Ahmad VU, Yasmeen S, Ali Z, Khan MA, Choudhary MI, Akhtar F et al (2000) Taraxacin, a new guaianolide from taraxacum wallichii. J Nat Prod 63(7):1010–1011
Badloe FMS, De Vriese S, Coolens K, Schmidt-Weber CB, Ring J, Gutermuth J et al (2020) IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis. Clin Transl Allergy 10:34
CAS PubMed PubMed Central Google Scholar
Bernard FX, Morel F, Camus M, Pedretti N, Barrault C, Garnier J et al (2012) Keratinocytes under fire of proinflammatory cytokines: Bona Fide innate immune cells involved in the physiopathology of chronic atopic dermatitis and psoriasis. J Allergy 2012:718725
Boccardi D, D’Auria E, Turati F, M DIV, Sortino S, Riva E et al (2017) Disease severity and quality of life in children with atopic dermatitis: PO-SCORAD in clinical practice. Minerva Pediatr 69(5):373–380
Boguniewicz M, Leung DY (2010) Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 125(1):4–13 quiz 4–5
PubMed PubMed Central Google Scholar
Bu C, Wang R, Wang Y, Lu B, He S, Zhao X (2022) Taraxasterol inhibits hyperactivation of macrophages to alleviate the Sepsis-induced inflammatory response of ARDS rats. Cell Biochem Biophys 80(4):763–770
Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å (2020) Prevalence and incidence of atopic dermatitis: a systematic review. Acta dermato-venereologica 100(12):adv00160
Čepelak I, Dodig S, Pavić I (2019) Filaggrin and atopic March. Biochemia Med 29(2):020501
Che L, Li Y, Song R, Qin C, Hao W, Wang B et al (2019) Anti-inflammatory and anti-apoptosis activity of taraxasterol in ulcerative colitis in vitro and in vivo. Exp Therap Med 18(3):1745–1751
Chen J, Wu W, Zhang M, Chen C (2019a) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice. Int Immunopharmacol 70:274–283
Chen W, Da W, Li C, Fan H, Liang R, Yuan J et al (2019b) Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis. Int Immunopharmacol 71:259–266
Clark RA, Schlapbach C (2017) T(H)9 cells in skin disorders. Semin Immunopathol 39(1):47–54
de Vries IJ, Langeveld-Wildschut EG, van Reijsen FC, Dubois GR, van den Hoek JA, Bihari IC et al (1998) Adhesion molecule expression on skin endothelia in atopic dermatitis: effects of TNF-alpha and IL-4. J Allergy Clin Immunol 102(3):461–468
Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA (2017) The burden of atopic dermatitis: summary of a report for the National eczema association. J Invest Dermatol 137(1):26–30
Han H, Roan F, Ziegler SF (2017) The atopic March: current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol Rev 278(1):116–130
CAS PubMed PubMed Central Google Scholar
Jin W, Huang W, Chen L, Jin M, Wang Q, Gao Z et al (2018) Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-inflammatory responses in DNCB-Induced atopic dermatitis model mice. Int J Mol Sci 19(12)
Kim YJ, Choi MJ, Bak DH, Lee BC, Ko EJ, Ahn GR et al (2018) Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice. Sci Rep 8(1):11895
PubMed PubMed Central Google Scholar
Kim TY, Park NJ, Jegal J, Choi S, Lee SW, Hang J et al (2019) Chamaejasmine isolated from wikstroemia Dolichantha diels suppresses 2,4-Dinitrofluoro-benzene-Induced atopic dermatitis in SKH-1 hairless mice. Biomolecules 9(11)
Kim SH, Seong GS, Choung SY (2020) Fermented Morinda citrifolia (Noni) alleviates DNCB-Induced atopic dermatitis in NC/Nga mice through modulating immune balance and skin barrier function. Nutrients 12(1)
Lee KS, Chun SY, Lee MG, Kim S, Jang TJ, Nam KS (2018) The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water. Biomed Pharmacother Biomedecine Pharmacotherapie 97:1331-40
Li C, Zheng Z, Xie Y, Zhu N, Bao J, Yu Q et al (2020) Protective effect of taraxasterol on ischemia/reperfusion-induced acute kidney injury via Inhibition of oxidative stress, inflammation, and apoptosis. Int Immunopharmacol. 89(Pt A):107169
