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Endothelial transcriptomic, epigenomic and proteomic data challenge the proposed role for TSAd in vascular permeability
Endothelial transcriptomic, epigenomic and proteomic data challenge the proposed role for TSAd in vascular permeability
The vascular endothelial growth factor VEGF drives excessive vascular permeability to cause tissue-damaging oedema in neov...
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Microvascular and cerebrovascular alterations in Raynaud’s phenomenon and fibromyalgia
Consent for publication Written informed consent was obtain...
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis
Angiogenesis is a crucial component of various physiological and pathological processes, including embryonic development, ...
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Current standard of care is...
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in pre...
SDF-1α mRNA therapy in peripheral artery disease
SDF-1α mRNA therapy in peripheral artery disease
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases ...
Acute aortic dissection in a patient with Hereditary Hemorrhagic Telangiectasia associated with Juvenile Polyposis due to SMAD4 mutation: case report and literature review
Acute aortic dissection in a patient with Hereditary Hemorrhagic Telangiectasia associated with Juvenile Polyposis due to SMAD4 mutation: case report and literature review
We present a novel case of concurrent Hereditary Hemorrhagic Telangiectasia-Juvenile Polyposis Syndrome (HHT-JP), resultin...
Mixed lineage kinase (MLK) controls tumor development and angiogenesis
Mixed lineage kinase (MLK) controls tumor development and angiogenesis
Cancer is among the leading causes of death in the USA and worldwide. Solid tumors require the formation of new blood vess...
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-...
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and rep...
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system t...
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is ...
Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application
Diversity of extracellular vesicle sources in atherosclerosis: role and therapeutic application
Extracellular vesicles (EVs) are phospholipid bilayer membrane structures secreted by cells and widely present in blood or...
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient ou...
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethy...
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequat...
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cau...
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesi...
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when...
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinop...
Senescent endothelial cells: a potential target for diabetic retinopathy
Senescent endothelial cells: a potential target for diabetic retinopathy
Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Curr...
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metast...
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology
Snake venoms are intricate mixtures of enzymes and bioactive factors that induce a range of detrimental effects in afflict...
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Angiogenesis is limited by LIC1-mediated lysosomal trafficking
Dynein cytoplasmic 1 light intermediate chain 1 (LIC1, DYNC1LI1) is a core subunit of the dynein motor complex. The LIC1 s...
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by ...
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis
Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to defi...
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially r...
Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
In multiple neurodegenerative diseases, including age-related macular degeneration, retinitis pigmentosa, and macular tela...
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular g...
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