Appel K, Meiser P, Millán E, Collado JA, Rose T, Gras CC, Carle R, Muñoz E (2015) Chokeberry (Aronia melanocarpa (Michx.) Elliot) concentrate inhibits NF-κB and synergizes with selenium to inhibit the release of pro-inflammatory mediators in macrophages. Fitoterapia 105:73–82. https://doi.org/10.1016/j.fitote.2015.06.009

Article  CAS  PubMed  Google Scholar 

Bhatia M (2005) Inflammatory response on the pancreatic acinar cell injury. Scand J Surg 94(2):97–102. https://doi.org/10.1177/145749690509400203

Article  CAS  PubMed  Google Scholar 

Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E et al (2018) Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models. Gastroenterology 154:689–703. https://doi.org/10.1053/j.gastro.2017.10.012

Article  CAS  PubMed  Google Scholar 

Borowska S, Brzóska MM (2016) Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics. Compr Rev Food Sci Food Saf 15(6):982–1017. https://doi.org/10.1111/1541-4337.12221

Article  CAS  PubMed  Google Scholar 

Bräunlich M, Slimestad R, Wangensteen H, Brede C, Malterud KE, Barsett H (2013) Extracts, anthocyanins and procyanidins from Aronia melanocarpa as radical scavengers and enzyme inhibitors. Nutrients 5(3):663–678. https://doi.org/10.3390/nu5030663. (PMID: 23459328)

Article  PubMed  PubMed Central  Google Scholar 

Coşkun T, Korkusuz P, Kaya Y, Örs Ü, Aker Y, Kilinç K (2003) Free oxygen radical-induced acute pancreatitis. A light and electron microscopic study. Hepatogastroenterology 50:43–48

PubMed  Google Scholar 

Denev PN, Kratchanov CG, Ciz M, Lojek A, Kratchanova MG (2012) Bioavailability and antioxidant activity of black chokeberry (Aronia melanocarpa) polyphenols: in vitro and in vivo evidences and possible mechanisms of action: a review. Comprehensive Reviews in Food Science and Food Safety 11(5):471–489

Article  CAS  Google Scholar 

Elfalleh W, Tlili N, Nasri N, Yahia Y, Hannachi H, Chaira N, Ying M, Ferchichi A (2011) Antioxidant capacities of phenolic compounds and tocopherols from Tunisian pomegranate (Punica granatum) fruits. J Food Sci 76(5):C70713. https://doi.org/10.1111/j.1750-3841.2011.02179.x

Article  CAS  Google Scholar 

Erel O (2004) A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 37(4):277–285. https://doi.org/10.1016/j.clinbiochem.2003.11.015

Article  CAS  PubMed  Google Scholar 

Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38(12):1103–1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008

Article  CAS  PubMed  Google Scholar 

Eşrefoğlu M, Gül M, Ates B, Batçioğlu K, Selimoğlu MA (2006a) a) Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. World J Gastroenterol 12(2):259–264. https://doi.org/10.3748/wjg.v12.i2.259

Article  PubMed  PubMed Central  Google Scholar 

Eşrefoğlu M, Gül M, Ateş B, Selimoğlu MA (2006b) b) Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis. J Pineal Res 40(1):92–97. https://doi.org/10.1111/j.1600-079X.2005.00288.x

Article  CAS  PubMed  Google Scholar 

Eşrefoğlu M, Gül M, Turan F (2008) Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis. Dig Dis Sci 53(5):1303–1310

Article  PubMed  Google Scholar 

Esrefoglu M (2009) Cell injury and death: oxidative stress and antioxidant defense system. Turkiye Klinikleri Journal of Medical Sciences 29(6):1660–1676

Google Scholar 

Fischer UA, Carle R, Kammerer DR (2011) Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MS(n). Food Chem 127(2):807–821. https://doi.org/10.1016/j.foodchem.2010.12.156

Gorelick FS, Lerch MM (2017) Do animal models of acute pancreatitis reproduce human disease? Cell Mol. Gastroenterol Hepatol 4:251–262. https://doi.org/10.1016/j.jcmgh.2017.05.007

