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Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alteratio...
PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer
PRKN-mediated the ubiquitination of IQGAP3 regulates cell growth, metastasis and ferroptosis in early-onset colorectal cancer
High IQ motif-containing GTPase activating protein 3 (IQGAP3) expression is considered to be associated with poor prognosi...
N-methyladenosine (mA) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N-methyladenosine (mA) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
Modifications of the respiratory chain of as an alkalophilic and cyanide-degrading microorganism
Modifications of the respiratory chain of as an alkalophilic and cyanide-degrading microorganism
Bacillus licheniformis can use cyanide as a nitrogen source for its growth. However, it can also carry out aerobic respira...
LncRNA UCA1 enhances NRF2 expression through the mA pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
LncRNA UCA1 enhances NRF2 expression through the mA pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
To explore the regulatory mechanism of lncRNA UCA1 and NRF2 in cardiomyocyte aging. In this study, we explored how lncRNA ...
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Oxidative stress-induced lens epithelial cells (LECs) death plays a pivotal role in pathogenesis of age-related cataract (...
Acute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
Acute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
The main therapeutic strategy for the treatment of patients with toxic liver failure is the elimination of the toxic agent...
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Cholestasis caused by impaired bile secretion in the liver is associated with the accumulation of primary bile acids (BA):...
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
To investigate the role of silent information regulator 6 (SIRT6) in regulating podocyte injury in diabetic nephropathy (D...
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Fibrillation of the amyloid beta (Aβ) peptide has often been associated with neurodegenerative pathologies such as Al...
Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria
Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria
Lithium is used in the long-term treatment of bipolar disorder, exhibiting a beneficial effect on the neuronal cells. The ...
Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts
Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts
Glutamine is well recognized as critical to the growth of most cell types. Within mitochondria glutamine is converted to g...
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells
Background: Cataracts are a significant cause of vision loss, adversely affecting the quality of human life. Numerous stud...
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Accumulating studies have unraveled that dexmedetomidine (DEX) is neuroprotective against brain damage. However, it remain...
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Acute lung injury characterized by overactive pulmonary inflammation is a common and serious complication of sepsis. Esome...
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Hypoxia has been reported to induce high expression of HIF-1α in multiple cancer tissues, and HIF-1α significant...
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associat...
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
Cysteine desulfurase (NFS1) is highly expressed in a variety of tumors, which is closely related to ferroptosis of tumor c...
METTL14 inhibits Aβ1-42-induced neuronal injury through regulating the stability of CBLN4 mRNA in Alzheimer’s disease
METTL14 inhibits Aβ1-42-induced neuronal injury through regulating the stability of CBLN4 mRNA in Alzheimer’s disease
Previous studies have suggested that N6-methyladenosine (mA) modification of RNA affects fundamental aspects of RNA metabo...
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells
Epigenetic mechanism of SET7/9-mediated histone methylation modification in high glucose-induced ferroptosis in retinal pigment epithelial cells
Ferroptosis of the retinal pigment epithelial (RPE) cells leads to retinal neuron injury and even visual loss. Our study a...
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
Natural products are a great resource for physiologically active substances. It is widely recognized that a major percenta...
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The current study explored melatonin (MEL) and its receptors, including MEL type 1 receptor (MT1) receptor and MEL type 2 ...
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Miltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various ty...
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes ...
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by auto...
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an on...
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the...
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Downregulation of circ_0044226 has been demonstrated to reduce pulmonary fibrosis, but the role of circ_0044226 in liver f...
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
Background: Diabetic retinopathy is one of the complications of diabetes mellitus. The aim of this study was to explore th...
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