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Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system
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Engineering novel adeno-associated viruses (AAVs) for improved delivery in the nervous system
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Beyond chloroquine: Cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics
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Microbial metabolite-receptor interactions in the gut microbiome
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Therapeutic synthetic anion transporters
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Drug discovery targeting Nav1.8: Structural insights and therapeutic potential
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Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling
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Synthetic transporters for oxoanions
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Transferring enzyme features to molecular CO2 reduction catalysts
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Catalyzing the future: recent advances in chemical synthesis using enzymes
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Recent advances in the expanding genetic code
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Corrigendum to “Compounds for selective translational inhibition” [Curr Opin Chem Biol 69 (2022) 102158]
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Synthetic ion channels in biomembranes
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Engineered metallobiocatalysts for energy–relevant reactions
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Corrigendum to “Drug discovery targeting Nav1.8: Structural insights and therapeutic potential” [Curr Opin Chem Biol 83 (2024) 102538]
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Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
In the rhizosphere, plants and microbes communicate chemically, especially under environmental stress. Over millions of ye...
Versatile roles of cysteine persulfides in tumor biology
Versatile roles of cysteine persulfides in tumor biology
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in ...
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
The dynamic equilibrium between the generation of reactive oxygen species (ROS) and the antioxidative defense mechanisms w...
A new era of cysteine proteomics – Technological advances in thiol biology
A new era of cysteine proteomics – Technological advances in thiol biology
Protein cysteines garner interest for their distinct chemical properties, rendering them amenable to a diverse range of mo...
Biochemistry of the hypoxia-inducible factor hydroxylases
Biochemistry of the hypoxia-inducible factor hydroxylases
KeywordsHypoxia-inducible factor (HIF)HIF prolyl-hydroxylases (PHDs/EGLNs)JmjC demethylasesFactor inhibiting HIF (FIH)Aspa...
Lumos maxima – How robust fluorophores resist photobleaching?
Lumos maxima – How robust fluorophores resist photobleaching?
Advanced fluorescence imaging technology, jointly enabled by microscopes and cutting-edge fluorescent labels, promises to ...
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Functional imaging of enzyme activity in living systems provides valuable insights into biological processes and disease s...
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Protein glycosylation, as one of the most widespread and complex post-translational modifications (PTMs), plays an importa...
Site-specific protein labeling strategies for super-resolution microscopy
Site-specific protein labeling strategies for super-resolution microscopy
KeywordsSite-specific labelingSuper-resolution microscopyPeptide-tagPeptide-PAINTUnnatural amino acidNon-canonical amino a...
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Many modern pursuits of molecular biology and biochemistry are built on precise and selective protein labeling techniques....
Fluorogenic polymethine dyes by intramolecular cyclization
Fluorogenic polymethine dyes by intramolecular cyclization
KeywordsFluorogenicityCarbocyaninesPolymethine dyesTurn-on probesIntramolecular cyclizationsSelf-labeling protein tagsSmal...
Chemical toolbox to interrogate Heparanase-1 activity
Chemical toolbox to interrogate Heparanase-1 activity
Heparanase-1 (HPSE-1), an endo-β-d-glucuronidase, is the only known enzyme that cleaves heparan sulfate (HS) [1,2]. The HP...
Chemical biology tools to probe bacterial glycans
Chemical biology tools to probe bacterial glycans
Bacterial cells are covered by a complex carbohydrate coat of armor that allows bacteria to thrive in a range of environme...
Advances in understanding and exploiting Siglec–glycan interactions
Advances in understanding and exploiting Siglec–glycan interactions
Siglecssialic-acid-binding immunoglobulin-type lectinsSAMPself-associated molecular patternITIMimmunoreceptor-tyrosine-bas...
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Heparan sulfate (HS) is an important class of polysaccharides that plays roles in a wide range of biological events, inclu...
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