar 

Johung K, Goodwin EC, DiMaio D (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol 81(5):2102–2116

Article  CAS  PubMed 

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