Clark, A. G. & Vignjevic, D. M. Modes of cancer cell invasion and the role of the microenvironment. Curr. Opin. Cell Biol. 36, 13–22 (2015).
Article CAS PubMed Google Scholar
Krause, M. & Gautreau, A. Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nat. Rev. Mol. Cell Biol. 15, 577–590 (2014).
Article CAS PubMed Google Scholar
Goley, E. D. & Welch, M. D. The Arp2/3 complex: an actin nucleator comes of age. Nat. Rev. Mol. Cell Biol. 7, 713–726 (2006).
Article CAS PubMed Google Scholar
Swaney, K. F. & Li, R. Function and regulation of the Arp2/3 complex during cell migration in diverse environments. Curr. Opin. Cell Biol. 42, 63–72 (2016).
Article CAS PubMed PubMed Central Google Scholar
Gournier, H., Goley, E. D., Niederstrasser, H., Trinh, T. & Welch, M. D. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol. Cell 8, 1041–1052 (2001).
Article CAS PubMed Google Scholar
Robinson, R. C. et al. Crystal structure of Arp2/3 complex. Science 294, 1679–1684 (2001).
Article CAS PubMed Google Scholar
Goley, E. D. et al. An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. Proc. Natl Acad. Sci. USA 107, 8159–8164 (2010).
Article CAS PubMed PubMed Central Google Scholar
Rotty, J. D., Wu, C. Y. & Bear, J. E. New insights into the regulation and cellular functions of the Arp2/3 complex. Nat. Rev. Mol. Cell Biol. 14, 7–12 (2013).
Article CAS PubMed Google Scholar
Dang, I. et al. Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature 503, 281–284 (2013).
Article CAS PubMed Google Scholar
Rocca, D. L., Martin, S., Jenkins, E. L. & Hanley, J. G. Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Nat. Cell Biol. 10, 259–271 (2008).
Article CAS PubMed PubMed Central Google Scholar
Zuo, X. F. et al. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat. Cell Biol. 8, 1383–1388 (2006).
Article CAS PubMed Google Scholar
Schnoor, M., Stradal, T. E. & Rottner, K. Cortactin: cell functions of a multifaceted actin-binding protein. Trends Cell Biol. 28, 79–98 (2018).
Article CAS PubMed Google Scholar
Cai, L., Makhov, A. M., Schafer, D. A. & Bear, J. E. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cell 134, 828–842 (2008).
Article CAS PubMed PubMed Central Google Scholar
Zhao, K. L. et al. WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis. EMBO Rep. 21, e49269 (2020).
Article CAS PubMed PubMed Central Google Scholar
Zheng, S. H. et al. Role and mechanism of actin-related protein 2/3 complex signaling in cancer invasion and metastasis: a review. Medicine 102, e33158 (2023).
Article CAS PubMed Google Scholar
Molinie, N. & Gautreau, A. The Arp2/3 regulatory system and its deregulation in cancer. Physiol. Rev. 98, 215–238 (2018).
Article CAS PubMed Google Scholar
Keenan, K. E., Zachman, D. K. & Hirschey, M. D. Discovering the landscape of protein modifications. Mol. Cell 81, 1868–1878 (2021).
Article CAS PubMed PubMed Central Google Scholar
Dikic, I. & Schulman, B. A. An expanded lexicon for the ubiquitin code. Nat. Rev. Mol. Cell Biol. 24, 273–287 (2023).
Article CAS PubMed Google Scholar
Komatsu, M. et al. A novel protein-conjugating system for UFM1, a ubiquitin-fold modifier. EMBO J. 23, 1977–1986 (2004).
Article CAS PubMed PubMed Central Google Scholar
Kang, S. H. et al. Two novel ubiquitin-fold modifier 1 (UFM1)-specific proteases, UFSP1 and UFSP2. J. Biol. Chem. 282, 5256–5262 (2007).
Article CAS PubMed Google Scholar
Millrine, D. et al. Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation. Cell Rep. 40, 111168 (2022).
Article CAS PubMed PubMed Central Google Scholar
Tatsumi, K. et al. A novel type of E3 ligase for the UFM1 conjugation system. J. Biol. Chem. 285, 5417–5427 (2010).
Article CAS PubMed Google Scholar
Zhou, X. C. et al. UFMylation: a ubiquitin-like modification. Trends Biochem. Sci. 49, 52–67 (2024).
Article CAS PubMed Google Scholar
Peter, J. J. et al. A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation. EMBO J. 41, e111015 (2022).
Article CAS PubMed PubMed Central Google Scholar
Tatsumi, K. et al. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat. Commun. 2, 181 (2011).
Ishimura, R. et al. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat. Commun. 13, 7857 (2022).
Article CAS PubMed PubMed Central Google Scholar
Qin, B. et al. UFL1 promotes histone H4 ufmylation and ATM activation. Nat. Commun. 10, 1242 (2019).
Article PubMed PubMed Central Google Scholar
Wang, Z. F. et al. MRE11 UFMylation promotes ATM activation. Nucleic Acids Res. 47, 4124–4135 (2019).
Article CAS PubMed PubMed Central Google Scholar
Wang, L. H. et al. UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis. Cell Res. 30, 5–20 (2020).
Article CAS PubMed Google Scholar
Walczak, C. P. et al. Ribosomal protein RPL26 is the principal target of UFMylation. Proc. Natl Acad. Sci. USA 116, 1299–1308 (2019).
Article CAS PubMed PubMed Central Google Scholar
Liang, J. R. et al. A genome-wide ER-phagy screen highlights key roles of mitochondria! metabolism and ER-resident UFMylation. Cell 180, 1160–1177 (2020).
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