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Nitrogen-inversion-based racemate aggregation and interenantiomer -stacking-caused solid-state fluorescence enhancement
The solid-state fluorescence of fluorophores is usually weakened or quenched by strong π-π interactions. Here, the solid-s...
Photoinduced Co-catalyzed dehydrogenative cyclization of 2-alkenylphenyl carbonyl compounds and mechanistic insights
In this work, we present a UV-induced 6π-cyclization protocol enabling the synthesis of polysubstituted naphthol skeletons...
Dearomative 2,3-Diamination of Indoles Triggered by Rh(III)-Catalyzed Csp2-H Activation
A Rh(III)-catalyzed dearomative 2,3-diamination of indoles with N-alkoxyamides has been developed. The method provides an ...
An Unexpected Lewis Acid-Catalyzed Cascade Reaction of Bicyclo[1.1.0]butanes with Triazinanes to Biscyclobutenyl Amines
An unexpected In(OTf)3-catalyzed cascade reaction of bicyclo[1.1.0]butanes with triazinanes is reported, providing a serie...
Remodelling Molecular Frameworks via Atom-Level Surgery: Recent Advances in Skeletal Editing of (Hetero)Cycles
Skeletal editing is an emerging approach in synthetic chemistry that enables precise atom-level modifications within molec...
Bridged Rings from Phenolic Feedstocks: Regio- and Diastereoselective Substitution-Hemiketalization Cyclization of Bridged Benzoxocin-4-ones with Grignard Reagents
The efficient and controllable generation of bridged polycycles of structural complexity and diversity from readily avaial...
Access to (Bridged) Bicyclic Ureas through Azocarboxamide-Enabled Enantioselective 1,2-Diamination of α-Branched Cyclic Ketones
Chiral bicyclic ureas are important multi-nitrogen-containing polycyclic frameworks and valuable building blocks in organi...
Palladium-Catalyzed Multicomponent [4+2] Cycloaddtion of 1, 4-Enynes with CO and Arylamines to Access Polycyclic γ-Lactams via Dearomative Rearrangement
Herein we report a novel palladium-catalyzed intermolecular dearomative [4+2] cycloaddition of 1, 4-enynes with CO and ary...
Supramolecular Chiroptical Sensing by Achiral AIE-active Thiols
Rapid and sensitive chiroptical sensing is of great significance for practical applications. Here, a novel rapid supramole...
Synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines through a sequential multicomponent assembly, oxygenation and 6πe electrocyclization reactions
A novel metal-free synthetic method is presented for the 2-arylchromeno[2,3,4,5-lmna]phenanthridines from the one-pot reac...
Giese Reaction of Alkyl Bromides using Amine Carboxyboranes
Amine carboxyborane enabled an efficient halogen atom transfer (XAT) with 1o, 2o, and 3o alkyl bromides, resulting in Gies...
Computational Study on Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarene: Mechanisms and the Role of Base
Density functional theory (DFT) calculations were performed to study Pd-catalyzed ipso,meta-dimethylation reaction of orth...
Progress in Catalytic Enantioselective Construction of Difluoroalkylated Stereogenic Center
Molecules bearing the difluoroalkyl groups were very important in pharmaceuticals, argrochemicals and materials. In recent...
Synthesis of a cross-chain bridging cryptand
We present two methodologies for synthesizing cross–chain bridging cryptand 1 that incorporates tri- and tetra(ethylene gl...
A domino reaction strategy for facile and modular construction of synthetically challenging functionalized ortho-fluoroanilines
The selective formation of ortho-fluoroanilines, representing versatile intermediates for the pharmaceutical and fine chem...
Asymmetric construction of spirobenzofuran indolinones via cascade reaction of 3-hydroxyoxindoles with coumarins
An interesting asymmetric organocatalytic cascade reaction of 3-hydroxyoxindoles with coumarins was accomplished by chiral...
Asymmetric Synthesis of Pyrrolo[1,2-a]indoles via Bifunctional Tertiary Amine Catalyzed [3+2] Annulation of 2-Nitrovinylindoles with Azlactones
The chiral pyrrolo[1,2-a]indole represents a privileged stuctural motif in many natual products and pharmaceutical agents....
Hypervalent Iodide(III)-Mediated Thiofluorination of Alkenes and Alkynes from Thioureas/Thiocarbamoyl Fluorides with Water and Nucleophilic Fluoride Source
Hypervalent iodines(III) mediated oxo/aza/carbon/difluorination of alkenes have made significant progress although the cor...
Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates
This paper aims to explore the applications of modified cysteine in biomedicine, addressing the challenges as-sociated wit...
Ion-pairing assemblies of anion-responsive helical PtII complexes
Naphthylisoquinoline-appended dipyrrolyldiketone PtII complexes as helical π-electronic systems were synthesized. The PtII...
Shining light on sulfonium salts and sulfur ylides: recent advances in alkylation under photoredox catalysis
Organosulfur compounds, especially sulfur ylides and sulfonium salts, offer extraordinary potential in organic chemistry d...
Exploring N-Centered Umpolung Reactivity in Photoredox-Catalyzed Amidation with α-Iminoester
The synthesis of amides and their derivatives has gained significant attention among the scientific community in recent de...
Mechanistic Insights into the Gold(I)-Catalyzed [3,3]-Sigmatropic Rearrangement of Sulfoniums for the Formation of Chiral 1,4-Dicarbonyls or Formal α-Arylation of Carbonyl Compounds
Starting with vinyl sulfoxides and propargyl silane, the Au(I)-catalyzed asymmetric [3,3]-sigmatropic rearrangement of sul...
Recent Developments in the Ring-Opening Transformations of gem-Difluorocyclopropanes
gem-Difluorocyclopropanes (F2CPs), a unique class of cyclopropanes, have attracted particular interest of chemists due to ...
Deoxygenative 1,3-Carbophosphination of Allylic Alcohols enabled by Manganese Pincer Catalyst
Organophosphines are versatile compounds with widespread applications in both organic synthesis and the development of bio...
Electrochemical 1,2-hydrogen atom transfer functionalizations of N-(benzyloxy)phthalimides
We report a straightforward, catalyst-free method for the cathodic benzylic C–H hydroxyalkylation/arylation of N-(alkyloxy...
Ir/XuPhos-Catalyzed Direct Asymmetric Reductive Amination of Ketones with Secondary Amines
A diverse array of bidentate P-containing ligands has been developed for Ir-catalyzed asymmetric hydrogenation, but chiral...
Hydrogen autotransfer with alcohols for alkylations
Despite the advancements enabled by organometallic complexes in organic synthesis, which have led to innovative transforma...
Zn/F Carbenoids: Preparation, Structures, Stability, and Application to Nucleophilic Monofluoroalkylation
Carbenoids have been important reactive intermediates in organic synthesis. Thus, numerous investigations have focused on ...
Selective C2 and C3 Phosphorylmethylation of Indoles with a Phosphorylmethyl Dibenzothiophenium Reagent
A novel electrophilic phosphorylmethylating reagent, S-([diethoxyphosphoryl]methyl) dibenzothiophenium salt, has been succ...
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