Liu J, Xiong H, Cheng Y, Cui C, Zhang X, Xu L et al (2013) Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. J Ethnopharmacol 148(3):787–793
Liu B, He Z, Wang J, Xin Z, Wang J, Li F et al (2018) Taraxasterol inhibits LPS-Induced inflammatory response in BV2 microglia cells by activating LXRα. Front Pharmacol 9:278
PubMed PubMed Central Google Scholar
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods 25(4):402–408
Mittermann I, Wikberg G, Johansson C, Lupinek C, Lundeberg L, Crameri R et al (2016) IgE sensitization profiles differ between adult patients with severe and moderate atopic dermatitis. PLoS ONE 11(5):e0156077
PubMed PubMed Central Google Scholar
Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H et al (2007) Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 120(1):48–55
Piao T, Ma Z, Li X, Liu J (2015) Taraxasterol inhibits IL-1β-induced inflammatory response in human Osteoarthritic chondrocytes. Eur J Pharmacol 756:38–42
Purushothaman B, Arumugam P, Song JM (2018) A novel Catecholopyrimidine based small molecule PDE4B inhibitor suppresses inflammatory cytokines in atopic mice. Front Pharmacol 9:485
PubMed PubMed Central Google Scholar
San Z, Fu Y, Li W, Zhou E, Li Y, Song X et al (2014) Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol 19(2):342–350
Sang R, Yu Y, Ge B, Xu L, Wang Z, Zhang X (2019) Taraxasterol from taraxacum prevents Concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif Cells Nanomed Biotechnol 47(1):3929–3937
Shiohara T, Hayakawa J, Mizukawa Y (2004) Animal models for atopic dermatitis: are they relevant to human disease? J Dermatol Sci 36(1):1–9
Simpson EL (2010) Atopic dermatitis: a review of topical treatment options. Curr Med Res Opin 26(3):633–640
Wahn U, Bos JD, Goodfield M, Caputo R, Papp K, Manjra A et al (2002) Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. Pediatrics 110(1 Pt 1):e2
Wang S, Wang Y, Liu X, Guan L, Yu L, Zhang X (2016) Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats. J Ethnopharmacol 187:42–48
Weidinger S, Novak N (2016) Atopic dermatitis. Lancet (London England) 387(10023):1109–1122
Xiong X, Huang C, Wang F, Dong J, Zhang D, Jiang J et al (2021) Qingxue Jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways. J Ethnopharmacol 270:113773
Xu L, Yu Y, Sang R, Li J, Ge B, Zhang X (2018) Protective effects of taraxasterol against ethanol-induced liver injury by regulating CYP2E1/Nrf2/HO-1 and NF-κB signaling pathways in mice. Oxid Med Cell Longev 8284107
Yang Y, Li S (2015) Dandelion extracts protect human skin fibroblasts from UVB damage and cellular senescence. Oxidative Med Cell Longev 2015:619560
PubMed PubMed Central Google Scholar
Ye XJ, Xu R, Liu SY, Hu B, Shi ZJ, Shi FL et al (2022) Taraxasterol mitigates Con A-induced hepatitis in mice by suppressing interleukin-2 expression and its signaling in T lymphocytes. Int Immunopharmacol 102:108380
Yu H, Li H, Li Y, Li M, Chen G (2017) Effect of Isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice. Arch Dermatol Res 309(10):805–813
Zeng D, Chen C, Zhou W, Ma X, Pu X, Zeng Y et al (2021) TRPA1 deficiency alleviates inflammation of atopic dermatitis by reducing macrophage infiltration. Life Sci 266:118906
Zhang X, Xiong H, Liu L (2012) Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 141(1):206–211
Zhang Y, Fu H, Zhang Y, Wang D, Zhao D, Zhang J et al (2022) Reparative effects of dandelion fermentation broth on UVB-Induced skin inflammation. Clin Cosmet Invest Dermatol 15:471–482
Zheng F, Dong X, Meng X (2018) Anti-Inflammatory effects of taraxasterol on LPS-Stimulated human umbilical vein endothelial cells. Inflammation 41(5):1755–1761
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