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Biomarkers of long-term consequences of traumatic brain injuries sustained during military service
Biomarkers of long-term consequences of traumatic brain injuries sustained during military service
Traumatic brain injuries (TBIs) have been a common consequence of combat since prehistoric times, and injuries to the cran...
Ischaemic stroke in the young--is it time to consider alcohol reduction for stroke prevention?
Ischaemic stroke in the young--is it time to consider alcohol reduction for stroke prevention?
While red wine has been touted to reduce myocardial infarction, the association between alcohol and cardiovascular disease...
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
WHAT IS ALREADY KNOWN ON THIS TOPICMilitary neurotrauma has been associated with increased dementia risk, but a detailed u...
Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case-control study
Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case-control study
IntroductionLarge studies from the last decade have demonstrated a high prevalence of traditional risk factors in young pa...
Measurement properties of the Inclusion Body Myositis Functional Rating Scale
Measurement properties of the Inclusion Body Myositis Functional Rating Scale
AbstractObjectives To evaluate the validity, reliability, responsiveness and meaningful change threshold of the Inclusion ...
Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy
Linking LRP12 CGG repeat expansion to inherited peripheral neuropathy
IntroductionInherited peripheral neuropathy (IPN) constitutes a heterogeneous spectrum of hereditary neurological disorder...
Identification of a pathogenic mutation in ARPP21 in patients with amyotrophic lateral sclerosis
Identification of a pathogenic mutation in ARPP21 in patients with amyotrophic lateral sclerosis
IntroductionAmyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease, characterised by muscle weakness an...
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis
IntroductionMultiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous...
Distinct plasma lipids predict axonal injury and multiple sclerosis activity
Distinct plasma lipids predict axonal injury and multiple sclerosis activity
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Functional pathology of neuroleptic-induced dystonia based on the striatal striosome-matrix dopamine system in humans
Functional pathology of neuroleptic-induced dystonia based on the striatal striosome-matrix dopamine system in humans
AbstractNeuroleptic-induced dystonia is a source of great concern in clinical practice because of its iatrogenic nature wh...
Vitamin D affects the risk of disease activity in multiple sclerosis
Vitamin D affects the risk of disease activity in multiple sclerosis
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Directional deep brain stimulation electrodes in Parkinsons disease: meta-analysis and systematic review of the literature
Directional deep brain stimulation electrodes in Parkinsons disease: meta-analysis and systematic review of the literature
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Socioeconomic burden of AQP4-antibody seropositive NMOSD: a nationwide registry-based study
Socioeconomic burden of AQP4-antibody seropositive NMOSD: a nationwide registry-based study
IntroductionAQP4-antibody seropositive neuromyelitis optica spectrum disorder (AQP4-Ab+NMOSD) is a severe, chronic, relaps...
Novel observation for adult ataxia-telangiectasia: evaluating the lack of hypointensity of the dentate nuclei
Novel observation for adult ataxia-telangiectasia: evaluating the lack of hypointensity of the dentate nuclei
Ataxia-telangiectasia (A-T) remains an incurable disease with limited treatment options. The progression of clinical trial...
Spinal cord motor neuron phenotypes and polygenic risk scores in sporadic amyotrophic lateral sclerosis: deciphering the disease pathology and therapeutic potential of ropinirole hydrochloride
Spinal cord motor neuron phenotypes and polygenic risk scores in sporadic amyotrophic lateral sclerosis: deciphering the disease pathology and therapeutic potential of ropinirole hydrochloride
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by both upper and lower motor...
Highlighting the past and future of inherited peripheral neuropathies
Highlighting the past and future of inherited peripheral neuropathies
Inherited peripheral neuropathies (IPN) are among the most common inherited conditions in Neurology and are still largely ...
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
IntroductionInherited peripheral neuropathies (IPNs) are a group of inherited diseases affecting the peripheral nervous sy...
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
IntroductionThe pathogenesis of multiple sclerosis (MS) requires both environmental events and genetic factors.1–4 Conside...
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
IntroductionSelf-reported fatigue, a prevalent and debilitating symptom affecting up to two-thirds of people with multiple...
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
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A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
WHAT IS ALREADY KNOWN ON THIS TOPICThere is emerging evidence that suggests accelerated intermittent theta burst stimulati...
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
IntroductionThe challenge of monitoring changing patterns of disease at population levels1 arises from variations in healt...
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
WHAT IS ALREADY KNOWN ON THIS TOPICMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) patients may ex...
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
WHAT IS ALREADY KNOWN ON THIS TOPICPlasma pTau217 is the most promising biomarker for cerebral amyloidosis and Alzheimer’s...
Exercise as medicine in Parkinsons disease
Exercise as medicine in Parkinsons disease
IntroductionParkinson’s disease (PD) is a chronic debilitating disorder of the central nervous system. It is the fastest g...
Identification of DAGLA as an autoantibody target in cerebellar ataxia
Identification of DAGLA as an autoantibody target in cerebellar ataxia
IntroductionCerebellar ataxia can be caused by different aetiologies including genetic, infectious or neurodegenerative di...
Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study
Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study
IntroductionGNE myopathy is a hereditary muscle disorder characterised by a gradually progressive decrease in muscle stren...
Nigrostriatal blood-brain barrier opening in Parkinsons disease
Nigrostriatal blood-brain barrier opening in Parkinsons disease
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Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
The era of modern medicine is often linked to the first clinical application of penicillin in 1943.1 How far we have come ...
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
In their JNNP meta-analysis Pozzilli et al concludes that sphingosine-1-phosphate receptor (S1PR) modulators substantially...
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