Red deer ( L.) antler stem cell culture medium inhibits prostate cancer cells

Akinyemi AO, Simpson KE, Oyelere SF, Nur M, Ngule CM, Owoyemi BCD, Ayarick VA, Oyelami FF, Obaleye O, Esoe DP, Liu X, Li Z (2023) Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review. Mol Med 21:29–112

Google Scholar 

Al Salhi Y, Sequi MB, Valenzi FM, Fuschi A, Martoccia A, Suraci PP, Carbone A, Tema G, Lombardo R, Cicione A, Pastore AL, De Nunzio C (2023) Cancer stem cells and prostate cancer: a narrative review. Int J Mol Sci 24:24–7746

Article  Google Scholar 

Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326–336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W, Pasqualini R (2004) Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 6:275–284

Article  CAS  PubMed  Google Scholar 

Basu S, Tindall DJ (2010) Androgen action in prostate cancer. Horm Cancer 1:223–228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett HL, Fleming JT, O’Prey J, Ryan KM, Leung HY (2010) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis 1:e72

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernal A, Bechler AJ, Mohan K, Rizzino A, Mathew G (2004) The current therapeutic landscape for metastatic prostate cancer. Pharmaceuticals (Basel) 8:17–351

Google Scholar 

Booth A, Magnuson A, Fouts J, Foster M (2015) Adipose tissue, obesity and adipokines: role in cancer promotion. Horm Mol Biol Clin Investig 21:57–74

Article  CAS  PubMed  Google Scholar 

Boutin B, Tajeddine N, Vandersmissen P, Zanou N, Van Schoor M, Mondin L, Courtoy PJ, Tombal B, Gailly P (2013) Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis. Prostate 73:1090–1102

Article  CAS  PubMed  Google Scholar 

Cai H, Babic I, Wei X, Huang J, Witte ON (2011) Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Res 71:862–872

Article  CAS  PubMed  Google Scholar 

Cao XH, Chen X, Yang K, Wang YL, Liang MX, Fei YJ, Tang JH (2023) Vaspin accelerates the proliferation, invasion and metastasis of triple-negative breast cancer through MiR-33a-5p/ABHD2. Cancer Med 12:4530–4542

Article  CAS  PubMed  Google Scholar 

Chonco L, Landete-Castillejos T, Serrano-Heras G, Serrano MP, Pérez-Barbería FJ, González-Armesto C, García A, de Cabo C, Lorenzo JM, Li C, Segura T (2021) Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas. Sci Rep 8:11–42

Google Scholar 

Chu DT, Nguyen TT, Tien NLB, Tran DK, Jeong JH, Anh PG, Thanh VV, Truong DT, Dinh TC (2020) Recent progress of stem cell therapy in cancer treatment: molecular mechanisms and potential applications. Cells 28:9–563

Google Scholar 

Conrad F, Zhu X, Zhang X, Chalkley RJ, Burlingame AL, Marks JD, Liu B (2009) Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med (Berl) 87:507–514

Article  CAS  PubMed  Google Scholar 

Dong Z, Fu S, Xu X, Yang Y, Du L, Li W, Kan S, Li Z, Zhang X, Wang L, Li J, Liu H, Qu X, Wang C (2014) Leptin-mediated regulation of ICAM-1 is Rho/ROCK dependent and enhances gastric cancer cell migration. Br J Cancer 110:1801–1810

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feleke M, Bennett S, Chen J, Hu X, Williams D, Xu J (2021) New physiological insights into the phenomena of deer antler: a unique model for skeletal tissue regeneration. J Orthop Transl 27:57–66

Google Scholar 

Goss RJ (1970) Problems of antlerogenesis. Clin Orthop 69:227–238

CAS  PubMed  Google Scholar 

Goss RJ (1995) Future directions in antler research. Anat Rec 241:291–302

Article  CAS  PubMed  Google Scholar 

Jiang P, Du W, Wu M (2007) p53 and Bad: remote strangers become close friends. Cell Res 17:283–285

Article  CAS  PubMed  Google Scholar 

Kierdorf U, Kierdorf H (2011) Deer antlers—A model of mammalian appendage regeneration: An extensive review. Gerontology 57:53–65

Article  PubMed  Google Scholar 

Kierdorf U, Miller KV, Flohr S, Gomez S, Kierdorf H (2017) Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus). PLoS ONE. 12:e0173775

Article  PubMed  PubMed Central  Google Scholar 

Kim WK, Kwon Y, Jang M, Park M, Kim J, Cho S, Jang DG, Lee WB, Jung SH, Choi HJ, Min BS, Il Kim T, Hong SP, Paik YK, Kim H (2019) β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers. Sci Rep 5:9–18440

Google Scholar 

Kim JW, Kim JH, Lee YJ (2024) The role of adipokines in tumor progression and its association with obesity. Biomedicines 3:12–97

Google Scholar 

Korzekwa AJ, Kononiuk A, Kordan W, Orzołek A (2023) Retinoic acid alters metalloproteinase action in red deer antler stem cells. PLoS ONE 10(18):e0287782

Article  Google Scholar 

Kurowska P, Mlyczyńska E, Dawid M, Jurek M, Klimczyk D, Dupont J, Rak A (2021) Review: Vaspin (SERPINA12) expression and function in endocrine cells. Cells 6:10–1710

Google Scholar 

Landete-Castillejos T, Kierdorf H, Gomez S, Luna S, García AJ, Cappelli J, Pérez-Serrano M, Pérez-Barbería J, Gallego L, Kierdorf U (2019) Antlers - Evolution, development, structure, composition, and biomechanics of an outstanding type of bone. Bone 128:115046

Article  CAS  PubMed  Google Scholar 

Leung JK, Sadar MD (2017) Non-genomic actions of the androgen receptor in prostate cancer. Front Endocrinol (Lausanne) 17:8–2

Google Scholar 

Li J, Lee AS (2006) Stress induction of Grp78/BiP and its role in cancer. Curr Mol Med 6:45–54

Article  CAS  PubMed  Google Scholar 

Li C, Clark D, Lord E, Stanton J, Suttie J (2002) Sampling technique to discriminate the different tissue layers for gene discovery from the growing deer antler tip. Anat Rec 268:125–130

Article  CAS  PubMed  Google Scholar 

Li C, Yang F, Sheppard A (2009) Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers. Curr Stem Cell Res Ther 4:237–251

Article  CAS  PubMed  Google Scholar 

Li C, Zhao H, Liu Z, McMahon C (2014) Deer antler–A novel model for studying organ regeneration in mammals. Int J Biochem Cell Biol 56:111–122

Article  PubMed  Google Scholar 

Li C, Li Y, Wang W, Scimeca M, Melino G, Du R, Shi Y (2023) Deer antlers: the fastest growing tissue with least cancer occurrence. Cell Death Differ 30:2452–2461

Article  PubMed  PubMed Central  Google Scholar 

Liao RS, Ma S, Miao L, Li R, Yin Y, Raj GV (2013) Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation. Transl Androl Urol 2:187–196

PubMed  PubMed Central  Google Scholar 

Liu Q, Li J, Chang J, Guo Y, Wen D (2023) The characteristics and medical applications of antler stem cells. Stem Cell Res Ther 14:225

Article  PubMed  PubMed Central  Google Scholar 

Maitland NJ, Collins AT (2008) Prostate cancer stem cells: a new target for therapy. J Clin Oncol 26:2862–2870

Article  PubMed  Google Scholar 

McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R, Walker BR (2012) Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes 61:1072–1081

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif