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The Role of Coagulation/Fibrinolysis Biomarkers in Pathophysiology, Disease Severity, and Treatment Response in Patients with Urticaria: A Scoping Review
The Role of Coagulation/Fibrinolysis Biomarkers in Pathophysiology, Disease Severity, and Treatment Response in Patients with Urticaria: A Scoping Review
The pathology of urticaria is complex. Recently, researchers have widely focused on the role that the coagulation/fibrinol...
Th17 Response in Uveitis: A Double-Edged Sword in Ocular Inflammation and Immune Regulation
Th17 Response in Uveitis: A Double-Edged Sword in Ocular Inflammation and Immune Regulation
Uveitis involves a complex interplay of immune cell infiltration and cytokine imbalances, with Th17 cells playing a centra...
The Role of IL-17 in Systemic Autoinflammatory Diseases: Mechanisms and Therapeutic Perspectives
The Role of IL-17 in Systemic Autoinflammatory Diseases: Mechanisms and Therapeutic Perspectives
Interleukin (IL)-17, a pro-inflammatory cytokine, plays a pivotal role in immune regulation by bridging innate and adaptiv...
The Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis
The Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis
Historically, lactate has been considered merely a metabolic byproduct. However, recent studies have revealed that lactate...
The Role of MA Modification in Autoimmunity: Emerging Mechanisms and Therapeutic Implications
The Role of MA Modification in Autoimmunity: Emerging Mechanisms and Therapeutic Implications
N6-methyladenosine (m6A), a prevalent and essential RNA modification, serves a key function in driving autoimmune disease ...
Implication of Immunobiological Function of Melanocytes in Dermatology
Implication of Immunobiological Function of Melanocytes in Dermatology
Melanocytes are essential for regulating pigmentation and providing photoprotection in human skin. Originating from neural...
Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases
Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases
The recurrence of inflammatory skin diseases represents a significant challenge in clinical practice, primarily mediated b...
Emerging Contaminants: An Important But Ignored Risk Factor for Psoriasis
Emerging Contaminants: An Important But Ignored Risk Factor for Psoriasis
Industrialization and modernization have changed the environment. A group of emerging contaminants (ECs) has been defined ...
Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis
Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease involving activation of the immune system and the infiltration ...
The Impact of Mast Cells on the Anatomy, Cellular Communication, and Molecular Immune Network of Lymph Nodes
The Impact of Mast Cells on the Anatomy, Cellular Communication, and Molecular Immune Network of Lymph Nodes
Lymph nodes (LNs) are ovoid-shape capsulated structures interposed along the lymphatic vessels. Owing to their unique arch...
Maternal Immune Activation: Implications for Congenital Heart Defects
Maternal Immune Activation: Implications for Congenital Heart Defects
Congenital heart defects (CHD) are the most common major birth defects and one of the leading causes of death from congeni...
Molecular Allergology: Epitope Discovery and Its Application for Allergen-Specific Immunotherapy of Food Allergy
Molecular Allergology: Epitope Discovery and Its Application for Allergen-Specific Immunotherapy of Food Allergy
The prevalence of food allergy continues to rise, posing a significant burden on health and quality of life. Research on a...
Epigenetic Modifications in Vitiligo
Epigenetic Modifications in Vitiligo
Vitiligo is an autoimmune depigmenting skin disorder and can affect the mental health of the patients. Current research su...
Effectiveness and Safety of Nemolizumab in Patients with Prurigo Nodularis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effectiveness and Safety of Nemolizumab in Patients with Prurigo Nodularis: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Prurigo nodularis (PN) is a chronic, severely pruritic condition that markedly impairs quality of life. Existing treatment...
Targeting B Cells for the Treatment of Idiopathic Inflammatory Myopathy
Targeting B Cells for the Treatment of Idiopathic Inflammatory Myopathy
Idiopathic inflammatory myopathy (IIM) is a group of heterogeneous diseases that can affect multiple systems. Currently, i...
Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis
Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis
Osteoporosis, a common metabolic condition that affects the bones, increases the risk of fractures, thereby diminishing on...
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential
Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by chronic inflammation and multi-organ d...
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis
Inhalant allergen–mediated respiratory diseases, including asthma and allergic rhinitis, have become increasing glob...
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
The role of abnormal epigenetic modifications, particularly DNA methylation, in the pathogenesis of autoimmune rheumatic d...
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Autoimmune diseases (AIDs) are complex in etiology and diverse in classification but clinically show similar symptoms such...
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic dermatitis and psoriasis are common chronic inflammatory diseases of high incidence that share some clinical featur...
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen-based diagnostics are essential in the management algorithm of allergic diseases. Unlike systemic allergy, where ...
Neutrophils in Atopic Dermatitis
Neutrophils in Atopic Dermatitis
Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain typ...
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis
Non-allergic rhinitis (NAR) is a prevalent condition with limited effective treatments. Capsaicin, an agonist of the trans...
Non-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
Non-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
The presence of IgG anti-IgA in the serum of primary immunodeficiency (PID) patients has long been considered responsible ...
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients
Apart from the skin and mucosal immune barrier, the first line of defense of the human immune system includes MDA5 (ifih1 ...
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases
Regulatory T (Treg) cells are crucial for maintaining immune tolerance by suppressing response to self-antigens and harmle...
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Long-term prophylaxis (LTP) has been shown to reduce the frequency of hereditary angioedema (HAE) attacks; however, attack...
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway...
Acute Aseptic Meningitis Temporally Associated with Intravenous Polyclonal Immunoglobulin Therapy: A Systematic Review
Acute Aseptic Meningitis Temporally Associated with Intravenous Polyclonal Immunoglobulin Therapy: A Systematic Review
An acute aseptic meningitis has been occasionally observed on intravenous polyclonal human immunoglobulin therapy. Since c...
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