Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity

Arosio P, Knowles TPJ, Linse S (2015) On the lag phase in amyloid fibril formation. Phys Chem Chem Phys 17:7606–7618

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee S, Hashemi M, Zagorski K, Lyubchenko YL (2021) Cholesterol in Membranes Facilitates Aggregation of Amyloid β Protein at Physiologically Relevant Concentrations. ACS Chem Neurosci 12:506–516. https://doi.org/10.1021/acschemneuro.0c00688

Article  CAS  PubMed  Google Scholar 

Banerjee S, Hashemi M, Zagorski K, Lyubchenko YL (2020) Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers. Int J Mol Sci 21. https://doi.org/10.3390/ijms21031129

Bucciantini M, Rigacci S, Stefani M (2014) Amyloid Aggregation: Role of Biological Membranes and the Aggregate-Membrane System. J Phys Chem Lett 5:517–527. https://doi.org/10.1021/jz4024354

Article  CAS  PubMed  Google Scholar 

Chen G, Xu T, Yan Y et al (2017) Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin 38:1205–1235. https://doi.org/10.1038/aps.2017.28

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen G, Xu T, Yan Y et al (2017) Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin 38:1205–1235. https://doi.org/10.1038/aps.2017.28

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen SIA, Linse S, Luheshi LM et al (2013) Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proc Natl Acad Sci 110:9758–9763. https://doi.org/10.1073/pnas.1218402110

Article  PubMed  PubMed Central  Google Scholar 

Esch FS, Keim PS, Beattie EC et al (1990) Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor. Science (1979) 248:1122–1124. https://doi.org/10.1126/science.2111583

Article  CAS  Google Scholar 

Fitzner D, Bader JM, Penkert H et al (2020) Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Rep 32:108132. https://doi.org/10.1016/j.celrep.2020.108132

Article  CAS  PubMed  Google Scholar 

Flagmeier P, De S, Michaels TCT et al (2020) Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation. Nat Struct Mol Biol 27:886–891. https://doi.org/10.1038/s41594-020-0471-z

Article  CAS  PubMed  Google Scholar 

Glabe CG, Kayed R (2006) Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology 66:S74–S78. https://doi.org/10.1212/01.wnl.0000192103.24796.42

Article  CAS  PubMed  Google Scholar 

Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid β-peptide. Nat Rev Mol Cell Biol 8:101–112. https://doi.org/10.1038/nrm2101

Article  CAS  PubMed  Google Scholar 

Habchi J, Chia S, Galvagnion C et al (2018) Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nat Chem 10:673–683. https://doi.org/10.1038/s41557-018-0031-x

Article  CAS  PubMed  Google Scholar 

Hampel H, Hardy J, Blennow K et al (2021) The Amyloid-β Pathway in Alzheimer’s Disease. Mol Psychiatry 26:5481–5503. https://doi.org/10.1038/s41380-021-01249-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardy JA, Higgins GA (1992) Alzheimer’s Disease: The Amyloid Cascade Hypothesis. Science (1979) 256:184–185. https://doi.org/10.1126/science.1566067

Article  CAS  Google Scholar 

Koo EH, Lansbury PT, Kelly JW (1999) Amyloid diseases: Abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci 96:9989–9990. https://doi.org/10.1073/pnas.96.18.9989

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krausser J, Knowles TPJ, Šarić A (2020) Physical mechanisms of amyloid nucleation on fluid membranes. Proc Natl Acad Sci 117:33090–33098. https://doi.org/10.1073/pnas.2007694117

Article  CAS  PubMed  PubMed Central  Google Scholar 

LeVine H (1995) Thioflavine T interaction with amyloid β-sheet structures. Amyloid 2:1–6. https://doi.org/10.3109/13506129509031881

Article  CAS  Google Scholar 

Matsuzaki K (2014) How Do Membranes Initiate Alzheimer’s Disease? Formation of Toxic Amyloid Fibrils by the Amyloid β-Protein on Ganglioside Clusters. Acc Chem Res 47:2397–2404. https://doi.org/10.1021/ar500127z

Article  CAS  PubMed  Google Scholar 

Meyer HW, Bunjes H, Ulrich AS (1999) Morphological transitions of brain sphingomyelin are determined by the hydration protocol: ripples re-arrange in plane, and sponge-like networks disintegrate into small vesicles. Chem Phys Lipids 99:111–123. https://doi.org/10.1016/S0009-3084(99)00029-8

Article  CAS  PubMed  Google Scholar 

Naiki H, Higuchi K, Hosokawa M, Takeda T (1989) Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T. Anal Biochem 177:244–249. https://doi.org/10.1016/0003-2697(89)90046-8

Article  CAS  PubMed  Google Scholar 

Nunan J, Small DH (2000) Regulation of APP cleavage by α-, β- and γ-secretases. FEBS Lett 483:6–10. https://doi.org/10.1016/S0014-5793(00)02076-7

Article  CAS  PubMed  Google Scholar 

Nyholm TKM, Lindroos D, Westerlund B, Slotte JP (2011) Construction of a DOPC/PSM/Cholesterol Phase Diagram Based on the Fluorescence Properties of trans-Parinaric Acid. Langmuir 27:8339–8350. https://doi.org/10.1021/la201427w

Article  CAS  PubMed  Google Scholar 

Parasassi T, De Stasio G, d’Ubaldo A, Gratton E (1990) Phase fluctuation in phospholipid membranes revealed by Laurdan fluorescence. Biophys J 57:1179–1186. https://doi.org/10.1016/S0006-3495(90)82637-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parasassi T, De Stasio G, Ravagnan G et al (1991) Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence. Biophys J 60:179–189. https://doi.org/10.1016/S0006-3495(91)82041-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parasassi T, Krasnowska EK, Bagatolli L, Gratton E (1998) Laurdan and Prodan as Polarity-Sensitive Fluorescent Membrane Probes. J Fluoresc 8:365–373. https://doi.org/10.1023/A:1020528716621

Article  CAS  Google Scholar 

Samsonov AV, Mihalyov I, Cohen FS (2001) Characterization of Cholesterol-Sphingomyelin Domains and Their Dynamics in Bilayer Membranes. Biophys J 81:1486–1500. https://doi.org/10.1016/S0006-3495(01)75803-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasahara K, Morigaki K, Shinya K (2013) Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure. Phys Chem Chem Phys 15:8929–8939

Article  CAS  PubMed  Google Scholar 

Schmit JD, Ghosh K, Dill K (2011) What drives amyloid molecules to assemble into oligomers and fibrils? Biophys J 100:450–458

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif