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E3 Ubiquitin Ligase FBXO32 Promotes LPS-Induced Cardiac Injury by Regulating ANXA1/PI3K/AKT Signaling
E3 Ubiquitin Ligase FBXO32 Promotes LPS-Induced Cardiac Injury by Regulating ANXA1/PI3K/AKT Signaling
Sepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis. Therefore, understanding SIC pathogenesis and deve...
Isoorientin Ameliorates Macrophage Pyroptosis and Atherogenesis by Reducing KDM4A Levels and Promoting SKP1-Cullin1-F-box E3 Ligase-mediated NLRP3 Ubiquitination
Isoorientin Ameliorates Macrophage Pyroptosis and Atherogenesis by Reducing KDM4A Levels and Promoting SKP1-Cullin1-F-box E3 Ligase-mediated NLRP3 Ubiquitination
Isoorientin (ISO) is a flavonoid compound with potential antioxidant and antiatherosclerotic properties. This investigatio...
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson’s Disease
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson’s Disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by the pro...
CRISPR/Cas9-Mediated Knockout and Overexpression Studies Unveil the Role of PD-L1 in Immune Modulation in a Psoriasis-like Mouse Model
CRISPR/Cas9-Mediated Knockout and Overexpression Studies Unveil the Role of PD-L1 in Immune Modulation in a Psoriasis-like Mouse Model
The role of programmed death-ligand 1 (PD-L1), an essential immune checkpoint protein, has garnered considerable interest ...
The Inflammatory Axis of /NRG1 in the Differential Diagnosis and Prognosis of Multiple Sclerosis and Neuromyelitis Optica
The Inflammatory Axis of /NRG1 in the Differential Diagnosis and Prognosis of Multiple Sclerosis and Neuromyelitis Optica
Multiple sclerosis (MS) and Neuromyelitis Optica (NMO) are immune-related CNS inflammatory diseases that often present wit...
MLKL–Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage
MLKL–Mediated Necroptosis Predominantly Contributes to Immune-Associated Myocardial Damage
Activated T cells and macrophages play a critical role in immune-associated myocarditis. However, the molecular and cellul...
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation
Sirtuin-6 (SIRT6) has a pivotal role in a wide array of cellular biological functions and is linked to the progression of ...
Effects of Troxerutin on Oxidative Stress, Inflammation and Galectin- 3 Expression in Intracerebroventricular Kainic Acid-Induced Neurotoxicity
Effects of Troxerutin on Oxidative Stress, Inflammation and Galectin- 3 Expression in Intracerebroventricular Kainic Acid-Induced Neurotoxicity
Excitotoxicity caused by excessive concentration of the excitatory neurotransmitter glutamate causes neuronal cell death a...
PTGS2 Silencing Inhibits Ferroptosis in -induced Osteomyelitis By Blocking the IL-17A Signaling Pathway
PTGS2 Silencing Inhibits Ferroptosis in -induced Osteomyelitis By Blocking the IL-17A Signaling Pathway
Osteomyelitis caused by Staphylococcus aureus (S. aureus) infection is an inflammatory bone disease characterized by conti...
TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia–Reperfusion Injury
TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia–Reperfusion Injury
Intestinal Ischemia–Reperfusion (IIR) injury is a common clinical pathophysiological condition, ye...
CLICs Inhibitor IAA94 Alleviates Inflammation and Injury in Septic Liver by Preventing Pyroptosis in Macrophages
CLICs Inhibitor IAA94 Alleviates Inflammation and Injury in Septic Liver by Preventing Pyroptosis in Macrophages
Macrophage pyroptosis represents a pivotal mechanism underlying acute liver injury during sepsis. Chloride intracellular c...
Proteomic Profiles of Neutrophils from Behcet’s Uveitis Patients and their Sex Differences
Proteomic Profiles of Neutrophils from Behcet’s Uveitis Patients and their Sex Differences
Behcet's uveitis (BU) is one of the most vision-threatening uveitis entities with male-biased incidence and severity. ...
4,4′-Dimethoxychalcone Mitigates Neuroinflammation Following Traumatic Brain Injury Through Modulation of the TREM2/PI3K/AKT/NF-κB Signaling Pathway
4,4′-Dimethoxychalcone Mitigates Neuroinflammation Following Traumatic Brain Injury Through Modulation of the TREM2/PI3K/AKT/NF-κB Signaling Pathway
Research on 4,4’-dimethoxychalcone (DMC) in the context of traumatic brain injury (TBI) is extremely limited, and no...
Inhibition of Macrophage Activation by Minocycline Attenuates CCI-Induced Neuropathic Pain
Inhibition of Macrophage Activation by Minocycline Attenuates CCI-Induced Neuropathic Pain
Neuropathic pain is characterized by a high prevalence and associated with a variety of disorders of the peripheral and ce...
