Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164–74.
PubMed PubMed Central Google Scholar
Patel M, Ramavataram DV. Non transferrin bound iron: nature, manifestations and analytical approaches for estimation. Indian J Clin Biochem. 2012;27(4):322–32.
Article PubMed PubMed Central CAS Google Scholar
Brissot P, Le Lan C, Troadec MB, et al. [HFE hemochromatosis: pathogenic and diagnostic approach]. Transfus Clin Biol. 2005;12(2):77–82.
Article PubMed CAS Google Scholar
de Valk B, Addicks MA, Gosriwatana I, Lu S, Hider RC, Marx JJ. Non-transferrin-bound iron is present in serum of hereditary haemochromatosis heterozygotes. Eur J Clin Invest. 2000;30(3):248–51.
Ward DM, Kaplan J. Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012;1823(9):1426–33.
Article PubMed PubMed Central CAS Google Scholar
Ravasi G, Pelucchi S, Russo A, Mariani R, Piperno A. Ferroportin disease: a novel SLC40A1 mutation. Dig Liver Dis. 2020;52(6):688–90.
Article PubMed CAS Google Scholar
Ravingerová T, Kindernay L, Barteková M, et al. The Molecular mechanisms of Iron Metabolism and its role in Cardiac Dysfunction and Cardioprotection. Int J Mol Sci. 2020;21(21):7889.
Article PubMed PubMed Central Google Scholar
Libby P. The changing landscape of atherosclerosis. Nature. 2021;592(7853):524–33.
Article PubMed CAS Google Scholar
Vinchi F, Porto G, Simmelbauer A, et al. Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. Eur Heart J. 2020;41(28):2681–95.
Article PubMed CAS Google Scholar
Yang Z, Shi J, Chen L, Fu C, Shi D, Qu H. Role of Pyroptosis and Ferroptosis in the progression of atherosclerotic plaques. Front Cell Dev Biol. 2022;10:811196.
Article PubMed PubMed Central Google Scholar
Hu X, Cai X, Ma R, Fu W, Zhang C, Du X. Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages. J Cell Physiol. 2019;234(10):18792–800.
Article PubMed CAS Google Scholar
Tang X, Zhang Z, Fang M, et al. Transferrin plays a central role in coagulation balance by interacting with clotting factors. Cell Res. 2020;30(2):119–32.
Article PubMed CAS Google Scholar
Kautz L, Gabayan V, Wang X, et al. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013;5(5):1436–42.
Article PubMed CAS Google Scholar
Kirk EA, Heinecke JW, LeBoeuf RC. Iron overload diminishes atherosclerosis in apoe-deficient mice. J Clin Invest. 2001;107(12):1545–53.
Article PubMed PubMed Central CAS Google Scholar
Demetz E, Tymoszuk P, Hilbe R, et al. The haemochromatosis gene hfe and kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020;41(40):3949–59.
Article PubMed CAS Google Scholar
Marques VB, Leal M, Mageski J, et al. Chronic iron overload intensifies atherosclerosis in apolipoprotein E deficient mice: role of oxidative stress and endothelial dysfunction. Life Sci. 2019;233:116702.
Vinchi F. Non-transferrin-bound Iron in the spotlight: Novel mechanistic insights into the vasculotoxic and atherosclerotic effect of Iron. Antioxid Redox Signal. 2021;35(6):387–414.
Article PubMed PubMed Central CAS Google Scholar
Xiao FJ, Zhang D, Wu Y, et al. miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis. Biochem Biophys Res Commun. 2019;515(3):448–54.
Article PubMed CAS Google Scholar
Bai T, Li M, Liu Y, Qiao Z, Wang Z. Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell. Free Radic Biol Med. 2020;160:92–102.
Article PubMed CAS Google Scholar
Wang D, Ye P, Kong C, et al. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis. Exp Cell Res. 2021;402(1):112552.
Article PubMed CAS Google Scholar
Li L, Wang H, Zhang J, Chen X, Zhang Z, Li Q. Effect of endothelial progenitor cell-derived extracellular vesicles on endothelial cell ferroptosis and atherosclerotic vascular endothelial injury. Cell Death Discov. 2021;7(1):235.
Article PubMed PubMed Central CAS Google Scholar
Zhao X, Tan F, Cao X, et al. PKM2-dependent glycolysis promotes the proliferation and migration of vascular smooth muscle cells during atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2020;52(1):9–17.
Article PubMed CAS Google Scholar
Kawada S, Nagasawa Y, Kawabe M, et al. Iron-induced calcification in human aortic vascular smooth muscle cells through interleukin-24 (IL-24), with/without TNF-alpha. Sci Rep. 2018;8(1):658.
Article PubMed PubMed Central Google Scholar
Ye Y, Chen A, Li L, et al. Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int. 2022;102(6):1259–75.
Article PubMed CAS Google Scholar
Xu S. Iron and atherosclerosis: the Link Revisited. Trends Mol Med. 2019;25(8):659–61.
Article PubMed CAS Google Scholar
Zhang S, Bei Y, Huang Y, et al. Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice. Mol Med. 2022;28(1):121.
Article PubMed PubMed Central CAS Google Scholar
Mathew OP, Ranganna K, Milton SG. Involvement of the antioxidant effect and anti-inflammatory response in butyrate-inhibited vascular smooth muscle cell proliferation. Pharmaceuticals (Basel). 2014;7(11):1008–27.
Article PubMed CAS Google Scholar
Haschka D, Hoffmann A, Weiss G. Iron in immune cell function and host defense. Semin Cell Dev Biol. 2021;115:27–36.
Article PubMed CAS Google Scholar
Cai J, Zhang M, Liu Y, et al. Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis. Cell Biosci. 2020;10(1):137.
Article PubMed PubMed Central CAS Google Scholar
Saeed O, Otsuka F, Polavarapu R, et al. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32(2):299–307.
Article PubMed CAS Google Scholar
Cornelissen A, Guo L, Sakamoto A, Virmani R, Finn AV. New insights into the role of iron in inflammation and atherosclerosis. EBioMedicine. 2019;47:598–606.
Comments (0)