Article  Google Scholar 

Gupta P, Choudhury S, Ghosh S, Mukherjee S, Chowdhury O, Sain A, Chattopadhyay S (2019) Dietary pomegranate supplement alleviates murine pancreatitis by modulating Nrf2-p21 interaction and controlling apoptosis to survival switch. J Nutr Biochem 66:17–28. https://doi.org/10.1016/j.jnutbio.2018.12.009

Article  CAS  PubMed  Google Scholar 

Gukovskaya AS, Perkins PE, Zaninovic VJ, Sandoval D, Rutherfort R et al (1996) Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 110:875–884

Article  CAS  PubMed  Google Scholar 

Hammer HF (2014) An update on pancreatic pathophysiology (do we have to rewrite pancreatic pathophysiology?). Wien Med Wochenschr 164(3–4):57–62

Article  PubMed  Google Scholar 

Harde H, Schumacher W, Firbas F, Deffer D (1970) Strasburg’s textbook of botany. Chaucer, London, p 2

Google Scholar 

Jankowski A, Jankowska B, Niedworok J (2000) The influence of Aronia melanocapra in experimental pancreatitis. Pol Merkur Lekarski 8(48):395–398

CAS  PubMed  Google Scholar 

Jurendic T, Scetar M (2021) Aronia melanocarpa Products and By-Products for Health and Nutrition: A Review. Antioxidants (Basel) 10(7):1052. https://doi.org/10.3390/antiox10071052

Article  CAS  PubMed  Google Scholar 

Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Sigman CC (1994) Chemopreventive drug development: perspectives and progress. Cancer Epidemiol Biomarkers Prev 3(1):85–98

CAS  PubMed  Google Scholar 

Koiwai T, Oguchi H, Kawa S, Yanagisawa Y, Kobayashi T, Homma T (1989) The role of oxygen free radicals in experimental acute pancreatitis in the rat. Int J Pancreatol 5(2):135–143

Article  CAS  PubMed  Google Scholar 

Kryzhevskii VV, Nichitailo ME, Medvetskii MG (2000) The role of cytokines in pathogenesis of acute pancreatitis. Klin Khir 1:54–57

Google Scholar 

Kubisch CH, Sans MD, Arumugam T, Ernst SA, Williams JA, Logsdon CD (2006) Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 291:G238-245. https://doi.org/10.1152/ajpgi.00471.2005

Article  CAS  PubMed  Google Scholar 

Kulling SE, Rawel HM (2008) Chokeberry (Aronia melanocarpa) - A review on the characteristic components and potential health effects. Planta Med 74(13):1625–1634

Article  CAS  PubMed  Google Scholar 

Lampel M, Kern H (1977) Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch. A Pathology, Anatomy, and Hisology 373:97–117

CAS  Google Scholar 

Lee SI, Kim BS, Kim KS, Lee S, Shin KS, Lim JS (2008) Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochem Biophys Res Commun 371(4):799–803. https://doi.org/10.1016/j.bbrc.2008.04.150

Article  CAS  PubMed  Google Scholar 

Mahdizadeh S, Khaleghi Ghadiri M, Gorji A (2015) Avicenna’s Canon of Medicine: a review of analgesics and anti-inflammatory substances. Avicenna J Phytomed 5(3):182–202

CAS  PubMed  PubMed Central  Google Scholar 

Melgarejo P, Salazar DM, Artes F (2000) Organic acids and sugars composition of harvested pomegranate fruits. Eur Food Res Technol 211(3):185–190

Article  CAS  Google Scholar 

Minaiyan M, Zolfaghari B, Taheri D, Gomarian M (2014) Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice. Int J Prev Med 5(4):394–404

Mizunuma T, Kawamura S, Kishino Y (1984) Effects of injecting excess arginine on rat pancreas. J Nutr 114:467–471. https://doi.org/10.1093/jn/114.3.467

Article  CAS  PubMed  Google Scholar 

Nonaka A, Manabe T, Kyogoku T, Tamura K, Tobe T (1992) Evidence for a role of free radicals by synthesized scavenger, 2-octadecylascorbic acid, in cerulein-induced mouse acute pancreatitis. Dig Dis Sci 37(2):274–279

Article  CAS  PubMed