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
Sepsis is a severe systemic inflammatory syndrome and one of the leading causes of global morbidity and mortality. Preclin...
Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease
Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease
There is increasing interest in developing therapeutic interventions aimed at preventing neuroinflammation in Parkinson...
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Neuron–microglia communication through the fractalkine pathway is a critical factor mediating microglial proliferati...
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
Sepsis-induced acute lung injury (ALI) is a life-threatening condition with high mortality rates, and its underlying mecha...
Identification of Key Genes Related to Immune-Lipid Metabolism in Skin Barrier Damage and Analysis of Immune Infiltration
Identification of Key Genes Related to Immune-Lipid Metabolism in Skin Barrier Damage and Analysis of Immune Infiltration
Several physical and chemical factors regulate skin barrier function. Skin barrier dysfunction causes many inflammatory sk...
Characterizing Non-T2 Asthma: Key Pathways and Molecular Implications Indicative of Attenuated Th2 Response
Characterizing Non-T2 Asthma: Key Pathways and Molecular Implications Indicative of Attenuated Th2 Response
Non-Type 2 (non-T2) asthma is characterized by a lack of allergic sensitization and normal to low total IgE levels. We aim...
Pharmacological Inhibition of Phosphoglycerate Kinase 1 Reduces OxiDative Stress and Restores Impaired Autophagy in Experimental Acute Pancreatitis
Pharmacological Inhibition of Phosphoglycerate Kinase 1 Reduces OxiDative Stress and Restores Impaired Autophagy in Experimental Acute Pancreatitis
Damage to pancreatic acinar cells (PAC) and intracellular metabolic disturbances play crucial roles in pancreatic necrosis...
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI
Traumatic brain injury (TBI) is a severe injury characterized by neuroinflammation and oxidative stress. NAMO (Nicotinamid...
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis
The underlying causes of age-related macular degeneration (AMD) remain elusive and treatment options of it are limited, wh...
Acetyl 11-Keto Beta-Boswellic Acid Improves Neurological Functions in a Mouse Model of Multiple Sclerosis
Acetyl 11-Keto Beta-Boswellic Acid Improves Neurological Functions in a Mouse Model of Multiple Sclerosis
Acetyl-11-keto-β-boswellic acid is one of the main active components of Boswellia sp. resin with the most potent anti...
Multiple Machine Learning Identifies Key Gene PHLDA1 Suppressing NAFLD Progression
Multiple Machine Learning Identifies Key Gene PHLDA1 Suppressing NAFLD Progression
Non-alcoholic fatty liver disease (NAFLD) poses a serious global health threat, with its progression mechanisms not yet fu...
GZMK Facilitates Experimental Rheumatoid Arthritis Progression by Interacting with CCL5 and Activating the ERK Signaling
GZMK Facilitates Experimental Rheumatoid Arthritis Progression by Interacting with CCL5 and Activating the ERK Signaling
Synovial over-proliferation is a key event in the progression of rheumatoid arthritis (RA) disease. Ferroptosis may be ess...
Complement Molecule C3a Exacerbates Early Brain Injury After Subarachnoid Hemorrhage by Inducing Neuroinflammation Through the C3aR-ERK-P2X7-NLRP3 Inflammasome Signaling Axis
Complement Molecule C3a Exacerbates Early Brain Injury After Subarachnoid Hemorrhage by Inducing Neuroinflammation Through the C3aR-ERK-P2X7-NLRP3 Inflammasome Signaling Axis
An important aspect of the pathophysiology of early brain damage (EBI) after subarachnoid hemorrhage (SAH) is inflammasome...
Identification of a 5-Plex Cytokine Signature that Differentiates Patients with Multiple Systemic Inflammatory Diseases
Identification of a 5-Plex Cytokine Signature that Differentiates Patients with Multiple Systemic Inflammatory Diseases
Patients with non-infectious systemic inflammation may suffer from one of many diseases, including hyperinflammation (HI),...
Kaempferol Remodels Liver Monocyte Populations and Treats Hepatic Fibrosis in Mice by Modulating Intestinal Flora and Metabolic Reprogramming
Kaempferol Remodels Liver Monocyte Populations and Treats Hepatic Fibrosis in Mice by Modulating Intestinal Flora and Metabolic Reprogramming
Changes in gut flora are associated with liver fibrosis. The interactions of host with intestinal flora are still unknown,...
Pristimerin Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier Function, Gut Microbiota Balance and Host Metabolism
Pristimerin Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier Function, Gut Microbiota Balance and Host Metabolism
Pristimerin is a pentacyclic triterpenoid mainly derived from Celastraceae plants such as Maytenus ilicifolia, which has b...
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