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Efficacy and mechanism of inhibition of the GPR30-PI3K pathway by 4-phenylbutyric acid in the treatment of intrahepatic cholestasis of pregnancy
Efficacy and mechanism of inhibition of the GPR30-PI3K pathway by 4-phenylbutyric acid in the treatment of intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a liver disease that manifests predominantly in the later stages of pregnan...
Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue
Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue
Mechanistic studies have been suggested that adverse effect of bleomycin is attributed to formation of free radicals, mito...
Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights
Combined skin injury model from airblast overpressure and seawater immersion in rats: establishment, characterization, and mechanistic insights
In maritime operations, individuals often face the threat of combined injury caused by airblast overpressure and seawater ...
Exogenous mitochondria added on benefits for cellular prion protein overexpression in adipose-derived mesenchymal stem cells treatment on intracranial hemorrhage rat
Exogenous mitochondria added on benefits for cellular prion protein overexpression in adipose-derived mesenchymal stem cells treatment on intracranial hemorrhage rat
We examined whether combined exogenous mitochondria (ExMito) and cellular prion protein overexpression (Ove-PrPC) in adipo...
Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2–STAT3 pathway
Ciliary neurotrophic factor (CNTF) contributes to pelvic organ prolapse by modulating collagen expression via the JAK2–STAT3 pathway
Pelvic organ prolapse (POP) is a prevalent condition that affects postmenopausal women and significantly impacts their qua...
Nell-1 inhibits lipopolysaccharide-activated macrophages into M1 phenotype through the modulation of NF-κB pathway
Nell-1 inhibits lipopolysaccharide-activated macrophages into M1 phenotype through the modulation of NF-κB pathway
Nel-like molecule-1 (Nell-1), as a novel osteo-inductive molecule with great potential for clinical applications, has vari...
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation
Curcumin protects rat endplate chondrocytes against IL-1β-induced apoptosis via Bcl-2/Bax regulation
The study aims to investigate the protective effect of curcumin on intervertebral disc degeneration by examining its influ...
Protective effects of -acetylcysteine against titanium dioxide nanoparticles-induced kidney damage in rats
Protective effects of -acetylcysteine against titanium dioxide nanoparticles-induced kidney damage in rats
The objective of this study was to evaluate the potential protective effect of N-acetylcysteine (NAC) against kidney damag...
Serum proteomic profiling reveals potential predictive indicators for coronary artery calcification in stable ischemic heart disease
Serum proteomic profiling reveals potential predictive indicators for coronary artery calcification in stable ischemic heart disease
Coronary artery calcification (CAC) is a common complication in patients with stable ischemic heart disease (SIHD). Howeve...
Notch 2 from bone marrow mesenchymal stem cells alleviates smoke inhalation-induced lung injury by mediating alveolar cell differentiation
Notch 2 from bone marrow mesenchymal stem cells alleviates smoke inhalation-induced lung injury by mediating alveolar cell differentiation
Smoke inhalation-induced lung injury (SILI) is the major fatality in fire- and blast-related accidents. Bone marrow mesenc...
Direct exposure with exogenous mitochondria reduce colistin-induced mitochondrial dysfunction and cellular damages in isolated rat renal proximal tubular cells
Direct exposure with exogenous mitochondria reduce colistin-induced mitochondrial dysfunction and cellular damages in isolated rat renal proximal tubular cells
Kidney damage caused by colistin (polymyxin E) can bring about a decrease in creatinine clearance, potential proteinuria, ...
Taraxasterol attenuates inflammatory responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model via inactivation of the MAPK and NF-κB pathways
Taraxasterol attenuates inflammatory responses in a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model via inactivation of the MAPK and NF-κB pathways
Atopic dermatitis (AD) is an inflammatory skin disease. Taraxasterol has anti-inflammatory effects in various pathological...
miR-378d suppresses gastric cancer metastasis by targeting METTL4 to inhibit epithelial-mesenchymal transition
miR-378d suppresses gastric cancer metastasis by targeting METTL4 to inhibit epithelial-mesenchymal transition
Metastasis is a major determinant of prognosis in gastric cancer (GC), and microRNAs (miRNAs) play crucial roles in drivin...
In vivo and analysis of anti inflammatory, antipyretic and analgesic activity of methanolic extract of
In vivo and analysis of anti inflammatory, antipyretic and analgesic activity of methanolic extract of
Nigella Sativa (N. sativa) belongs to the family of Ranunculaceae and is an annual herb which is also known as black cumin...
Electron microscopic analysis of pomegranate and black chokeberry effects on acute pancreatitis in rats
Electron microscopic analysis of pomegranate and black chokeberry effects on acute pancreatitis in rats
Despite numerous experimental and clinical studies in terms of novel therapeutic strategies, the treatment of acute pancre...
Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease
Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is a common neurological disorder primarily affecting older adults. A hallmark of this cond...
Localization and function of APC15 during mouse oocyte meiotic progression
Localization and function of APC15 during mouse oocyte meiotic progression
The Anaphase-Promoting Complex/Cyclosome (APC/C) is a critical regulator of cell cycle progression, with APC15 serving as ...
RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway
RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway
Cervical cancer (CC) remains a leading cause of cancer mortality amongst females worldwide. Some of the CC patients may ex...
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
Corosolic acid (CA) is a well-known natural pentacyclic triterpene found in numerous therapeutic plants that can exhibit m...
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Adriamycin is a cytotoxic anthracycline antibiotic used to treat a wide variety of cancers. This study was made to detect ...
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
We analyzed the toxic effect of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in the...
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
The aim of this study was to explore the mechanism of bone marrow stem cells (BMSCs) sheets constructed with different dos...
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Wounds are the common fates in various microbial infections and physical damages including accidents, surgery, and burns. ...
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Insufficient evidence regarding how maternal undernutrition affects craniofacial bone development persists. With its uniqu...
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
SARS-CoV-2 infection is considered as a multi-organ disease, and several studies highlighted the relevance of the virus in...
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Immune checkpoint blockade therapy has demonstrated significant therapeutic effects in certain types of cancers. However, ...
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths and the fifth most common cancer worldw...
TUG1 exacerbates cerebral ischemia-reperfusion injury through miR-340-5p-mediated PTEN
TUG1 exacerbates cerebral ischemia-reperfusion injury through miR-340-5p-mediated PTEN
Long non-coding RNAs (LncRNAs) play a substantial role in the process of cerebral ischemia-reperfusion injury (CIRI). The ...
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
This study tested the hypothesis that empagliflozin (EMPA) therapy effectively protected renal and heart functions via dow...
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
There is an increased prevalence of cancer, and chemotherapy is widely and routinely utilized to manage the majority of ca...
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