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Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations
Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations
Effective subunit vaccine development requires selecting appropriate adjuvant formulations to trigger desired adaptive imm...
AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA
AbOmpA in Acinetobacter baumannii: exploring virulence mechanisms of outer membrane-integrated and outer membrane vesicle-associated AbOmpA and developing anti-infective agents targeting AbOmpA
Acinetobacter baumannii is notorious for its antimicrobial resistance and its potential to cause epidemics in hospital set...
USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression
USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression
Ubiquitin-specific peptidase 24 (USP24), a deubiquitinating enzyme, regulates protein stability by removing ubiquitin. Thi...
Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185
Probiotics ameliorate H. pylori-associated gastric β-catenin and COX-2 carcinogenesis signaling by regulating miR-185
This study aimed to investigate whether probiotics can ameliorate the H. pylori-induced Wnt/β-catenin-related COX-2 c...
Involvement of nucleic acid-sensing toll-like receptors in human diseases and their controlling mechanisms
Involvement of nucleic acid-sensing toll-like receptors in human diseases and their controlling mechanisms
The innate immune system is the host’s initial response to eliminate pathogens and repair tissue damage. Innate immu...
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
CD81-guided heterologous EVs present heterogeneous interactions with breast cancer cells
Extracellular vesicles (EVs) are cell-secreted particles conceived as natural vehicles for intercellular communication. Th...
Exploring paraptosis as a therapeutic approach in cancer treatment
Exploring paraptosis as a therapeutic approach in cancer treatment
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis,&nb...
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
The molecular consequences of FOXF1 missense mutations associated with alveolar capillary dysplasia with misalignment of pulmonary veins
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a fatal congenital lung disorder strongly a...
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages
Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dent...
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease
Neurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are common complic...
EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
Betulinic acid (BA) has been well investigated for its antiproliferative and mitochondrial pathway-mediated apoptosis-indu...
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Beyond glycan barriers: non-cognate ligands and protein mimicry approaches to elicit broadly neutralizing antibodies for HIV-1
Human immunodeficiency virus type 1 (HIV-1) vaccine immunogens capable of inducing broadly neutralizing antibodies (bNAbs)...
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Intracellular sensing of lipopolysaccharide (LPS) is essential for the immune response against gram-negative bacteria and ...
Machine learning enabled classification of lung cancer cell lines co-cultured with fibroblasts with lightweight convolutional neural network for initial diagnosis
Machine learning enabled classification of lung cancer cell lines co-cultured with fibroblasts with lightweight convolutional neural network for initial diagnosis
Identification of lung cancer subtypes is critical for successful treatment in patients, especially those in advanced stag...
Extracellular vesicle therapy in neurological disorders
Extracellular vesicle therapy in neurological disorders
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in...
Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis
Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis
Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is li...
Dengue virus pathogenesis and host molecular machineries
Dengue virus pathogenesis and host molecular machineries
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent ...
Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
Myocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia ca...
T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable dis...
Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis
Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis
Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This ...
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently m...
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis...
Butterflies in the gut: the interplay between intestinal microbiota and stress
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk ...
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in dange...
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remain...
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological m...
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles exten...
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (S...
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (m...
Extracellular release in the quality control of the mammalian mitochondria
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mit...
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