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CAA proteomics meta-analysis reveals novel targets, key players, and the effects of sex, APOE, and brain region in humans
CAA proteomics meta-analysis reveals novel targets, key players, and the effects of sex, APOE, and brain region in humans
Cerebral amyloid angiopathy (CAA) is a vascular pathology characterized by beta-amylo...
Spatial mapping of the AA-PGE-EP axis in multiple sclerosis lesions
Spatial mapping of the AA-PGE-EP axis in multiple sclerosis lesions
Bioactive lipid mediators (LMs) derived from polyunsaturated fatty acids (PUFAs) are key molecules in both the initiation ...
Widespread distribution of α-synuclein oligomers in -related Parkinson’s disease
Widespread distribution of α-synuclein oligomers in -related Parkinson’s disease
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s dis...
Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases
Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases
Lewy body diseases are common neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy ...
DNA methylation identifies body segment origins of spinal ependymomas
DNA methylation identifies body segment origins of spinal ependymomas
Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655,...
The interactome of tau phosphorylated at T217 in Alzheimer’s disease human brain tissue
The interactome of tau phosphorylated at T217 in Alzheimer’s disease human brain tissue
Hyperphosphorylated tau (pTau) in Alzheimer’s disease (AD) brain tissue is a complex mix of multiple tau species tha...
Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s disease
Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s disease
Oligodendroglia are the responsible cells for myelination in the central nervous system and their involvement in Parkinson...
Multiplatform molecular analyses reveal two molecular subgroups of -related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities
Multiplatform molecular analyses reveal two molecular subgroups of -related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities
NF2-related schwannomatosis (NF2-SWN) is a genetic predisposition syndrome characterized by the development of bilateral v...
Fyn-dependent Tau microcluster formation seeds and boosts extensive Tau pathology
Fyn-dependent Tau microcluster formation seeds and boosts extensive Tau pathology
Tau seeding and propagation are defining features of all tauopathies, including Alzheimer’s disease, but the underly...
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease
Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer’...
Sequence and trajectory of early Alzheimer’s disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits
Sequence and trajectory of early Alzheimer’s disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits
Sporadic Alzheimer’s disease (AD) involves specific neuronal types and progresses in a systematic manner, permitting...
Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer’s disease model mice
Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer’s disease model mice
In Alzheimer’s disease, accumulation of amyloid-β (Aβ) peptide is thought to cause formation of neurofibri...
Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia
Thalamic atrophy in multiple sclerosis is associated with tract disconnection and altered microglia
Thalamic atrophy already occurs in the early stages of multiple sclerosis (MS) and continues progressively throughout the ...
Delineating the mechanisms of cerebellar degeneration in paediatric and adult primary mitochondrial disease
Delineating the mechanisms of cerebellar degeneration in paediatric and adult primary mitochondrial disease
Cerebellar ataxia is a frequent, debilitating neurological manifestation of primary mitochondrial disease and is associate...
SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model
SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model
Individuals with Down Syndrome (DS) represent one of the most susceptible populations for developing severe COVID-19, and ...
Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Alzheimer disease (AD) is the most common form of dementia affecting more than 6 million people in the United States. Curr...
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement f...
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Progressive supranuclear palsy (PSP) is mainly a sporadic disease. It has a multifactorial etiology and an interaction bet...
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Growing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheime...
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 1...
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Astrocytomas that harbor recurrent genomic alterations in MYB or MYBL1 are a group of Pediatric-type diffuse low-grade gli...
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid bet...
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation...
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
The profile of autoantibodies is dysregulated in patients with Alzheimer’s disease (AD). Autoantibodies to beta-site...
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
microRNAs (miRNAs) have a broad influence on gene expression; however, we have limited insights into their contribution to...
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Synaptic dysfunction and loss are central to neurodegenerative diseases and correlate with cognitive decline. Synaptic Ves...
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependy...
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Mesial temporal lobe epilepsy (mTLE) is a debilitating disease characterized by recurrent seizures originating from tempor...
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
Authors and AffiliationsDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 S...
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of n...
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