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Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes
Proteins traverse the eukaryotic secretory pathway through membrane trafficking between organelles. The coat protein compl...
Structural basis of the mechanism and inhibition of a human ceramide synthase
Structural basis of the mechanism and inhibition of a human ceramide synthase
Ceramides are bioactive sphingolipids crucial for regulating cellular metabolism. Ceramides and dihydroceramides are synth...
Structure of the yeast ceramide synthase
Structure of the yeast ceramide synthase
Ceramides are essential lipids involved in forming complex sphingolipids and acting as signaling molecules. They result fr...
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair
The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as w...
Menopause age and cancer risk is influenced by rare genetic variants
Menopause age and cancer risk is influenced by rare genetic variants
Using data from the UK Biobank the researchers analyzed the rare variants in the protein coding region in the genomes of 1...
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase
The heart, in addition to its primary role in blood circulation, functions as an endocrine organ by producing cardiac horm...
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections, particularly endocarditis and s...
Structural insights into SV2A and the mechanism of racetam anticonvulsants
Structural insights into SV2A and the mechanism of racetam anticonvulsants
Racetam anticonvulsants, such as levetiracetam, are widely prescribed to treat and prevent seizures. Despite decades of cl...
How protons shape AMPA receptor structure, function and diffusion at the synapse
How protons shape AMPA receptor structure, function and diffusion at the synapse
The extracellular AMPA receptor N-terminal domain (NTD) affects synaptic strength by tuning receptor diffusion. We reveal ...
Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression
Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression
DNA supercoiling is a biophysical feature of the double helix with a pivotal role in biological processes. However, unders...
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication
Three-dimensional (3D) genome folding has a fundamental role in the regulation of developmental genes by facilitating or c...
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies
Eukaryotic members of the endosome sorting complex required for transport-III (ESCRT-III) family have been shown to form d...
Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA
Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA
Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), ...
Putting together pieces of the LIN28A pathway puzzle
Putting together pieces of the LIN28A pathway puzzle
Two recent studies provide mechanistic insights into how LIN28A controls changes in cell fate identity, focusing on either...
Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level
Dynamics of an epigenetic regulator on chromatin observed at the single-molecule level
Methyl-CpG-binding protein 2 (MeCP2) is a master regulator of neuronal gene expression, and its genetic mutations cause th...
Structural basis for lipid transfer by the ATG2A–ATG9A complex
Structural basis for lipid transfer by the ATG2A–ATG9A complex
Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes. Autophagy-related proteins ...
Vimentin filaments integrate low-complexity domains in a complex helical structure
Vimentin filaments integrate low-complexity domains in a complex helical structure
Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanic...
DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to...
Macrophages need to release the proximal brake to degrade cellular corpses
Macrophages need to release the proximal brake to degrade cellular corpses
Writing in Nature, T. Tufan et al.1 address this gap in knowledge and provide novel functional and mechanistic insight int...
Membrane-embedded machines
The first membrane protein structure was reported almost 40 years ago. In this issue, we are publishing a set of papers th...
Future opportunities in solute carrier structural biology
Future opportunities in solute carrier structural biology
Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, t...
Transcription directionality is licensed by Integrator at active human promoters
Transcription directionality is licensed by Integrator at active human promoters
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce...
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Protein SUMOylation provides a principal driving force for cellular stress responses, including DNA–protein crosslin...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
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