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Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
Health Data Sciences and Cardiovascular Disease in Africa: Needs and the Way Forward
The rising burden of cardiovascular disease (CVD) in Africa is of great concern. Health data sciences is a rapidly develop...
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health Data Sciences and Cardiovascular Diseases in South Asia: Innovations and Challenges in Digital Health
Health data sciences can help mitigate high burden of cardiovascular disease (CVD) management in South Asia by increasing ...
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Do Statins Affect Cognitive Health? A Narrative Review and Critical Analysis of the Evidence
Statins are the first-line treatment for hypercholesterolemia and play a key role in the prevention of cardiovascular dise...
The Role of Iron in Atherosclerosis and its Association with Related Diseases
The Role of Iron in Atherosclerosis and its Association with Related Diseases
This review aims to elucidate the multifaceted role of iron in the pathogenesis of atherosclerosis. The primary objective ...
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Dyslipidemia is a casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more e...
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of ...
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
In this review, we discuss the importance of digital health equity and how social determinants of health (and intersection...
Lp(a): A Rapidly Evolving Therapeutic Landscape
Lp(a): A Rapidly Evolving Therapeutic Landscape
Elevated lipoprotein(a) (Lp[a]) is a genetically determined cardiovascular risk factor, causally linked to both atheroscle...
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
The purpose of this review is to evaluate the current state of knowledge regarding the technical challenges associated wit...
PCSK9 Monoclonal Antibodies Have Come a Long Way
PCSK9 Monoclonal Antibodies Have Come a Long Way
This review examines the pivotal role of monoclonal antibodies against PCSK9 in lipid-lowering therapy, emphasizing their ...
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic ant...
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological health encompasses a constellation of negative and positive factors—i.e., psychosocial stress, depress...
How Will Our Practice Change After the CLEAR Outcomes Trial?
How Will Our Practice Change After the CLEAR Outcomes Trial?
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-...
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of premature death. Lipid disorders, particularly elevat...
Lipoprotein(a): from Causality to Treatment
Lipoprotein(a): from Causality to Treatment
This paper reviews the evidence why lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disease and how high...
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular disease (CVD). This revie...
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Heart failure (HF) is one of the main causes of cardiovascular mortality in the western world. Despite great advances in t...
What Causes Premature Coronary Artery Disease?
What Causes Premature Coronary Artery Disease?
This review provides an overview of genetic and non-genetic causes of premature coronary artery disease (pCAD). pCAD refer...
Sex Differences in Cardiac Transplantation
Sex Differences in Cardiac Transplantation
The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT). ...
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
The UK National Health Service (NHS) has recently announced a Newborn Genomes Programme (NGP) to identify infants with tre...
HDL as a Treatment Target: Should We Abandon This Idea?
HDL as a Treatment Target: Should We Abandon This Idea?
High-density lipoproteins (HDL) have long been regarded as an antiatherogenic lipoprotein species by virtue of their role ...
Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease
Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease
Characterize the risk of cardiovascular disease (CVD) in individuals with polycystic ovarian syndrome (PCOS). Review the p...
Polysocial Risk Scores: Implications for Cardiovascular Disease Risk Assessment and Management
Polysocial Risk Scores: Implications for Cardiovascular Disease Risk Assessment and Management
To review current evidence, discuss key knowledge gaps and identify opportunities for development, validation and applicat...
Heart Failure Treatment in 2023: Is There a Place for Lipid Lowering Therapy?
Heart Failure Treatment in 2023: Is There a Place for Lipid Lowering Therapy?
An evidence for lipid lowering therapy in heart failure is briefly summarized in this review. Heart failure therapy is bas...
Gene Regulatory Networks in Coronary Artery Disease
Gene Regulatory Networks in Coronary Artery Disease
Coronary artery disease is a complex disorder and the leading cause of mortality worldwide. As technologies for the genera...
Caregiver Influences on Eating Behaviors in Children: An Opportunity for Preventing Obesity
Caregiver Influences on Eating Behaviors in Children: An Opportunity for Preventing Obesity
This review seeks to define caregiver practices that impact childhood eating behaviors and identify ways to utilize these ...
Natural Sirtuin1 Activators and Atherosclerosis: an Overview
Natural Sirtuin1 Activators and Atherosclerosis: an Overview
The purpose of this review is to summarize the most recent findings investigating the impact of several natural sirtuin (S...
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